Bisoprolol

Generic Name: Bisoprolol

Brand Names: Ziac

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₃₁NO_₄

CAS Number: 66722-44-9

Unique Ingredient Identifier: Y41JS2NL6U

Background: Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure. It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternati...

Indication: Bisoprolol is indicated for the treatment of mild to moderate hypertension. It may be used off-label to treat heart failure, atrial fibrillation, and angina pectoris.

Associated Conditions: Atrial Fibrillation, Cardiovascular Events, Chronic Stable Angina Pectoris, Heart Failure, Hypertension, Mild Hypertension, Premature Ventricular Contraction (PVC), Supraventricular Arrhythmias, Moderate Hypertension, Perioperative arrhythmia

Associated Therapies: -

Clinical Trials

Comparison of Effect of cARvedilol Compared To bISoprolol on cenTral Pulse Pressure in Hypertension (ARTIST) Study

Phase 4

Conditions: Hypertension

Interventions: Drug: carvedilol
Drug: bisoprolol

First Posted Date: 2010-11-19

Last Posted Date: 2012-07-19

Lead Sponsor: Yoshio Matsui

Target Recruit Count: 200

Registration Number: NCT01243827

Locations: 🇯🇵
Iwakuni City Medical Center, Yamaguchi, Japan

A 12-week, Multicentric Study to Evaluate the Safety and Efficacy of Bisoprolol in Filipino Hypertensive Subjects With Diabetes

Phase 4

Completed

Conditions: Hypertension

Interventions: Drug: Bisoprolol

First Posted Date: 2010-08-27

Last Posted Date: 2017-01-30

Lead Sponsor: Merck KGaA, Darmstadt, Germany

Target Recruit Count: 125

Registration Number: NCT01190436

Locations: 🇵🇭
Research Site, Manila, Philippines

Association Between Genetic Polymorphism of Beta-adrenergic Receptor and Effects of Bisoprolol in Korean Heart Failure Patients.

Phase 4

Completed

Conditions: Chronic Heart Failure

First Posted Date: 2010-04-15

Last Posted Date: 2014-02-13

Lead Sponsor: Merck KGaA, Darmstadt, Germany

Target Recruit Count: 100

Registration Number: NCT01104558

Locations: 🇰🇷
The Catholic University of Korea Seoul St. Mary's Hospital, 505, Banpodong, SeoChoGu, Seoul, Korea, Republic of

An Active-controlled, Clinical Trial to Assess Central Hemodynamic Effects of Bisoprolol in Hypertensive Patients (Central Hemodynamic Assessment Measured in Patient With HypertensION [CHAMPION])

Phase 4

Completed

Conditions: Hypertension

Interventions: Drug: Bisoprolol
Drug: Atenolol

First Posted Date: 2010-03-03

Last Posted Date: 2014-02-13

Lead Sponsor: Merck KGaA, Darmstadt, Germany

Target Recruit Count: 209

Registration Number: NCT01079962

Locations: 🇰🇷
Severance Hosptial, 250, Seongsanno, Seodaemungu, Seoul, Korea, Republic of

Phase 4 Study to Assess the Effect of Bisoprolol on Glycemic Level in Type II Diabetic Subjects With Suboptimal Blood Pressure Control

Phase 4

Completed

Conditions: Hypertension
Diabetes Mellitus, Type II

Interventions: Drug: Bisoprolol

First Posted Date: 2010-02-10

Last Posted Date: 2014-07-04

Lead Sponsor: Merck KGaA, Darmstadt, Germany

Target Recruit Count: 202

Registration Number: NCT01066039

Locations: 🇰🇷
Seoul St. Mary´s Hospital, Seoul, Korea, Republic of

Treating Clozapine-induced Sinustachycardia With Bisoprolol

Not Applicable

Completed

Conditions: Clozapine-induced Sinustachycardia

Interventions: Drug: Bisoprolol
Drug: Placebo

First Posted Date: 2009-04-17

Last Posted Date: 2017-01-09

Lead Sponsor: University of Aarhus

Target Recruit Count: 21

Registration Number: NCT00882856

Locations: 🇩🇰
Aalborg University Hospital, Psychiatry, Aalborg, Denmark

Bisoprolol in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease

Phase 2

Terminated

Conditions: Chronic Obstructive Pulmonary Disease
Heart Failure

Interventions: Drug: Placebo
Drug: Bisoprolol

First Posted Date: 2008-06-20

Last Posted Date: 2008-09-03

Lead Sponsor: NHS Greater Glasgow and Clyde

Target Recruit Count: 27

Registration Number: NCT00702156

Locations: 🇬🇧
Cardiopulmonary Transplant Unit Glasgow Royal Infirmary, Glasgow, Scotland, United Kingdom

Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure

Phase 4

Completed

Conditions: Chronic Heart Failure

Interventions: Drug: carvedilol
Drug: bisoprolol
Drug: Nebivolol

First Posted Date: 2007-08-17

Last Posted Date: 2010-09-16

Lead Sponsor: Centro Cardiologico Monzino

Target Recruit Count: 60

Registration Number: NCT00517725

Locations: 🇮🇹
Centro Cardiologico Monzino, University of Milan, Milan, Italy

Evaluation of Heart Failure Treatment Guided by N-terminal Pro B-type Natriuretic Peptide (NTproBNP) vs Clinical Symptoms and Signs Alone

Phase 4

Completed

Conditions: Heart Failure
Ventricular Dysfunction, Left

Interventions: Drug: Captopril
Drug: Enalapril
Drug: Lisinopril
Drug: Ramipril
Drug: Trandolapril
Drug: Bisoprolol
Drug: Carvedilol
Drug: Metoprolol succinate
Drug: Candesartan
Drug: Valsartan
Drug: Eplerenone
Drug: Spironolactone
Drug: Diuretics
Drug: HF treatment according to Swedish guidelines
Procedure: Blood samples
Procedure: The Kansas City Cardiomyopathy Questionnaire (KCCQ)

First Posted Date: 2006-10-25

Last Posted Date: 2012-06-25

Lead Sponsor: AstraZeneca

Target Recruit Count: 252

Registration Number: NCT00391846

Locations: 🇸🇪
Research Site, Vaxjo, Sweden

Study to Investigate Effects of Antiischemic Drug Therapy in Silent Ischemia

Not Applicable

Completed

Conditions: Myocardial Ischemia

First Posted Date: 2006-09-29

Last Posted Date: 2006-10-12

Lead Sponsor: Luzerner Kantonsspital

Registration Number: NCT00382421

Locations: 🇨🇭
Department of Cardiology, Hospital Lucerne, Lucerne, Switzerland

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