Bisoprolol
- Generic Name
- Bisoprolol
- Brand Names
- Ziac
- Drug Type
- Small Molecule
- Chemical Formula
- C18H31NO4
- CAS Number
- 66722-44-9
- Unique Ingredient Identifier
- Y41JS2NL6U
- Background
Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure. It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as Carvedilol and Labetalol. It may be used alone or in combination with other drugs to manage hypertension and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.
- Indication
Bisoprolol is indicated for the treatment of mild to moderate hypertension. It may be used off-label to treat heart failure, atrial fibrillation, and angina pectoris.
- Associated Conditions
- Atrial Fibrillation, Cardiovascular Events, Chronic Stable Angina Pectoris, Heart Failure, Hypertension, Mild Hypertension, Premature Ventricular Contraction (PVC), Supraventricular Arrhythmias, Moderate Hypertension, Perioperative arrhythmia
A Randomized Controlled Study to Assess the Effects of Bisoprolol and Atenolol on Resting Heart Rate and Sympathetic Nervous System's Activity in Subjects With Essential Hypertension
- First Posted Date
- 2010-12-01
- Last Posted Date
- 2017-03-08
- Lead Sponsor
- Merck KGaA, Darmstadt, Germany
- Target Recruit Count
- 177
- Registration Number
- NCT01251146
- Locations
- 🇨🇳
Beijing Shi Jingshan Hospital, Beijing, China
🇨🇳Shanghai Institute of Hypertension, Shanghai, China
Beta-blockers in i-PAH
- First Posted Date
- 2010-11-23
- Last Posted Date
- 2014-01-14
- Lead Sponsor
- Amsterdam UMC, location VUmc
- Target Recruit Count
- 30
- Registration Number
- NCT01246037
- Locations
- 🇳🇱
VUmc, Amsterdam, Netherlands
Comparison of Effect of cARvedilol Compared To bISoprolol on cenTral Pulse Pressure in Hypertension (ARTIST) Study
- First Posted Date
- 2010-11-19
- Last Posted Date
- 2012-07-19
- Lead Sponsor
- Yoshio Matsui
- Target Recruit Count
- 200
- Registration Number
- NCT01243827
- Locations
- 🇯🇵
Iwakuni City Medical Center, Yamaguchi, Japan
A 12-week, Multicentric Study to Evaluate the Safety and Efficacy of Bisoprolol in Filipino Hypertensive Subjects With Diabetes
- First Posted Date
- 2010-08-27
- Last Posted Date
- 2017-01-30
- Lead Sponsor
- Merck KGaA, Darmstadt, Germany
- Target Recruit Count
- 125
- Registration Number
- NCT01190436
- Locations
- 🇵🇭
Research Site, Manila, Philippines
Comparison of Vascular Remodeling Between Different Antianginal Medication Evaluated by Noninvasive ECG-gated Fundus Photographic Evaluation
- Conditions
- Stable Angina
- Interventions
- First Posted Date
- 2010-07-15
- Last Posted Date
- 2013-12-17
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 150
- Registration Number
- NCT01162902
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Bisoprolol in Hypertension: Effect on Concomitant Elevated Heart Rate
- Conditions
- Hypertension
- First Posted Date
- 2010-04-22
- Last Posted Date
- 2014-07-31
- Lead Sponsor
- Merck KGaA, Darmstadt, Germany
- Target Recruit Count
- 351
- Registration Number
- NCT01109043
- Locations
- 🇦🇹
Merck Serono Research Site, Vienna, Austria
Association Between Genetic Polymorphism of Beta-adrenergic Receptor and Effects of Bisoprolol in Korean Heart Failure Patients.
- Conditions
- Chronic Heart Failure
- First Posted Date
- 2010-04-15
- Last Posted Date
- 2014-02-13
- Lead Sponsor
- Merck KGaA, Darmstadt, Germany
- Target Recruit Count
- 100
- Registration Number
- NCT01104558
- Locations
- 🇰🇷
The Catholic University of Korea Seoul St. Mary's Hospital, 505, Banpodong, SeoChoGu, Seoul, Korea, Republic of
An Active-controlled, Clinical Trial to Assess Central Hemodynamic Effects of Bisoprolol in Hypertensive Patients (Central Hemodynamic Assessment Measured in Patient With HypertensION [CHAMPION])
- First Posted Date
- 2010-03-03
- Last Posted Date
- 2014-02-13
- Lead Sponsor
- Merck KGaA, Darmstadt, Germany
- Target Recruit Count
- 209
- Registration Number
- NCT01079962
- Locations
- 🇰🇷
Severance Hosptial, 250, Seongsanno, Seodaemungu, Seoul, Korea, Republic of
A Prospective, Open-labeled, Multi-centric Trial in Subjects With Systolic Heart Failure to Evaluate Bisoprolol Treatment for the Effects on Surrogate Markers of Heart Failure in Korea
- Conditions
- Heart Failure, Congestive
- Interventions
- First Posted Date
- 2010-02-24
- Last Posted Date
- 2014-02-14
- Lead Sponsor
- Merck KGaA, Darmstadt, Germany
- Target Recruit Count
- 180
- Registration Number
- NCT01074307
- Locations
- 🇰🇷
Konkuk University Medical Center, Seoul, Korea, Republic of
Phase 4 Study to Assess the Effect of Bisoprolol on Glycemic Level in Type II Diabetic Subjects With Suboptimal Blood Pressure Control
- First Posted Date
- 2010-02-10
- Last Posted Date
- 2014-07-04
- Lead Sponsor
- Merck KGaA, Darmstadt, Germany
- Target Recruit Count
- 202
- Registration Number
- NCT01066039
- Locations
- 🇰🇷
Seoul St. Mary´s Hospital, Seoul, Korea, Republic of
Drug Development Updates
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