Sodium Thiosulfate

Generic Name: Sodium Thiosulfate

Indication: ⑴治疗氰化物中毒，与高铁血红蛋白形成剂联合应用；

⑵治疗降压药硝普钠过量中毒；

⑶治疗可溶性钡盐（如硝酸钡）中毒；

⑷治疗砷、汞、铋、铅等金属中毒，但首选二巯基类药物及依地酸类药物；

⑸作为非特异性抗炎药，用于皮炎、湿疹、荨麻疹、药物性皮炎、副银屑病的治疗【1.《糖皮质激素类药物临床应用指导原则》；2.《中西医结合系统药物治疗湿疹皮炎类皮肤病专家共识》2015；3.《临床诊疗指南皮肤病与性病分册》】。

Clinical Trials

Evaluation of Thiosulfate Enhanced Organ Preservation Solution in Kidney Transplantation

Not Applicable

Not yet recruiting

Conditions: Renal Transplant
Kidney Transplant

Interventions: Drug: Sodium Thiosulfate

First Posted Date: 2024-03-01

Last Posted Date: 2024-03-01

Lead Sponsor: Alp Sener

Target Recruit Count: 120

Registration Number: NCT06288152

Sodium Thiosulfate Otoprotection During Salvage Cisplatin Therapy

Early Phase 1

Recruiting

Conditions: Ototoxicity, Drug-Induced

Interventions: Drug: Sodium Thiosulfate

First Posted Date: 2023-03-06

Last Posted Date: 2024-01-18

Lead Sponsor: Children's Hospital Medical Center, Cincinnati

Target Recruit Count: 33

Registration Number: NCT05756660

Locations: 🇺🇸
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

Phase 3

Recruiting

Conditions: Childhood Medulloblastoma

Interventions: Procedure: Audiometric Test
Procedure: Auditory Brainstem Response
Procedure: Biospecimen Collection
Drug: Cisplatin
Drug: Cyclophosphamide
Drug: Lomustine
Procedure: Magnetic Resonance Imaging
Other: Quality-of-Life Assessment
Radiation: Radiation Therapy
Drug: Sodium Thiosulfate
Other: Survey Administration
Drug: Vincristine

First Posted Date: 2022-05-19

Last Posted Date: 2025-05-04

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 225

Registration Number: NCT05382338

Locations: 🇺🇸
Children's Hospital of Alabama, Birmingham, Alabama, United States
🇺🇸
Phoenix Childrens Hospital, Phoenix, Arizona, United States
🇺🇸
Arkansas Children's Hospital, Little Rock, Arkansas, United States

and more 70 locations

Better Evidence and Translation for Calciphylaxis

Phase 3

Recruiting

Conditions: Calciphylaxis

Interventions: Drug: Sodium Thiosulfate
Device: Medium Cut-off Dialyser
Device: High Flux Dialyser
Drug: Vitamin K1
Drug: Magnesium citrate
Drug: Placebo capsule (Vitamin K1)
Drug: Placebo injection (normal saline)
Drug: Placebo tablet (Magnesium citrate)

First Posted Date: 2021-08-24

Last Posted Date: 2024-06-21

Lead Sponsor: University of Sydney

Target Recruit Count: 350

Registration Number: NCT05018221

Locations: 🇦🇺
Princess Alexandra Hospital, Brisbane, Queensland, Australia
🇦🇺
Sunshine Hospital (Western Health), St Albans, Victoria, Australia
🇳🇿
Tauranga Hospital, Tauranga, New Zealand

and more 11 locations

Individualized Response Assessment to Heated Intraperitoneal Chemotherapy (HIPEC) for the Treatment of Peritoneal Carcinomatosis From Ovarian, Colorectal, Appendiceal, or Peritoneal Mesothelioma Histologies

Phase 1

Recruiting

Conditions: Peritoneal Mesothelioma
Ovarian Cancer
Gastrointestinal Cancer
Appendiceal Cancer
Peritoneal Carcinomatosis

Interventions: Procedure: Heated Intraperitonial Chemotherapy
Drug: Mitomycin C
Drug: Cisplatin
Drug: Oxaliplatin
Drug: 5-Fluorouracil
Drug: Doxorubicin
Drug: Sodium Thiosulfate

