Pilocarpine
- Generic Name
- Pilocarpine
- Brand Names
- Betoptic Pilo, Isoptocarpine, Minims Pilocarpine Nitrate, Salagen, Vuity
- Drug Type
- Small Molecule
- Chemical Formula
- C11H16N2O2
- CAS Number
- 92-13-7
- Unique Ingredient Identifier
- 01MI4Q9DI3
- Background
Pilocarpine is a cholinergic muscarinic receptor agonist.
- Indication
Pilocarpine oral tablets are indicated for the treatment of dry mouth caused by Sjogren's Syndrome or radiotherapy for cancer of the head and neck.
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- Associated Conditions
- Acute angle-closure glaucoma, Dry Mouth, Glaucoma, Closed-Angle, Increased Intra Ocular Pressure (IOP), Narrow-angle glaucoma, Ocular Hypertension, Open Angle Glaucoma (OAG), Presbyopia, Chronic open-angle glaucoma
- Associated Therapies
- -
Laser Peripheral Iridotomy Plus Laser Peripheral Iridoplasty for Primary Angle Closure
- Conditions
- Interventions
- First Posted Date
- 2015-11-24
- Last Posted Date
- 2018-09-06
- Lead Sponsor
- Sun Yat-sen University
- Target Recruit Count
- 240
- Registration Number
- NCT02613013
- Locations
- 🇨🇳
Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China
A Study to Investigate the Effect of Oral Doses of Pilocarpine on Salivary Secretion and Static Pupillometry in Healthy Subjects
- First Posted Date
- 2015-05-18
- Last Posted Date
- 2015-08-13
- Lead Sponsor
- Astellas Pharma Europe B.V.
- Target Recruit Count
- 12
- Registration Number
- NCT02447315
- Locations
- 🇬🇧
PAREXEL Early Phase Clinical Unit, Harrow, United Kingdom
First-in-human: Single Ascending Dose, Food Effect, Drug-drug Interaction, Multiple Ascending Dose, Proof of Pharmacology
- Conditions
- Interventions
- First Posted Date
- 2015-04-20
- Last Posted Date
- 2016-07-01
- Lead Sponsor
- Astellas Pharma Europe B.V.
- Target Recruit Count
- 116
- Registration Number
- NCT02420782
- Locations
- 🇬🇧
Site GB44001, Harrow, United Kingdom
🇩🇪Site DE49001, Berlin, Germany
Efficacy of Cevimeline Versus Pilocarpine in the Secretion of Saliva
- First Posted Date
- 2012-09-21
- Last Posted Date
- 2018-06-04
- Lead Sponsor
- University of Kentucky
- Target Recruit Count
- 15
- Registration Number
- NCT01690052
- Locations
- 🇺🇸
University of Kentucky Orofacial Pain Center College of Dentistry, Lexington, Kentucky, United States
Effect of 0.1% Pilocarpine Mouthwash on Xerostomia
- First Posted Date
- 2012-06-26
- Last Posted Date
- 2012-06-26
- Lead Sponsor
- Jeong-seong Kwon
- Target Recruit Count
- 60
- Registration Number
- NCT01627626
- Locations
- 🇰🇷
Yonsei University Dental Hospital, Seoul, Korea, Republic of
Effects of Novel Combinations of Tolterodine/Pilocarpine on Pharmacokinetics (PK) and Pharmacodynamics (PD) of Tolterodine in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2009-12-21
- Last Posted Date
- 2015-12-30
- Lead Sponsor
- TheraVida, Inc.
- Target Recruit Count
- 18
- Registration Number
- NCT01036035
Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer
- Conditions
- Interventions
- First Posted Date
- 2008-04-11
- Last Posted Date
- 2019-11-19
- Lead Sponsor
- Radiation Therapy Oncology Group
- Target Recruit Count
- 196
- Registration Number
- NCT00656513
- Locations
- 🇺🇸
Schiffler Cancer Center at Wheeling Hospital, Wheeling, West Virginia, United States
🇨🇦McGill Cancer Centre at McGill University, Montreal, Quebec, Canada
🇺🇸Hospital of Saint Raphael, New Haven, Connecticut, United States
Bioequivalency Study of 7.5 mg Pilocarpine Under Fed Conditions
- Conditions
- First Posted Date
- 2008-02-18
- Last Posted Date
- 2018-01-23
- Lead Sponsor
- Roxane Laboratories
- Target Recruit Count
- 28
- Registration Number
- NCT00618059
- Locations
- 🇺🇸
CEDRA Clinical Research, LLC, Austin, Texas, United States
Bioequivalency Study of 7.5 mg Pilocarpine Tablets Under Fasting Conditions
- Conditions
- First Posted Date
- 2008-01-28
- Last Posted Date
- 2018-01-23
- Lead Sponsor
- Roxane Laboratories
- Target Recruit Count
- 28
- Registration Number
- NCT00602524
- Locations
- 🇺🇸
CEDRA Clinical Research, LLC, Austin, Texas, United States
Bioequivalency Study of 5 mg Piolocarpine Tablets Under Fed Conditions
- Conditions
- First Posted Date
- 2008-01-28
- Last Posted Date
- 2018-01-23
- Lead Sponsor
- Roxane Laboratories
- Target Recruit Count
- 28
- Registration Number
- NCT00601211
- Locations
- 🇺🇸
CEDRA Clinical Research, LLC, Austin, Texas, United States
Drug Development Updates
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