Duloxetine
- Generic Name
- Duloxetine
- Brand Names
- Cymbalta, Drizalma, Irenka, Yentreve, Duloxetine Zentiva, Duloxetine Mylan, Duloxetine Lilly
- Drug Type
- Small Molecule
- Chemical Formula
- C18H19NOS
- CAS Number
- 116539-59-4
- Unique Ingredient Identifier
- O5TNM5N07U
- Background
Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor. It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval for a variety of indications including the tre...
- Indication
Indicated for:
1) Management of Major Depressive Disorder.
2) Management of Generalized Anxiety Disorder.
3) Management of diabetic peripheral neuropathy.
4) Management of fibromyalgia.
5) Management of chronic musculoskeletal pain.
6) Management of osteoarthritis of the knee in adults.
7) Management of chronic lower back pain in adults.
...
- Associated Conditions
- Chronic Lower Back Pain (CLBP), Chronic Musculoskeletal Pain, Diabetic Peripheral Neuropathic Pain (DPN), Fibromyalgia, Generalized Anxiety Disorder, Major Depressive Disorder (MDD), Osteoarthritis of the Knee, Stress Urinary Incontinence (SUI)
- Associated Therapies
- -
The Effect of Central Sensitization on Treatment Response in Patients With Fibromyalgia
- Conditions
- Interventions
- First Posted Date
- 2021-08-25
- Last Posted Date
- 2023-08-15
- Lead Sponsor
- Marmara University
- Target Recruit Count
- 40
- Registration Number
- NCT05020600
- Locations
- 🇹🇷
Feyza Nur YUCEL, İstanbul, Turkey
Efficacy and Safety of Duloxetine in Chinese Solid Tumor Patients With Taxanes-induced Painful Peripheral Neuropathy
- Conditions
- Interventions
- First Posted Date
- 2021-07-21
- Last Posted Date
- 2023-02-15
- Lead Sponsor
- Yan Yang, MD, Ph.D
- Target Recruit Count
- 100
- Registration Number
- NCT04970121
- Locations
- 🇨🇳
Jing Liu, Bengbu, Anhui, China
The Back Pain Consortium Research Program Study
- Conditions
- Interventions
- First Posted Date
- 2021-05-04
- Last Posted Date
- 2024-11-29
- Lead Sponsor
- University of Michigan
- Target Recruit Count
- 494
- Registration Number
- NCT04870957
- Locations
- 🇺🇸
University of Michigan, Ann Arbor, Michigan, United States
Duloxetine vs Pregabalin for Thoracotomy Pain
- First Posted Date
- 2021-03-04
- Last Posted Date
- 2021-06-02
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 75
- Registration Number
- NCT04782310
- Locations
- 🇪🇬
Bassant abdelhamid, Cairo, Egypt
Comparison of Duloxetine Versus Pregabalin
- First Posted Date
- 2021-01-27
- Last Posted Date
- 2021-01-27
- Lead Sponsor
- National Cancer Institute, Egypt
- Target Recruit Count
- 70
- Registration Number
- NCT04727502
- Locations
- 🇪🇬
Nataional Cancer Instituite, Cairo, Egypt
Antidepressant Response in Older Adults With Comorbid PTSD and MDD
- Conditions
- Interventions
- First Posted Date
- 2021-01-06
- Last Posted Date
- 2022-05-11
- Lead Sponsor
- New York State Psychiatric Institute
- Target Recruit Count
- 1
- Registration Number
- NCT04697693
- Locations
- 🇺🇸
New York State Psychiatric Institute, New York, New York, United States
Duloxetine Tibial Plateau
- Conditions
- Interventions
- First Posted Date
- 2020-11-20
- Last Posted Date
- 2022-11-21
- Lead Sponsor
- Boston Medical Center
- Registration Number
- NCT04639011
- Locations
- 🇺🇸
Westchester Medical Center, Valhalla, New York, United States
🇺🇸Boston Medical Center, Boston, Massachusetts, United States
Duloxetine and Neurofeedback Training for the Treatment of Chemotherapy Induced Peripheral Neuropathy
- First Posted Date
- 2020-09-23
- Last Posted Date
- 2024-07-19
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 380
- Registration Number
- NCT04560673
- Locations
- 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
🇺🇸Harris Health System (LBJ), Houston, Texas, United States
Comparison of the Efficacy of Duloxetine and Pregabalin in Patients With Knee Osteoarthritis With Mix Type Pain
- First Posted Date
- 2020-08-31
- Last Posted Date
- 2021-01-25
- Target Recruit Count
- 66
- Registration Number
- NCT04532684
A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain
- First Posted Date
- 2020-08-07
- Last Posted Date
- 2024-11-18
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 1800
- Registration Number
- NCT04504812
- Locations
- 🇺🇸
University of California Davis, Sacramento, California, United States
🇺🇸University of California San Diego, San Diego, California, United States
🇺🇸VA Medical Center San Diego, San Diego, California, United States
Drug Development Updates
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