Bisoprolol

Generic Name: Bisoprolol

Brand Names: Ziac

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₃₁NO_₄

CAS Number: 66722-44-9

Unique Ingredient Identifier: Y41JS2NL6U

Background: Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure. It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternati...

Indication: Bisoprolol is indicated for the treatment of mild to moderate hypertension. It may be used off-label to treat heart failure, atrial fibrillation, and angina pectoris.

Associated Conditions: Atrial Fibrillation, Cardiovascular Events, Chronic Stable Angina Pectoris, Heart Failure, Hypertension, Mild Hypertension, Premature Ventricular Contraction (PVC), Supraventricular Arrhythmias, Moderate Hypertension, Perioperative arrhythmia

Associated Therapies: -

Clinical Trials

Effects of Bisoprolol and Atenolol on Sympathetic Nervous Activity and Central Aortic Pressure in Patients With Essential Hypertension

Phase 4

Completed

Conditions: Untreated Essential Hypertension

Interventions: Drug: bisoprolol
Drug: atenolol

First Posted Date: 2013-01-07

Last Posted Date: 2013-01-08

Lead Sponsor: Ruijin Hospital

Target Recruit Count: 109

Registration Number: NCT01762436

Locations: 🇨🇳
State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China

Bioequivalence Study of Bisoprolol Fumarate Tablet 10 mg Under Fed Condition

Phase 1

Completed

Conditions: Fed

Interventions: Drug: Bisoprolol Fumarate Tablet 10 mg
Drug: Bisoprolol

First Posted Date: 2012-12-07

Last Posted Date: 2012-12-07

Lead Sponsor: IPCA Laboratories Ltd.

Target Recruit Count: 24

Registration Number: NCT01744873

Locations: 🇮🇳
Accutest Research Lab (I) Pvt. Ltd., Ahmedabad, Gujarat, India

Bioequivalence Study of Bisoprolol Fumarate Tablet 10 mg Under Fasting Condition

Phase 1

Completed

Conditions: Fasting

Interventions: Drug: Bisoprolol Fumarate Tablet 10 mg
Drug: Bisoprolol

First Posted Date: 2012-12-05

Last Posted Date: 2012-12-05

Lead Sponsor: IPCA Laboratories Ltd.

Target Recruit Count: 24

Registration Number: NCT01741623

Locations: 🇮🇳
Accutest Research Lab (I) Pvt. Ltd., Ahmedabad, Gujarat, India

Beta Blocker Therapy in Moderate to Severe COPD

Phase 4

Completed

Conditions: Chronic Obstructive Pulmonary Disease

Interventions: Drug: Carvedilol
Drug: Bisoprolol
Drug: Beclometasone/formoterol
Drug: Tiotropium
Drug: Beclometasone

First Posted Date: 2012-08-02

Last Posted Date: 2019-04-23

Lead Sponsor: University of Dundee

Target Recruit Count: 18

Registration Number: NCT01656005

Locations: 🇬🇧
Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom

Effect of Bisoprolol on Progression of Aortic Stenosis

Phase 4

Terminated

Conditions: Aortic Stenosis

Interventions: Drug: placebo
Drug: bisoprolol

First Posted Date: 2012-04-17

Last Posted Date: 2018-06-27

Lead Sponsor: Asan Medical Center

Target Recruit Count: 20

Registration Number: NCT01579058

Locations: 🇰🇷
Samsung Medical Center, Seoul, Korea, Republic of
🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
🇰🇷
Asan Medical Center, Seoul, Korea, Republic of

Comparison of Bisoprolol With Metoprolol Succinate Sustained-release on Heart Rate and Blood Pressure in Hypertensive Patients

Phase 4

Completed

Conditions: Hypertension

Interventions: Drug: Bisoprolol
Drug: Metoprolol

First Posted Date: 2012-01-11

Last Posted Date: 2015-05-13

Lead Sponsor: Merck KGaA, Darmstadt, Germany

Target Recruit Count: 186

Registration Number: NCT01508325

Locations: 🇨🇳
Merck Serono Investigational Site, Changsha City, China

A Study in Healthy Young Men to Look at What Drives the Cardiovascular Effects After Dosing With Mirabegron.

Phase 1

Completed

Conditions: Healthy Volunteers
Pharmacodynamics of Mirabegron

Interventions: Drug: mirabegron
Drug: Bisoprolol
Drug: propranolol
Drug: placebo

First Posted Date: 2011-01-27

Last Posted Date: 2013-07-03

Lead Sponsor: Astellas Pharma Inc

Target Recruit Count: 12

Registration Number: NCT01284868

Effects of Cardioselective β-blockers on Dynamic Hyperinflation in COPD

Not Applicable

Completed

Conditions: Chronic Obstructive Pulmonary Disease

Interventions: Drug: Bisoprolol
Drug: Placebo

First Posted Date: 2011-01-10

Last Posted Date: 2011-06-23

Lead Sponsor: Laval University

Target Recruit Count: 27

Registration Number: NCT01273298

Locations: 🇨🇦
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Québec, Quebec, Canada

A Randomized Controlled Study to Assess the Effects of Bisoprolol and Atenolol on Resting Heart Rate and Sympathetic Nervous System's Activity in Subjects With Essential Hypertension

Phase 4

Completed

Conditions: Hypertension

Interventions: Drug: Bisoprolol
Drug: Atenolol

First Posted Date: 2010-12-01

Last Posted Date: 2017-03-08

Lead Sponsor: Merck KGaA, Darmstadt, Germany

Target Recruit Count: 177

Registration Number: NCT01251146

Locations: 🇨🇳
Beijing Shi Jingshan Hospital, Beijing, China
🇨🇳
Shanghai Institute of Hypertension, Shanghai, China

Beta-blockers in i-PAH

Phase 1

Conditions: Idiopathic Pulmonary Arterial Hypertension

Interventions: Drug: Bisoprolol

First Posted Date: 2010-11-23

Last Posted Date: 2014-01-14

Lead Sponsor: Amsterdam UMC, location VUmc

Target Recruit Count: 30

Registration Number: NCT01246037

Locations: 🇳🇱
VUmc, Amsterdam, Netherlands

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