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Diclofenac

Generic Name
Diclofenac
Brand Names
Aleve Arthritis Pain, Arthrotec, Cambia, Cataflam, Flector, Licart, Lofena, Pennsaid, Previdolrx Analgesic Pak, Salonpas Pain Relieving Patch, Solaraze, Voltaren, Voltaren Emulgel, Xrylix, Zipsor, Zorvolex
Drug Type
Small Molecule
Chemical Formula
C14H11Cl2NO2
CAS Number
15307-86-5
Unique Ingredient Identifier
144O8QL0L1
Background

Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and inflammation from a variety of causes. Diclofenac was the product of rational drug design based on the structures of phenylbutazone, mefenamic acid, and indomethacin. The addition of two chlorine groups in the ortho position of the phenyl ring locks the ring in maximal torsion which appears to be related to increased potency. It is often used in combination with misoprostol to prevent NSAID-induced gastric ulcers. Diclofenac was first approved by the FDA in July 1988 under the trade name Voltaren, marketed by Novartis (previously Ciba-Geigy).

Indication

Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. It is often used in combination with misoprostol as a gastro-protective agent in patients with high risk of developing NSAID-induced ulcers.

Associated Conditions
Actinic Keratosis (AK), Acute Arthritis, Acute Gouty Arthritis, Acute Migraine, Acute Musculoskeletal Pain, Ankylosing Spondylitis (AS), Common Cold, Fever, Gout, Inflammation, Inflammatory Disease of the Oral Cavity, Inflammatory Disease of the throat, Inflammatory Reaction of the Nerve, Joint Pain, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Muscle Inflammation, Myalgia, Neuropathic Pain, Ocular Inflammation, Osteoarthritis (OA), Osteoarthritis of the Knee, Pain, Pain caused by Rheumatism, Pericarditis, Photophobia, Postoperative Inflammatory Response, Postoperative pain, Primary Dysmenorrhoea, Radicular Pain, Rheumatism, Rheumatoid Arthritis, Seasonal Allergic Conjunctivitis, Spinal pain, Tendon pain, Vertebral column pain, Acute Musculoskeletal injury, Acute, moderate, severe Pain, Inflammatory, Localized soft tissue rheumatism, Mild to moderate joint pain, Mild to moderate pain, Minor pain, Perioperative miosis
Associated Therapies
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Diclofenac for the Treatment of Patients with Metastatic Non-small Cell Lung Cancer on Single Agent Immunotherapy

Phase 2
Not yet recruiting
Conditions
Advanced Lung Non-Small Cell Carcinoma
Metastatic Lung Non-Small Cell Carcinoma
Stage III Lung Cancer AJCC V8
Stage IV Lung Cancer AJCC V8
Interventions
Biological: Atezolizumab
Procedure: Biospecimen Collection
Biological: Cemiplimab
Procedure: Computed Tomography
Drug: Diclofenac Potassium
Other: Electronic Health Record Review
Procedure: Magnetic Resonance Imaging
Biological: Nivolumab
Biological: Pembrolizumab
Procedure: Positron Emission Tomography
First Posted Date
2024-12-12
Last Posted Date
2024-12-12
Lead Sponsor
Emory University
Target Recruit Count
20
Registration Number
NCT06731270
Locations
🇺🇸

Emory University Hospital Midtown, Atlanta, Georgia, United States

🇺🇸

Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia, United States

Topical Treatments for Ankle Sprains

Active, not recruiting
Conditions
Ankle Sprain
Interventions
Drug: Etofenamat
Drug: Diclofenac
First Posted Date
2024-10-02
Last Posted Date
2024-10-02
Lead Sponsor
Ankara City Hospital Bilkent
Target Recruit Count
100
Registration Number
NCT06623929
Locations
🇹🇷

Ankara Etlik City Hospital, Ankara, Turkey

KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism

First Posted Date
2024-08-22
Last Posted Date
2024-08-22
Lead Sponsor
Helsinki University Central Hospital
Target Recruit Count
12
Registration Number
NCT06566794
Locations
🇫🇮

Department of Clinical Pharmacology, Helsinki, Finland

Evaluation of the Effect of Intra-ligamentary Injection of Diclofenac Potassium Versus Articaine on Anaesthetic Efficacy in Mandibular Molars With Symptomatic Irreversible Pulpitis.

