Carbon dioxide

Overview

Carbon dioxide is a colorless, odorless gas vital to life on Earth. This naturally occurring chemical compound is composed of a carbon atom covalently double bonded to two oxygen atoms. Medical Carbon Dioxide is a liquefied medicinal gas, supplied in cylinders filled to a high pressure. Medical Carbon Dioxide may be used in different situations, e.g. during bodily investigations, to inflate body cavities during surgery (such as key-hole surgery), and in solid form (dry ice) for freezing of tissue and removal of warts.

Indication

Carbon dioxide is commonly used as an insufflation gas for minimal invasive surgery (laparoscopy, endoscopy, and arthroscopy) to enlarge and stabilize body cavities to provide better visibility of the surgical area. It has been used also in cryotherapy and as respiratory stimulant before and after anesthesia. It could be used also in expansion of blood vessels if required, to increase carbon dioxide level after rapid breathing, and to stimulate breathing after a period of nonbreathing.

Associated Conditions

Hypoplastic Left Heart Syndrome (HLHS)
Laryngeal Injuries

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Oxygen Toxicity: Mechanisms in Humans	2023/03/09	NCT05761756	Not Applicable	Recruiting	Duke University
Metabolic and Hemodynamic Reserve in Pediatric SCA	2020/05/28	NCT04406818	Not Applicable	Recruiting	Washington University School of Medicine
Carbon Dioxide Versus Air Insufflation for the Application of Argon Plasma to Reduce the Gastrojejunal Anastomosis	2017/08/28	NCT03264027	Not Applicable	Completed	Kaiser Clinic and Hospital
Comparison Between Two Different Distention Medium in Diagnostic Hysteroscopy	2016/11/08	NCT02958722	Not Applicable	Completed	Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Predictors of Opioid-Induced Respiratory Depression (OIRD)	2015/06/16	NCT02473354	Phase 1	Completed	Duke University
Market Potential of Carbon Dioxide Nasal Spray	2014/04/14	NCT02113449	Phase 2	Completed	GlaxoSmithKline

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Carbon Dioxide	AIRGAS NOR PAC INC	57472-004	RESPIRATORY (INHALATION)	992 mL in 1 L	5/10/2011
Carbon Dioxide	Linde Gas & Equipment Inc.	25373-004	RESPIRATORY (INHALATION)	99 L in 100 L	11/15/2017
Carbon Dioxide	Airgas Usa, LLC	11054-130	RESPIRATORY (INHALATION)	992 mL in 1 L	1/26/2022
Carbon Dioxide	AGL Inhalation Therapy Co.	17575-104	RESPIRATORY (INHALATION)	990 mL in 1 L	10/6/2023
Carbon Dioxide-Oxygen Mixture	Roberts Oxygen Company, Inc.	46123-121	RESPIRATORY (INHALATION)	100 mL in 1 L	11/19/2020
COMPRESSED GAS, OXIDIZING, N.O.S.	Medical-Technical Gases, Inc.	10736-009	RESPIRATORY (INHALATION)	5 mL in 1 L	12/22/2012
COMPRESSED GAS, OXIDIZING, N.O.S.	Medical-Technical Gases, Inc.	10736-010	RESPIRATORY (INHALATION)	5 mL in 1 L	12/22/2012
Carbon Dioxide Air Mix	Medical-Technical Gases, Inc.	10736-012	RESPIRATORY (INHALATION)	10 mL in 1 L	12/22/2012
Carbon Dioxide	AIRGAS THERAPEUTICS LLC	82605-001	RESPIRATORY (INHALATION)	1 g in 1 g	10/6/2023
Carbon Dioxide	Red Ball Oxygen Co., Inc.	46362-004	RESPIRATORY (INHALATION)	990 mL in 1 L	10/18/2023

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
CARBON DIOXIDE, MEDICAL	34463	BOC Limited	Medicine	A	1/2/1992
Coregas Pty Ltd medical carbon dioxide 100% v/v gas in gas cylinder	27190	Coregas Pty Ltd	Medicine	A	10/21/1991
CARBOGEN 5% CARBON DIOXIDE IN OXYGEN MIXTURE	34469	BOC Limited	Medicine	A	1/2/1992
CARBANOX medical carbon dioxide 5% v/v and oxygen 95% v/v gas in gas cylinder	27180	Coregas Pty Ltd	Medicine	A	10/21/1991
MEDICAL SPECIAL GAS MIXTURES	34465	BOC Limited	Medicine	A	1/2/1992
AIR LIQUIDE AUSTRALIA LIMITED Carbon Dioxide 100% v/v Gas Medicinal	32742	Air Liquide Australia Limited	Medicine	A	11/1/1991

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
CARBON DIOXIDE IN OXYGEN MIXTURE	matheson gas products canada inc.	00460907	Gas - Inhalation	10 %	12/31/1983
CARBON DIOXIDE 1% W OXYGEN	liquid carbonic inc.	00882747	Gas - Inhalation	7 %	12/31/1990
CARBON DIOXIDE 99%	air products canada ltd/ltée.	00802166	Gas - Laboratory Test	99.0 %	12/31/1988
CARBON DIOXIDE USP, COMPRESSED AIR USP M.G.M	Praxair Canada Inc	02014335	Gas - Inhalation	50 %	12/31/1993
CARBON DIOXIDE 100%	Air Liquide Canada Inc.	00572861	Gas - Inhalation	100 %	12/31/1911
CARBON DIOXIDE MIXTURE	liquid carbonic inc.	00882690	Gas - Inhalation	12 %	12/31/1990
CARBON DIOXIDE USP	Linde Canada Inc	02014459	Gas - Inhalation	99 %	12/31/1993
OXYGEN CARBON DIOXIDE MIXTURE	Air Liquide Canada Inc.	00572853	Gas - Inhalation	5 %	12/31/1911
CARBON DIOXIDE 23.1% W OXYGEN	Praxair Canada Inc	00882771	Gas - Inhalation	50 %	12/30/1970
CARBON DIOXIDE, COMPRESSED AIR MEDICAL G.MIX.	Praxair Canada Inc	02014343	Gas - Inhalation	15 %	12/31/1993

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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