Colchicine
- Generic Name
- Colchicine
- Brand Names
- Colcrys, Gloperba, Lodoco, Mitigare
- Drug Type
- Small Molecule
- Chemical Formula
- C22H25NO6
- CAS Number
- 64-86-8
- Unique Ingredient Identifier
- SML2Y3J35T
- Background
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammatory and fibrotic conditions.
- Indication
Colchicine is indicated for the prophylaxis and treatment of gout flares. It is also indicated in Familial Mediterranean fever (FMF) in children and adults of four years of age and older. It is also indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established atherosclerotic disease or with multiple risk factors for cardiovascular disease.
Some off-label uses of colchicine include the treatment of the manifestations of Behcet's syndrome, pericarditis, and postpericardiotomy syndrome.
- Associated Conditions
- Behcet's Syndrome, Cardiovascular Mortality, Coronary Revascularization, Familial Mediterranean Fever (FMF ), Gout Flares, Myocardial Infarction, Pericarditis, Postpericardiotomy Syndrome, Stroke
Apolipoprotein CIII Reduction Via Colchicine
- First Posted Date
- 2014-03-11
- Last Posted Date
- 2014-05-30
- Lead Sponsor
- Scripps Translational Science Institute
- Target Recruit Count
- 5
- Registration Number
- NCT02083510
- Locations
- 🇺🇸
Scripps Translational Science Institute, La Jolla, California, United States
Evaluate the Efficacy and Safety of Arhalofenate for Preventing Flares and Reducing Serum Uric Acid in Gout Patients
- Conditions
- Gout
- Interventions
- First Posted Date
- 2014-02-17
- Last Posted Date
- 2018-01-29
- Lead Sponsor
- CymaBay Therapeutics, Inc.
- Target Recruit Count
- 248
- Registration Number
- NCT02063997
Immune Molecular and Inflammatory Cytokines Dysfunction Analysis in Gout Patients With Different Urate Levels
- First Posted Date
- 2014-02-12
- Last Posted Date
- 2014-05-08
- Lead Sponsor
- Tongji Hospital
- Target Recruit Count
- 96
- Registration Number
- NCT02060552
- Locations
- 🇨🇳
Yikai YU, Wuhan, Hubei, China
Low-dose Colchicine in Patients With Type 2 Diabetes Mellitus and Microalbuminuria
- Conditions
- Diabetic Nephropathy
- Interventions
- Drug: placebo 0.5mg/d
- First Posted Date
- 2014-01-14
- Last Posted Date
- 2019-01-31
- Lead Sponsor
- Chongqing Medical University
- Target Recruit Count
- 160
- Registration Number
- NCT02035891
- Locations
- 🇨🇳
The First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing, China
Colchicine Or Naproxen Treatment for ACute gouT
- First Posted Date
- 2013-11-25
- Last Posted Date
- 2019-06-18
- Lead Sponsor
- Keele University
- Target Recruit Count
- 399
- Registration Number
- NCT01994226
- Locations
- 🇬🇧
Keele University, Stoke-on-Trent, United Kingdom
Colchicine For Prevention of Perioperative Atrial Fibrillation in Patients Undergoing Thoracic Surgery Pilot Study
- Conditions
- Atrial FibrillationThoracic Surgery
- Interventions
- First Posted Date
- 2013-11-15
- Last Posted Date
- 2021-11-05
- Lead Sponsor
- Population Health Research Institute
- Target Recruit Count
- 100
- Registration Number
- NCT01985425
- Locations
- 🇨🇦
St. Joseph Healthcare, St. Joseph Hospital, Hamilton, Ontario, Canada
🇨🇦University of Manitoba Health Sciences Centre, Winnipeg, Manitoba, Canada
Colchicine in ST-elevation Myocardial Infarction
- Conditions
- Acute Myocardial Infarction
- Interventions
- First Posted Date
- 2013-09-06
- Last Posted Date
- 2015-04-23
- Lead Sponsor
- G.Gennimatas General Hospital
- Target Recruit Count
- 150
- Registration Number
- NCT01936285
- Locations
- 🇬🇷
Athens General Hospital "G. Gennimatas", Athens, Greece
Effect of Colchicine for the Palliative Management of Hepatocellular Carcinoma
- First Posted Date
- 2013-09-05
- Last Posted Date
- 2020-08-19
- Target Recruit Count
- 15
- Registration Number
- NCT01935700
- Locations
- 🇨🇳
Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Colchicine for Acute Coronary Syndromes
- First Posted Date
- 2013-07-24
- Last Posted Date
- 2013-07-24
- Lead Sponsor
- Maria Vittoria Hospital
- Target Recruit Count
- 500
- Registration Number
- NCT01906749
- Locations
- 🇮🇹
Cardiology Dpt.Maria Vittoria Hospital, Torino, Italy
🇮🇹Cardiology Dpt.San Giovanni Bosco Hospital, Torino, Italy
🇮🇹Cardiology Dpt., Rivoli, Torino, Italy
Anti-inflammatory Effects of Colchicine in PCI
- First Posted Date
- 2012-10-18
- Last Posted Date
- 2022-05-25
- Lead Sponsor
- NYU Langone Health
- Target Recruit Count
- 280
- Registration Number
- NCT01709981
- Locations
- 🇺🇸
Bellevue Hospital Center, New York, New York, United States
🇺🇸Manhattan VA Hospital, New York, New York, United States
🇺🇸New York Langone Medical Center, New York, New York, United States
Drug Development Updates
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