Pembrolizumab is a highly selective IgG4-kappa humanized monoclonal antibody against PD-1 receptors. It was generated by grafting the variable sequences of a very high-affinity mouse antihuman PD-1 antibody onto a human IgG4-kappa isotype containing a stabilizing S228P Fc mutation. It contains 32 cysteine residues and the complete folded molecule includes 4 disulfide linkages as interchain bonds and 23 interchain bonds. It was developed by Merck & Co and first approved for the treatment of metastatic malignant melanoma by the FDA on September 4, 2014, becoming the first approved therapy against PD-1. In the time since its initial approval, pembrolizumab has been granted approval in the treatment of a wide variety of cancers.
Pembrolizumab is indicated for the following conditions:
For all approved adult indications, pembrolizumab may be used for an additional 6 weeks at 400mg weekly.
Montpellier - CHU, Montpellier, France
Centre Antoine Lacassagne, Nice, France
AP-HP Hôpital Cochin, Paris, France
Hospital Virgen del Rocío, Sevilla, Spain
Hospital General de Valencia, Valencia, Spain
Institut Català D'Oncologia - Badalona, Badalona, Barcelona, Spain
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China
Sun yat-sen university cancer center, Guangzhou, Guangdong, China
Sun Yat-sen Memorial Hospital, Guangzhou, Guangdong, China
University of Miami, Miami, Florida, United States
University of California, San Francisco, San Francisco, California, United States
Tongji Hospital, Wuhan, Hubei, China
Breast Cancer Center Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China
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