Octafluoropropane
- Generic Name
- Octafluoropropane
- Brand Names
- Definity, Luminity, Optison
- Drug Type
- Small Molecule
- Chemical Formula
- C3F8
- CAS Number
- 76-19-7
- Unique Ingredient Identifier
- CK0N3WH0SR
- Background
Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.
- Indication
Used as an ultrasound contrast imaging in cardiology and radiology.
DEF-314 Better Accuracy in Ejection Fraction (EF) Assessment With DEFINITY
- First Posted Date
- 2018-06-27
- Last Posted Date
- 2020-12-17
- Lead Sponsor
- Lantheus Medical Imaging
- Target Recruit Count
- 153
- Registration Number
- NCT03571672
- Locations
- 🇺🇸
Alfieri Cardiology, Wilmington, Delaware, United States
🇺🇸Banner University of Arizona Medical Center, Tucson, Arizona, United States
🇺🇸Weill Cornell Medical Center, New York, New York, United States
Academic-Industrial Partnership for Translation of Acoustic Angiography
- First Posted Date
- 2018-06-01
- Last Posted Date
- 2022-04-01
- Lead Sponsor
- UNC Lineberger Comprehensive Cancer Center
- Target Recruit Count
- 20
- Registration Number
- NCT03544268
- Locations
- 🇺🇸
UNC Hospitals, Chapel Hill, North Carolina, United States
Contrast-Enhanced Ultrasound in Diagnosing Patients With Liver Cancer Undergoing Yttrium-90 Radioembolization
- Conditions
- Hepatocellular Carcinoma
- Interventions
- Drug: Sulfur Hexafluoride Lipid MicrospheresDevice: Dynamic Contrast-Enhanced Ultrasound ImagingDevice: Positron Emission TomographyDevice: Computed TomographyBiological: Yttrium-90 (90Y)
- First Posted Date
- 2017-10-03
- Last Posted Date
- 2019-05-16
- Lead Sponsor
- University of Southern California
- Registration Number
- NCT03300401
- Locations
- 🇺🇸
USC/Norris Comprehensive Cancer Center, Los Angeles, California, United States
Contrast-Enhanced Subharmonic Ultrasound Imaging in Improving Characterization of Adnexal Masses in Patients Undergoing Surgery
- Conditions
- Adnexal Mass
- Interventions
- Procedure: Contrast-Enhanced Subharmonic Ultrasound Imaging
- First Posted Date
- 2017-09-29
- Last Posted Date
- 2025-05-15
- Target Recruit Count
- 12
- Registration Number
- NCT03297112
- Locations
- 🇺🇸
Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania, United States
Noninvasive, Subharmonic Intra-Cardiac Pressure Measurement
- Conditions
- Cardiac CatheterizationBlood PressureHeart VentriclesEchocardiographyHeart Failure
- Interventions
- First Posted Date
- 2017-08-09
- Last Posted Date
- 2019-07-10
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 56
- Registration Number
- NCT03243942
- Locations
- 🇺🇸
Thomas Jefferson University and Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States
Contrast ICE for Myocardial Scar in VT Ablations
- Conditions
- Ventricular TachycardiaIschemic Cardiomyopathy
- Interventions
- First Posted Date
- 2017-07-11
- Last Posted Date
- 2019-06-12
- Lead Sponsor
- Weill Medical College of Cornell University
- Target Recruit Count
- 24
- Registration Number
- NCT03212326
Red Light Treatment in Peripheral Artery Disease
- Conditions
- VasodilationPeripheral Artery DiseaseClaudication, Intermittent
- Interventions
- Device: Red Light (670 nm energy)
- First Posted Date
- 2017-06-29
- Last Posted Date
- 2025-04-01
- Lead Sponsor
- University of Alabama at Birmingham
- Target Recruit Count
- 40
- Registration Number
- NCT03203239
- Locations
- 🇺🇸
Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Perflutren Protein-Type a Microspheres and Contrast-Enhanced Ultrasound in Improving Response to Radioembolization Therapy in Patients with Liver Cancer
- Conditions
- Hepatocellular Carcinoma
- Interventions
- Procedure: Yttrium-90 Microsphere RadioembolizationProcedure: Dynamic Contrast-Enhanced Ultrasound Imaging
- First Posted Date
- 2017-06-26
- Last Posted Date
- 2025-02-12
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 104
- Registration Number
- NCT03199274
- Locations
- 🇺🇸
Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania, United States
Contrast-enhanced Ultrasound for Complex Kidney Lesion Diagnosis in Patients With CKD Extension
- Conditions
- Chronic Kidney DiseasesCystic Kidney Disease
- Interventions
- First Posted Date
- 2017-06-22
- Last Posted Date
- 2021-07-21
- Lead Sponsor
- University of North Carolina, Chapel Hill
- Target Recruit Count
- 25
- Registration Number
- NCT03196076
- Locations
- 🇺🇸
University of North Carolina of Chapel hill, Chapel Hill, North Carolina, United States
Contrast-Enhanced Ultrasound in Predicting Treatment Response in Patients With Liver Cancer Receiving Transarterial Chemoembolization With Drug Eluting Beads
- Conditions
- Hepatocellular Carcinoma
- Interventions
- Device: Dynamic Contrast-Enhanced Ultrasound ImagingDevice: Contrast-enhanced Magnetic Resonance Imaging
- First Posted Date
- 2017-02-07
- Last Posted Date
- 2025-05-02
- Target Recruit Count
- 15
- Registration Number
- NCT03045497
Drug Development Updates
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