Bisoprolol

Generic Name: Bisoprolol

Brand Names: Ziac

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₃₁NO_₄

CAS Number: 66722-44-9

Unique Ingredient Identifier: Y41JS2NL6U

Background: Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure. It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as Carvedilol and Labetalol. It may be used alone or in combination with other drugs to manage hypertension and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.

Indication: Bisoprolol is indicated for the treatment of mild to moderate hypertension. It may be used off-label to treat heart failure, atrial fibrillation, and angina pectoris.

Associated Conditions: Atrial Fibrillation, Cardiovascular Events, Chronic Stable Angina Pectoris, Heart Failure, Hypertension, Mild Hypertension, Premature Ventricular Contraction (PVC), Supraventricular Arrhythmias, Moderate Hypertension, Perioperative arrhythmia

Clinical Trials

Evaluation of the Clinical Efficacy and Safety of Amlodipine 5mg/ Bisoprolol Fumarate 5mg /Perindopril Arginine 5mg Fixed-dose Combination in Capsule and Free Monotherapy at the Same Dose in Patients With Uncontrolled Essential Hypertension.

Phase 3

Completed

Conditions: Essential Hypertension

Interventions: Combination Product: Amlodipine 5mg + bisoprolol fumarate 5mg + perindopril arginine 5mg
Drug: Norvasc 5mg tablet
Drug: Concor 5mg tablet
Drug: Coversyl 5mg tablet

First Posted Date: 2022-03-21

Last Posted Date: 2022-08-05

Lead Sponsor: Servier

Target Recruit Count: 150

Registration Number: NCT05288400

Locations: 🇷🇺
Problems of Cardiovascular Diseases" 6 Sosnovy Bulvar St., Kemerovo, Russian Federation
🇷🇺
Autonomous non-profit organization "Medical Center "Alliance" 12 Molodezhnaya St., 12, Kirovsk, Russian Federation
🇷🇺
Regional state budget health care institution "Altai Regional Cardiological dispensary" 46 Malakhova St., Barnaul, Altai Region, Russian Federation

and more 12 locations

Bisoprolol Administration to Prevent Anthracycline-induced Cardiotoxicity

Phase 3

Completed

Conditions: Cardiomyopathies
Systolic Dysfunction
Chemotherapy Effect
Diastolic Dysfunction

Interventions: Drug: Placebo
Drug: Bisoprolol

First Posted Date: 2022-01-03

Last Posted Date: 2022-01-03

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Target Recruit Count: 80

Registration Number: NCT05175066

Locations: 🇮🇷
Rasool Akram hospital, Tehran, Iran, Islamic Republic of

Activation of Brown Adipose Tissue Metabolism Using Mirabegron

Not Applicable

Completed

Conditions: Type 2 Diabetes

Interventions: Drug: Mirabegron
Drug: Bisoprolol Fumarate

First Posted Date: 2021-03-30

Last Posted Date: 2024-12-09

Lead Sponsor: Université de Sherbrooke

Target Recruit Count: 9

Registration Number: NCT04823442

Locations: 🇨🇦
Centre de recherche du CHUS, Sherbrooke, Quebec, Canada

Echocardiographic Study of a Single Dose Bisoprolol Versus Nebivolol in Healthy Subjects

Phase 4

Withdrawn

Conditions: Bisoprolol Adverse Reaction
Nebivolol Adverse Reaction

Interventions: Drug: Bisoprolol versus Nebivolol

First Posted Date: 2020-06-16

Last Posted Date: 2022-12-20

Lead Sponsor: Clinical Hospital Center Zemun

Registration Number: NCT04432610

Locations: 🇷🇸
Clinical Hospital Centre Zemun, Belgrade, Serbia

Comparative Study Between the Efficacy of Verapamil and Bisoprolol on Reduction of Bleeding During Endoscopic Sinus Surgery Under General Anaesthesia.

Early Phase 1

Conditions: Heart Rate
Endoscopic Sinus Surgery
Blood Loss

Interventions: Drug: Placebo oral tablet
Drug: Verapamil
Drug: Bisoprolol

First Posted Date: 2020-04-22

Last Posted Date: 2021-12-03

Lead Sponsor: Assiut University

Target Recruit Count: 135

Registration Number: NCT04356196

Locations: 🇪🇬
Faculty of medicine Assiut university, Assiut, Egypt

Effect of Amlodipine Versus Bisoprolol on Hypertensive Patients With End-stage Renal Disease on Maintenance Hemodialysis.

Phase 4

Completed

Conditions: Hypertension, Renal

Interventions: Drug: Bisoprolol Fumarate 5-10 mg
Drug: Amlodipine 5-10 mg

First Posted Date: 2019-09-11

Last Posted Date: 2021-02-17

Lead Sponsor: Alexandria University

Target Recruit Count: 46

Registration Number: NCT04085562

Locations: 🇪🇬
El Mowassat University hospital, Alexandria, Egypt

Preventing Adverse Cardiac Events in COPD

Phase 3

Completed

Conditions: Cardiovascular Diseases
Chronic Obstructive Pulmonary Disease

Interventions: Drug: Placebo Oral Tablet
Drug: Bisoprolol

First Posted Date: 2019-04-17

Last Posted Date: 2025-05-16

Lead Sponsor: The George Institute

Target Recruit Count: 280

Registration Number: NCT03917914

Locations: 🇮🇳
Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India
🇮🇳
St John's Medical College Hospital, Bangalore, India
🇦🇺
Westmead Hospital, Sydney, New South Wales, Australia

and more 21 locations