First Posted Date: 2021-04-15

Last Posted Date: 2025-05-01

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 60

Registration Number: NCT04847063

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin

Phase 2

Completed

Conditions: Locally Advanced Laryngeal Squamous Cell Carcinoma
Locally Advanced Oral Cavity Squamous Cell Carcinoma
Pathologic Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Stage III Lip and Oral Cavity Cancer AJCC v8
Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Stage IVA Lip and Oral Cavity Cancer AJCC v8
Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Locally Advanced Hypopharyngeal Squamous Cell Carcinoma
Stage III Laryngeal Cancer AJCC v8
Stage IV Hypopharyngeal Carcinoma AJCC v8

Interventions: Drug: Cisplatin
Other: Hearing Handicap Inventory for Adults - Screening
Radiation: Radiation Therapy
Drug: Sodium Thiosulfate

First Posted Date: 2020-09-09

Last Posted Date: 2024-06-28

Lead Sponsor: Hyunseok Kang, MD

Target Recruit Count: 16

Registration Number: NCT04541355

Locations: 🇺🇸
University of California, San Francisco, San Francisco, California, United States

A Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT Strategy

Phase 3

Recruiting

Conditions: Hepatoblastoma

Interventions: Procedure: Primary surgery resection
Drug: Sodium Thiosulfate Injection
Drug: mono CDDP-Group A2
Procedure: Biopsy
Drug: Cisplatin, 5-Fluorouracil, Vincristine, Doxorubicin-Group C
Procedure: Resection or transplant
Procedure: Resection of pulmonary nodules
Drug: mono CDDP- Group B
Drug: Block 1 to 3 (Cisplatin, Doxorubicin) Group D
Drug: Consolidation (Carboplatin, Doxorubicin) -Group D1
Drug: Consolidation (Carboplatin +Doxorubicin/Vincristine + Irinotecan)-Group D2

First Posted Date: 2020-07-20

Last Posted Date: 2025-05-18

Lead Sponsor: Shanghai Children's Medical Center

Target Recruit Count: 330

Registration Number: NCT04478292

Locations: 🇨🇳
Shanghai Children's Medical Center, Shanghai, Shanghai, China

Study to Evaluate Safety and Efficacy of DB-020 to Protect Hearing in Patients Receiving Cisplatin for Cancer Treatment

Phase 1

Completed

Conditions: Ototoxicity

Interventions: Drug: DB-020
Drug: Placebo

First Posted Date: 2020-02-10

Last Posted Date: 2023-07-06

Lead Sponsor: Decibel Therapeutics

Target Recruit Count: 22

Registration Number: NCT04262336

Locations: 🇺🇸
Northwell Health Cancer Center, Lake Success, New York, United States
🇦🇺
Oncology and Palliative Care Research, Melbourne, Victoria, Australia
🇺🇸
WVU Cancer Institute, Morgantown, West Virginia, United States

and more 5 locations

Efficacy of Sodium Thiosulfate in Shoulder Pain in Calcific Tendinitis of the Rotator Cuff

Phase 2

Conditions: Sodium Thiosulfate
Calcific Tendinitis
Shoulder Pain

Interventions: Drug: Sodium Thiosulfate

First Posted Date: 2020-02-05

Last Posted Date: 2021-09-28

Lead Sponsor: Soraia Azevedo

Target Recruit Count: 80

Registration Number: NCT04251832

Locations: 🇵🇹
Unidade Local de Saúde do Alto Minho - Hospital Conde de Bertiandos, Ponte de Lima, Portugal

Heated Intra-peritoneal Chemotherapy with Doxorubicin and Cisplatin for Abdominal for Pelvic Tumors in Pediatric Patients

Early Phase 1

Terminated

Conditions: Malignant Pelvic Neoplasm
Recurrent Gastric Carcinoma
Recurrent Liposarcoma
Recurrent Ovarian Carcinoma
Recurrent Rhabdomyosarcoma
Refractory Colon Carcinoma
Malignant Abdominal Neoplasm
Refractory Ovarian Carcinoma
Recurrent Colon Carcinoma
Recurrent Desmoplastic Small Round Cell Tumor

Interventions: Drug: Cisplatin
Procedure: Cytoreductive Surgery
Drug: Doxorubicin
Drug: Hyperthermic Intraperitoneal Chemotherapy
Drug: Sodium Thiosulfate
Procedure: Computed Tomography
Procedure: Magnetic Resonance Imaging
Procedure: Positron Emission Tomography
Procedure: Biospecimen Collection

First Posted Date: 2019-12-30

Last Posted Date: 2025-02-20

Lead Sponsor: Mayo Clinic

Target Recruit Count: 2

Registration Number: NCT04213794

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

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