Baclofen
- Generic Name
- Baclofen
- Brand Names
- Fleqsuvy, Gablofen, Kemstro, Lioresal, Lyvispah, Ozobax
- Drug Type
- Small Molecule
- Chemical Formula
- C10H12ClNO2
- CAS Number
- 1134-47-0
- Unique Ingredient Identifier
- H789N3FKE8
- Background
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FD...
- Indication
Oral baclofen is indicated for the treatment of spasticity resulting from multiple sclerosis and is particularly useful for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. It may also be used to treat patients with spinal cord injuries and other spinal cord diseases. Baclofen should not be used to treat skeletal muscle spasms...
- Associated Conditions
- Alcohol Dependency, Severe Spasticity, Spasticity, Flexor spasm, Severe cerebral origin Spasticity, Severe spinal cord origin Spasticity
- Associated Therapies
- -
Baclofen in the Treatment of Muscle Cramps in Patients With Cirrhosis
- First Posted Date
- 2014-08-20
- Last Posted Date
- 2014-10-06
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 100
- Registration Number
- NCT02221570
- Locations
- 🇪🇬
Tanta University Hospital, Tanta, Gharbia, Egypt
Novel Topical Therapies for the Treatment of Genital Pain
- Conditions
- Interventions
- First Posted Date
- 2014-03-28
- Last Posted Date
- 2016-07-15
- Lead Sponsor
- University of Rochester
- Target Recruit Count
- 9
- Registration Number
- NCT02099006
- Locations
- 🇺🇸
University of Rochester, Rochester, New York, United States
Preventing Alcohol Withdrawal Syndrome With Oral Baclofen
- First Posted Date
- 2014-02-03
- Last Posted Date
- 2018-05-23
- Lead Sponsor
- Denver Health and Hospital Authority
- Target Recruit Count
- 102
- Registration Number
- NCT02052440
- Locations
- 🇺🇸
Denver Health Hospital, Denver, Colorado, United States
Baclofen Effects on Marijuana Dependence
- Conditions
- Interventions
- First Posted Date
- 2013-12-13
- Last Posted Date
- 2017-06-14
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 47
- Registration Number
- NCT02011516
- Locations
- 🇺🇸
University of Pennsylvania Center for Studies of Addiction, Philadelphia, Pennsylvania, United States
A Study to Examine the, Safety, Tolerability and Pharmacokinetics Co-Administered Baclofen and Memantine in Obese and Lean, Otherwise Healthy Adults
- Conditions
- Interventions
- First Posted Date
- 2013-12-05
- Last Posted Date
- 2014-07-08
- Lead Sponsor
- Gedeon Richter Plc.
- Registration Number
- NCT02001584
- Locations
- 🇬🇧
Quintiles Drug Research Unit at Guy's Hospital, London, United Kingdom
Efficacy and Safety of High Dose Baclofen for Alcohol Dependence
- First Posted Date
- 2013-11-11
- Last Posted Date
- 2019-06-12
- Lead Sponsor
- University of North Carolina, Chapel Hill
- Target Recruit Count
- 120
- Registration Number
- NCT01980706
- Locations
- 🇺🇸
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
Recurrent Crying Spells in Cerebral Palsy
- First Posted Date
- 2013-10-07
- Last Posted Date
- 2013-10-08
- Lead Sponsor
- Sathbhavana Brain Clinic
- Target Recruit Count
- 70
- Registration Number
- NCT01955655
- Locations
- 🇮🇳
Sathbhavana Brain Clinic, Secunderabad, Andhra Pradesh, India
Preventing Alcohol Withdrawal With Oral Baclofen
- First Posted Date
- 2013-09-09
- Last Posted Date
- 2017-05-05
- Lead Sponsor
- Essentia Health
- Target Recruit Count
- 17
- Registration Number
- NCT01937364
- Locations
- 🇺🇸
St. Mary's Medical Center, Duluth, Minnesota, United States
🇺🇸Essentia Health Innovis Hospital, Fargo, North Dakota, United States
Baclofen Effects in Cigarette Smokers
- First Posted Date
- 2013-04-01
- Last Posted Date
- 2018-12-19
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 44
- Registration Number
- NCT01821560
- Locations
- 🇺🇸
University of Pennsylvania Center for Studies of Addiction, Philadelphia, Pennsylvania, United States
Baclofen for Treating Anxiety and Alcoholism
- Conditions
- Interventions
- First Posted Date
- 2012-12-18
- Last Posted Date
- 2017-09-18
- Target Recruit Count
- 39
- Registration Number
- NCT01751386
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Drug Development Updates
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