Didanosine
- Generic Name
- Didanosine
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C10H12N4O3
- CAS Number
- 69655-05-6
- Unique Ingredient Identifier
- K3GDH6OH08
- Background
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse tra...
- Indication
For use, in combination with other antiretroviral agents, in the treatment of HIV-1 infection in adults.
- Associated Conditions
- Human Immunodeficiency Virus Type 1 (HIV-1) Infection
- Associated Therapies
- -
A Study of ddI in Children With AIDS Who Have Not Had Success With Zidovudine
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2011-08-05
- Lead Sponsor
- Bristol-Myers Squibb
- Registration Number
- NCT00002280
- Locations
- 🇺🇸
Bristol - Myers Squibb Co, Wallingford, Connecticut, United States
A Study to Evaluate the Use of a Protease Inhibitor and of Interleukin-2 (IL-2) in the Treatment of Early HIV Infection
- Conditions
- Interventions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2013-09-06
- Target Recruit Count
- 165
- Registration Number
- NCT00006154
- Locations
- 🇨🇦
Centre Hospitalier de la Universite de Montreal (CHUM), Montreal, Quebec, Canada
🇨🇦Centre de traitment d'immunodeficience, Montreal, Quebec, Canada
🇨🇦Viridae Clinical Sciences / University of British Columbia, Vancouver, British Columbia, Canada
An Efficacy Study of 2',3'-Dideoxyinosine (ddI) (BMY-40900) Administered Orally Twice Daily to Zidovudine Intolerant Patients With AIDS or AIDS-Related Complex
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2011-03-14
- Target Recruit Count
- 660
- Registration Number
- NCT00000672
- Locations
- 🇺🇸
Northwestern Univ Med School, Chicago, Illinois, United States
🇺🇸UCLA Med Ctr / Pediatric, Los Angeles, California, United States
🇺🇸Johns Hopkins Hosp, Baltimore, Maryland, United States
Comparison of Three Anti-HIV Drug Combinations in HIV-Infected Patients With No Symptoms of the Disease
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 300
- Registration Number
- NCT00001045
- Locations
- 🇺🇸
St Paul Ramsey Med Ctr, Saint Paul, Minnesota, United States
🇺🇸Adirondack Med Ctr at Saranac Lake, Albany, New York, United States
🇺🇸Mid - Hudson Care Ctr, Albany, New York, United States
A Study of Chemotherapy Plus ddI or ddC in the Treatment of AIDS-Related Kaposi's Sarcoma
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-10-29
- Target Recruit Count
- 72
- Registration Number
- NCT00000954
- Locations
- 🇺🇸
USC CRS, Los Angeles, California, United States
🇺🇸Ucsf Aids Crs, San Francisco, California, United States
🇺🇸UCLA CARE Center CRS, Los Angeles, California, United States
Safety and Effectiveness of an Anti-HIV Drug Combination With and Without Hydroxyurea in Patients With Early HIV Infection
- Conditions
A Study on the Management of Combination Anti-HIV Drug Therapy in HIV-Positive Children With Prior Treatment
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-10-29
- Target Recruit Count
- 217
- Registration Number
- NCT00000902
- Locations
- 🇺🇸
Connecticut Children's Med Ctr, Farmington, Connecticut, United States
🇺🇸Cedars Sinai / UCLA Med Ctr, Los Angeles, California, United States
🇺🇸Harbor - UCLA Med Ctr / UCLA School of Medicine, Los Angeles, California, United States
Simplified Drug Regimens for HIV Patients in ACTG 388 or Patients Who Responded to A First Potent Combination Regimen
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2013-07-29
- Target Recruit Count
- 240
- Registration Number
- NCT00014937
- Locations
- 🇮🇹
Spedali Civili - Carosi, Brescia, Italy
🇺🇸Rush Presbyterian - Saint Luke's Med Ctr, Chicago, Illinois, United States
🇺🇸Univ of Southern California / LA County USC Med Ctr, Los Angeles, California, United States
A Randomized Comparative Trial of Zidovudine (AZT) Versus 2',3'-Dideoxyinosine (ddI) Versus AZT Plus ddI in Symptomatic HIV-Infected Children
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-02
- Target Recruit Count
- 819
- Registration Number
- NCT00000637
- Locations
- 🇺🇸
Children's Med Ctr of Dallas, Dallas, Texas, United States
🇺🇸Univ of Maryland at Baltimore / Univ Med Ctr, Baltimore, Maryland, United States
🇺🇸UCLA Med Ctr / Pediatric, Los Angeles, California, United States
A Study of the Safety and Effectiveness of Treating Advanced AIDS Patients Between Ages 4 and 22 With 7 Drugs, Some at Higher Than Usual Doses
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 6
- Registration Number
- NCT00001108
- Locations
- 🇺🇸
Cook County Hosp, Chicago, Illinois, United States
🇺🇸Univ of Massachusetts Med School, Worcester, Massachusetts, United States
🇺🇸Univ of Mississippi Med Ctr, Jackson, Mississippi, United States
Drug Development Updates
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