Vitamin K1
- Generic Name
- Vitamin K1
- Brand Names
- Aquamephyton, Infuvite, Infuvite Pediatric, Mephyton, Mvi Pediatric, Phytonadione
- Drug Type
- Small Molecule
- Chemical Formula
- C31H46O2
- CAS Number
- 84-80-0
- Unique Ingredient Identifier
- S5Z3U87QHF
- Background
Vitamin K1, also called phylloquinone or phytonadione, is a fat soluble vitamin. Phylloquinone is a cofactor of the enzyme γ-carboxylase, which modifies and activates precursors to coagulation factors II, VII, IX, and X. It is indicated in the treatment of coagulation disorders due to faulty formation of coagulation factors II, VII, IX, and X caused by defic...
- Indication
Oral phylloquinone is indicated to treat prothrombin deficiency caused by coumarin or indanedione derivatives; and hypoprothrombinemia secondary to antibacterial therapy, salicylates, or obstructive jaundice or biliary fistulas with concomitant bile salt administration.
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- Associated Conditions
- Coagulation Disorder, Hypoprothrombinemia, Hemorrhagic disease of the newborn
- Associated Therapies
- Vitamin supplementation
Prevention of Cefoperazone-induced Coagulopathy
- First Posted Date
- 2023-02-23
- Last Posted Date
- 2023-10-10
- Lead Sponsor
- Helwan University
- Target Recruit Count
- 56
- Registration Number
- NCT05742295
- Locations
- 🇪🇬
6-October Hospital, Giza, Egypt
Better Evidence and Translation for Calciphylaxis
- First Posted Date
- 2021-08-24
- Last Posted Date
- 2024-06-21
- Lead Sponsor
- University of Sydney
- Target Recruit Count
- 350
- Registration Number
- NCT05018221
- Locations
- 🇦🇺
Princess Alexandra Hospital, Brisbane, Queensland, Australia
🇦🇺Sunshine Hospital (Western Health), St Albans, Victoria, Australia
🇳🇿Tauranga Hospital, Tauranga, New Zealand
Comparative Study Evaluating the Effect of Vitamin K1 Versus Vitamin K2 on Vascular Calcification in Dialysis Patients
- Conditions
- Interventions
- First Posted Date
- 2020-07-20
- Last Posted Date
- 2021-07-21
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 40
- Registration Number
- NCT04477811
- Locations
- 🇪🇬
Ainshams University, Cairo, Egypt
Effects of Fhytomenadione on Coronary Artery Calcification of Hemodialysis Patients
- Conditions
- Interventions
- First Posted Date
- 2020-01-29
- Last Posted Date
- 2020-01-29
- Lead Sponsor
- Instituto Mexicano del Seguro Social
- Target Recruit Count
- 60
- Registration Number
- NCT04247087
- Locations
- 🇲🇽
Hospital de Alta Especialidad No. 1 Bajío, Boulevard Adolfo López Mateos esquina Insurgentes S/N, colonia Los Paraísos, Leon, Guanajuato, Mexico
Comparison of Vitamin K Doses in Patients With Larger Burn Injuries
- First Posted Date
- 2019-05-08
- Last Posted Date
- 2021-08-25
- Lead Sponsor
- Joseph M. Still Research Foundation, Inc.
- Target Recruit Count
- 50
- Registration Number
- NCT03941535
- Locations
- 🇺🇸
Joseph M. Still Burn Center at Doctors Hospital, Augusta, Georgia, United States
Effect of Vitamin K in Critically Ill Patients
- Conditions
- Interventions
- First Posted Date
- 2018-12-20
- Last Posted Date
- 2021-03-18
- Lead Sponsor
- Region Skane
- Target Recruit Count
- 52
- Registration Number
- NCT03782025
- Locations
- 🇸🇪
Skåne University Hospital, Lund, Skåne, Sweden
🇸🇪Intensive and perioperative care. Skåne University Hospital. Lund, Lund, Skåne, Sweden
Vitamin K1 in the Treatment of Spontaneous Intracerebral Hemorrhage
- Conditions
- Interventions
- First Posted Date
- 2018-01-03
- Last Posted Date
- 2018-01-04
- Lead Sponsor
- HUANG XIANJIAN
- Target Recruit Count
- 400
- Registration Number
- NCT03388970
- Locations
- 🇨🇳
The fifth people's hospital of Longgang District, Shenzhen, Shenzhen, Guangdong, China
🇨🇳Baoan District central hospital of Shenzhen, Shenzhen, Guangdong, China
🇨🇳Shajing hospital of Baoan District ,Shenzhen, Shenzhen, Guangdong, China
Pharmacokinetic Drug-Drug Interaction Study of Rucaparib
- Conditions
- Interventions
- First Posted Date
- 2016-04-15
- Last Posted Date
- 2023-06-09
- Lead Sponsor
- pharmaand GmbH
- Target Recruit Count
- 17
- Registration Number
- NCT02740712
- Locations
- 🇵🇱
BioVirtus Research Site, Kajetany, Mokra 7, Poland
🇵🇱Zachodniopomorskie Centrum Onkologii Centrum Innowacji, Szczecin, Poland
🇵🇱Med Polonia, Poznan, Poland
Vitamin K Supplementation in Patients on Hemodialysis
- Conditions
- Interventions
- First Posted Date
- 2014-12-24
- Last Posted Date
- 2018-02-06
- Lead Sponsor
- University Health Network, Toronto
- Target Recruit Count
- 3
- Registration Number
- NCT02324686
- Locations
- 🇨🇦
University Health Network, Toronto, Ontario, Canada
Study to Evaluate the Effect of Multiple Doses of BIRT 2584 XX Tablets on the Pharmacokinetic Parameters of Warfarin, Omeprazole, Caffeine, and Dextromethorphan in Healthy Male Volunteers
- Conditions
- Interventions
- First Posted Date
- 2014-10-06
- Last Posted Date
- 2014-10-06
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 20
- Registration Number
- NCT02256813
Drug Development Updates
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