Duloxetine
- Generic Name
- Duloxetine
- Brand Names
- Cymbalta, Drizalma, Irenka, Yentreve, Duloxetine Zentiva, Duloxetine Mylan, Duloxetine Lilly
- Drug Type
- Small Molecule
- Chemical Formula
- C18H19NOS
- CAS Number
- 116539-59-4
- Unique Ingredient Identifier
- O5TNM5N07U
- Background
Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor. It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval for a variety of indications including the tre...
- Indication
Indicated for:
1) Management of Major Depressive Disorder.
2) Management of Generalized Anxiety Disorder.
3) Management of diabetic peripheral neuropathy.
4) Management of fibromyalgia.
5) Management of chronic musculoskeletal pain.
6) Management of osteoarthritis of the knee in adults.
7) Management of chronic lower back pain in adults.
...
- Associated Conditions
- Chronic Lower Back Pain (CLBP), Chronic Musculoskeletal Pain, Diabetic Peripheral Neuropathic Pain (DPN), Fibromyalgia, Generalized Anxiety Disorder, Major Depressive Disorder (MDD), Osteoarthritis of the Knee, Stress Urinary Incontinence (SUI)
- Associated Therapies
- -
Study of Brain Response to Emotional Pictures Using a fMRI While on Duloxetine
- First Posted Date
- 2007-09-20
- Last Posted Date
- 2016-10-03
- Lead Sponsor
- Indiana University School of Medicine
- Target Recruit Count
- 10
- Registration Number
- NCT00532480
- Locations
- 🇺🇸
Indiana University Adult Psychiatric Clinic, Indianapolis, Indiana, United States
An Open Trial of Duloxetine on Comorbid Major Depression and Chronic Headache
- Conditions
- First Posted Date
- 2007-09-19
- Last Posted Date
- 2007-09-19
- Lead Sponsor
- Kraepelin Psiquiatria Clinica
- Target Recruit Count
- 30
- Registration Number
- NCT00531895
- Locations
- 🇧🇷
Hospital SOCOR, Belo Horizonte, MG, Brazil
Open-Label Study of Duloxetine in the Treatment of Children and Adolescents With Major Depressive Disorder
- First Posted Date
- 2007-09-14
- Last Posted Date
- 2011-10-24
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 72
- Registration Number
- NCT00529789
- Locations
- 🇺🇸
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Bellevue, Washington, United States
Duloxetine for Perimenopausal Depression
- Conditions
- First Posted Date
- 2007-08-17
- Last Posted Date
- 2012-07-09
- Lead Sponsor
- University of Arizona
- Target Recruit Count
- 7
- Registration Number
- NCT00517985
- Locations
- 🇺🇸
Women's Mental Health Program; University of Arizona; Department of Psychiatry, Tucson, Arizona, United States
Safety and Efficacy Study in Subjects With Diabetic Neuropathic Pain
- Conditions
- Interventions
- First Posted Date
- 2007-07-27
- Last Posted Date
- 2013-01-23
- Lead Sponsor
- AbbVie (prior sponsor, Abbott)
- Target Recruit Count
- 280
- Registration Number
- NCT00507936
- Locations
- 🇺🇸
Site Reference ID/Investigator# 6052, Anaheim, California, United States
🇺🇸Site Reference ID/Investigator# 5276, Clearwater, Florida, United States
🇵🇷Site Reference ID/Investigator# 8121, San Juan, Puerto Rico
Duloxetine Versus Duloxetine Plus Non-Drug Therapy for Depression
- Conditions
- First Posted Date
- 2007-06-29
- Last Posted Date
- 2007-07-02
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 940
- Registration Number
- NCT00494377
- Locations
- 🇦🇹
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Wien, Austria
Duloxetine Versus Placebo for Fibromyalgia
- Conditions
- First Posted Date
- 2007-06-21
- Last Posted Date
- 2007-06-21
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 345
- Registration Number
- NCT00489073
- Locations
- 🇺🇸
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Indianapolis, Indiana, United States
Duloxetine Versus Paroxetine for Major Depression
- Conditions
- First Posted Date
- 2007-06-21
- Last Posted Date
- 2007-06-21
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 480
- Registration Number
- NCT00489775
- Locations
- 🇨🇳
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Beijing, China
Urge Incontinence Bladder Overactivity Study
- Conditions
- First Posted Date
- 2007-05-21
- Last Posted Date
- 2007-05-21
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 300
- Registration Number
- NCT00475696
- Locations
- 🇨🇦
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., North York, Ontario, Canada
Efficacy and Safety Stress Urinary Incontinence Study
- Conditions
- First Posted Date
- 2007-05-21
- Last Posted Date
- 2007-05-21
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 120
- Registration Number
- NCT00475358
- Locations
- 🇨🇳
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Tao-Yuan, Taiwan
Drug Development Updates
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