Duloxetine
- Generic Name
- Duloxetine
- Brand Names
- Cymbalta, Drizalma, Irenka, Yentreve, Duloxetine Zentiva, Duloxetine Mylan, Duloxetine Lilly
- Drug Type
- Small Molecule
- Chemical Formula
- C18H19NOS
- CAS Number
- 116539-59-4
- Unique Ingredient Identifier
- O5TNM5N07U
- Background
Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor. It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval for a variety of indications including the tre...
- Indication
Indicated for:
1) Management of Major Depressive Disorder.
2) Management of Generalized Anxiety Disorder.
3) Management of diabetic peripheral neuropathy.
4) Management of fibromyalgia.
5) Management of chronic musculoskeletal pain.
6) Management of osteoarthritis of the knee in adults.
7) Management of chronic lower back pain in adults.
...
- Associated Conditions
- Chronic Lower Back Pain (CLBP), Chronic Musculoskeletal Pain, Diabetic Peripheral Neuropathic Pain (DPN), Fibromyalgia, Generalized Anxiety Disorder, Major Depressive Disorder (MDD), Osteoarthritis of the Knee, Stress Urinary Incontinence (SUI)
- Associated Therapies
- -
Levomilnacipran in Healthy Males
- Conditions
- Interventions
- First Posted Date
- 2017-08-15
- Last Posted Date
- 2021-10-06
- Lead Sponsor
- University of Ottawa
- Target Recruit Count
- 36
- Registration Number
- NCT03249311
- Locations
- 🇨🇦
Institute of Mental Health Research, Royal Ottawa Mental Health Centre, Ottawa, Ontario, Canada
A Diagnosis and Treatment Optimization Study of Depression Based on the Neurological Mechanism of Reward System
- Conditions
- Interventions
- First Posted Date
- 2017-05-11
- Last Posted Date
- 2019-12-13
- Lead Sponsor
- Peking University
- Target Recruit Count
- 120
- Registration Number
- NCT03148522
- Locations
- 🇨🇳
Yun-Ai SU, Beijing, Beijing, China
Efficacy and Safety of Duloxetine Among Individuals With Depressive Disorder in a 12 Weeks Trial
- First Posted Date
- 2017-04-20
- Last Posted Date
- 2017-04-20
- Lead Sponsor
- Taichung Veterans General Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT03121573
Neurobiology of Treatment Responses in MDD
- First Posted Date
- 2017-03-01
- Last Posted Date
- 2023-04-24
- Lead Sponsor
- University of Utah
- Registration Number
- NCT03068247
- Locations
- 🇺🇸
University of Utah, Salt Lake City, Utah, United States
Impact of Duloxetine on Male Fertility
- First Posted Date
- 2017-02-01
- Last Posted Date
- 2020-03-12
- Lead Sponsor
- Weill Medical College of Cornell University
- Target Recruit Count
- 69
- Registration Number
- NCT03038867
- Locations
- 🇺🇸
Weill Cornell Medicine, New York, New York, United States
Duloxetine for Succinylcholine-induced Postoperative Myalgia
- Conditions
- Interventions
- First Posted Date
- 2017-01-31
- Last Posted Date
- 2020-10-19
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 70
- Registration Number
- NCT03037073
- Locations
- 🇪🇬
Assiut university hospital, Assiut, Egypt
Brain Morphometry in OA Patients Treated With Duloxetine
- Conditions
- Interventions
- First Posted Date
- 2016-09-16
- Last Posted Date
- 2017-03-07
- Lead Sponsor
- Northwestern University
- Target Recruit Count
- 21
- Registration Number
- NCT02903238
- Locations
- 🇺🇸
Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies
- Conditions
- First Posted Date
- 2016-09-08
- Last Posted Date
- 2024-03-12
- Lead Sponsor
- University of New Mexico
- Target Recruit Count
- 1037352
- Registration Number
- NCT02893371
- Locations
- 🇺🇸
Christophe G Lambert, Albuquerque, New Mexico, United States
Treatment Outcome in Major Depressive Disorder
- First Posted Date
- 2016-08-16
- Last Posted Date
- 2019-10-16
- Lead Sponsor
- Rigshospitalet, Denmark
- Target Recruit Count
- 100
- Registration Number
- NCT02869035
- Locations
- 🇩🇰
Neurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark
A Multidisciplinary Approach to Manage Gait Difficulty in Parkinson Patients
- Conditions
- Interventions
- First Posted Date
- 2016-08-05
- Last Posted Date
- 2017-12-12
- Lead Sponsor
- University of Chicago
- Registration Number
- NCT02857244
- Locations
- 🇺🇸
University of Chicago Medical Center, Chicago, Illinois, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.