Early Phase 1
Not yet recruiting
Conditions
Teeth With Acute Irreverseble Pulpitis
Interventions
First Posted Date
2024-07-15
Last Posted Date
2024-08-06
Lead Sponsor
Cairo University
Target Recruit Count
40
Registration Number
NCT06500871

NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow

Phase 4
Recruiting
Conditions
Elbow Pain
Chronic Pain
Interventions
Drug: Diclofenac
Drug: Tramadol
Other: Acetaminophen
First Posted Date
2024-04-18
Last Posted Date
2024-08-22
Lead Sponsor
The Cleveland Clinic
Target Recruit Count
92
Registration Number
NCT06373978
Locations
🇺🇸

The Cleveland Clinic Florida, Coral Springs, Florida, United States

🇺🇸

The Cleveland Clinic Ohio, Avon, Ohio, United States

The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain

Not Applicable
Not yet recruiting
Conditions
Symptomatic Irreversible Pulpitis
Interventions
Drug: Trypsin, Bromelain and Rutoside
Other: Placebo
Drug: Prednisolone Oral Tablet
Drug: Diclofenac Potassium
First Posted Date
2024-03-07
Last Posted Date
2024-03-07
Lead Sponsor
Cairo University
Target Recruit Count
120
Registration Number
NCT06298383

Comparative Analysis of Radiotherapeutic and Medical Procedures for the Prophylaxis of Heterotopic Ossifications

Completed
Conditions
Hip Arthropathy
Heterotopic Ossification
Myositis Ossificans Traumatica, Thigh
Interventions
Radiation: Radiation
Drug: Diclofenac
First Posted Date
2024-02-09
Last Posted Date
2024-02-09
Lead Sponsor
University of Jena
Target Recruit Count
512
Registration Number
NCT06251349
Locations
🇩🇪

Department of Radiooncology, Jena, Jena, Germany

Efficacy of Single Dose Rectal Diclofenac With Oral Diclofenac for the Relief of Perineal Pain Within 24 Hours After Episiotomy

Not Applicable
Completed
Conditions
Pain Relief After Episiotomy
Interventions
First Posted Date
2024-01-23
Last Posted Date
2024-01-23
Lead Sponsor
Federal Teaching Hospital Abakaliki
Target Recruit Count
146
Registration Number
NCT06220279
Locations
🇳🇬

Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi, Nigeria

🇳🇬

Federal Teaching Hospital, Abakaliki, Abakaliki, Ebonyi, Nigeria

The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament

Phase 2
Recruiting
Conditions
Pulp Disease, Dental
Endodontic Disease
Intracanal Medication
Interventions
First Posted Date
2024-01-16
Last Posted Date
2024-01-17
Lead Sponsor
British University In Egypt
Target Recruit Count
48
Registration Number
NCT06207253
Locations
🇪🇬

British university in Egypt, Cairo, Egypt

Comparative Evaluation of the Effectiveness of Diclofenac Sodium Versus Vitamin D on Myofascial Pain

Phase 4
Completed
Conditions
Myofascial Pain Dysfunction Syndrome,Temporomandibular Joint
Interventions
Dietary Supplement: Vitamin D
Drug: Diclofenac Sodium
First Posted Date
2023-11-01
Last Posted Date
2023-11-03
Lead Sponsor
Yuzuncu Yıl University
Target Recruit Count
40
Registration Number
NCT06111573
Locations
🇹🇷

Van Yüzüncü Yıl University, Van, Turkey

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