Colchicine
- Generic Name
- Colchicine
- Brand Names
- Colcrys, Gloperba, Lodoco, Mitigare
- Drug Type
- Small Molecule
- Chemical Formula
- C22H25NO6
- CAS Number
- 64-86-8
- Unique Ingredient Identifier
- SML2Y3J35T
- Background
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammato...
- Indication
Colchicine is indicated for the prophylaxis and treatment of gout flares. It is also indicated in Familial Mediterranean fever (FMF) in children and adults of four years of age and older. It is also indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established ather...
- Associated Conditions
- Behcet's Syndrome, Cardiovascular Mortality, Coronary Revascularization, Familial Mediterranean Fever (FMF ), Gout Flares, Myocardial Infarction, Pericarditis, Postpericardiotomy Syndrome, Stroke
- Associated Therapies
- -
The COlchicine HypERtENsion Trial
- First Posted Date
- 2021-06-07
- Last Posted Date
- 2023-02-28
- Lead Sponsor
- Herlev and Gentofte Hospital
- Target Recruit Count
- 150
- Registration Number
- NCT04916522
- Locations
- 🇩🇰
Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev and Gentofte Hospital, Hellerup, Denmark
Post-Ablation Pericarditis Reduction Study
- Conditions
- Interventions
- First Posted Date
- 2021-05-28
- Last Posted Date
- 2022-11-08
- Lead Sponsor
- St. Vincent Cardiovascular Research Institute
- Target Recruit Count
- 248
- Registration Number
- NCT04906720
- Locations
- 🇺🇸
Ascension St Vincent Hospital, Indianapolis, Indiana, United States
Colchicine for Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement
- Conditions
- Interventions
- First Posted Date
- 2021-05-03
- Last Posted Date
- 2024-10-30
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 200
- Registration Number
- NCT04870424
- Locations
- 🇨🇭
Inselspital, Bern University Hospital, Department of Cardiology, Bern, Switzerland
Colchicine in HFpEF
- Conditions
- Interventions
- First Posted Date
- 2021-04-23
- Last Posted Date
- 2023-04-26
- Lead Sponsor
- Montreal Heart Institute
- Target Recruit Count
- 14
- Registration Number
- NCT04857931
- Locations
- 🇨🇦
Montreal Heart Institute, Montréal, Quebec, Canada
Colchicine for the Stability of Coronary Plaque in Acute Coronary Syndrome (COLOCT)
- First Posted Date
- 2021-04-19
- Last Posted Date
- 2023-12-19
- Lead Sponsor
- Wuhan Union Hospital, China
- Target Recruit Count
- 128
- Registration Number
- NCT04848857
- Locations
- 🇨🇳
Wuhan Union Hospital, Wuhan, Hubei, China
Colchicine for the Treatment of Cardiac Injury in Hospitalized Patients With COVID-19 (COLHEART-19)
- First Posted Date
- 2021-02-21
- Last Posted Date
- 2022-07-25
- Lead Sponsor
- Baptist Health South Florida
- Target Recruit Count
- 2
- Registration Number
- NCT04762771
- Locations
- 🇺🇸
Baptist Hospital of Miami, Miami, Florida, United States
Survival TRial Using CytoKines in COVID-19 (STRUCK Trial)
- Conditions
- Interventions
- First Posted Date
- 2021-01-26
- Last Posted Date
- 2022-07-28
- Lead Sponsor
- University of Sao Paulo
- Target Recruit Count
- 60
- Registration Number
- NCT04724629
- Locations
- 🇧🇷
Hospital e Maternidade Christovão da Gama, Santo André, SP, Brazil
🇧🇷Faculdade de Medicina de Ribeirão Preto - USP, Ribeirão Preto, SP, Brazil
Study to Investigate the Treatment Effect of Colchicine in Patients With COVID-19
- First Posted Date
- 2020-12-16
- Last Posted Date
- 2023-01-05
- Lead Sponsor
- Ayub Teaching Hospital
- Target Recruit Count
- 102
- Registration Number
- NCT04667780
- Locations
- 🇵🇰
Ayub Teaching Hospital, Abbottabad, Khyber Pakhtunkhwa, Pakistan
Colchicine in Moderate Symptomatic COVID-19 Patients
- First Posted Date
- 2020-08-26
- Last Posted Date
- 2021-01-11
- Lead Sponsor
- Dhaka Medical College
- Target Recruit Count
- 299
- Registration Number
- NCT04527562
- Locations
- 🇧🇩
Dhaka Medical College Hospital, Dhaka-1000, Bangladesh
Anti-Inflammatory Treatment of Uremic Cardiomyopathy With Colchicine
- First Posted Date
- 2020-08-05
- Last Posted Date
- 2024-06-20
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 20
- Registration Number
- NCT04500665
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.