Loperamide
- Generic Name
- Loperamide
- Brand Names
- Diamode, Imodium, Imodium Multi-symptom Relief
- Drug Type
- Small Molecule
- Chemical Formula
- C29H33ClN2O2
- CAS Number
- 53179-11-6
- Unique Ingredient Identifier
- 6X9OC3H4II
- Background
Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as diphenoxylate and haloperidol. Due to pharmacologic...
- Indication
Loperamide is indicated for the relief of diarrhea, including Travelers’ Diarrhea. As an off-label use, it is often used to manage chemotherapy-related diarrhea.
- Associated Conditions
- Diarrhea, Traveler's Diarrhea
- Associated Therapies
- -
ADAM-Afatinib Diarrhea Assessment and Management
- First Posted Date
- 2013-03-20
- Last Posted Date
- 2016-10-31
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 40
- Registration Number
- NCT01814553
- Locations
- 🇺🇸
1200.167.01001 Boehringer Ingelheim Investigational Site, Morristown, New Jersey, United States
🇺🇸1200.167.01009 Boehringer Ingelheim Investigational Site, Santa Rosa, California, United States
🇺🇸1200.167.01020 Boehringer Ingelheim Investigational Site, Orlando, Florida, United States
Effects of Methylnaltrexone in Comparison to Naloxone on Loperamide-induced Delay of the Oro-cecal, Whole-gut and Colon Transit Time.
- First Posted Date
- 2012-05-11
- Last Posted Date
- 2012-05-11
- Lead Sponsor
- University Medicine Greifswald
- Target Recruit Count
- 16
- Registration Number
- NCT01596764
- Locations
- 🇩🇪
Department of Clinical Pharmacology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany
Effects of 500 mg Immediate Release and Extended Release Methylnaltrexone on Loperamide-induced Delay of the Oro-cecal and Whole-gut Transit Time in Healthy Subjects
- First Posted Date
- 2012-05-11
- Last Posted Date
- 2016-10-26
- Lead Sponsor
- University Medicine Greifswald
- Target Recruit Count
- 15
- Registration Number
- NCT01596777
- Locations
- 🇩🇪
Department of Clinical Pharmacology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany
Acupuncture for Patients With Diarrhea-predominant IBS or Functional Diarrhea: a Randomized Controlled Trial
- Conditions
- Interventions
- First Posted Date
- 2011-05-10
- Last Posted Date
- 2015-04-10
- Target Recruit Count
- 449
- Registration Number
- NCT01350570
- Locations
- 🇨🇳
First affiliated hospital of Chengdu university of TCM, Chengdu, Sichuan, China
Efficacy and Mechanisms of Pharmacologic Treatment of Fecal Incontinence
- First Posted Date
- 2008-08-04
- Last Posted Date
- 2015-04-01
- Lead Sponsor
- US Department of Veterans Affairs
- Target Recruit Count
- 80
- Registration Number
- NCT00727649
- Locations
- 🇺🇸
VA Medical Center, Birmingham, Birmingham, Alabama, United States
A Study to Determine Effective Prophylaxis and Treatment of Nelfinavir-Associated Diarrhea
- Conditions
- Interventions
- First Posted Date
- 2008-04-02
- Last Posted Date
- 2011-06-08
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 17
- Registration Number
- NCT00650637
- Locations
- 🇺🇸
Pfizer Investigational Site, Houston, Texas, United States
Efficacy of Loperamide for C. Difficile Colitis and Other Diarrheal Diseases Associated With Antibiotic Therapy
- Conditions
- Interventions
- First Posted Date
- 2008-01-11
- Last Posted Date
- 2016-05-03
- Lead Sponsor
- Michael E. DeBakey VA Medical Center
- Target Recruit Count
- 120
- Registration Number
- NCT00591357
- Locations
- 🇺🇸
VAMC, Houston, Texas, United States
Azithromycin, With or Without Loperamide, to Treat Travelers' Diarrhea
- Conditions
- Interventions
- First Posted Date
- 2006-08-03
- Last Posted Date
- 2015-06-19
- Target Recruit Count
- 176
- Registration Number
- NCT00359970
- Locations
- 🇲🇽
University of Texas Enteric Disease Research Clinics, Guadalajara, Jalisco, Mexico
Octreotide Compared With Loperamide Hydrochloride for Chemotherapy-Related Diarrhea in Patients With Colorectal Cancer
- Conditions
- First Posted Date
- 2004-07-19
- Last Posted Date
- 2023-06-18
- Lead Sponsor
- Eastern Cooperative Oncology Group
- Target Recruit Count
- 500
- Registration Number
- NCT00003057
- Locations
- 🇺🇸
CCOP - Christiana Care Health Services, Wilmington, Delaware, United States
🇺🇸CCOP - Mount Sinai Medical Center, Miami Beach, Florida, United States
🇺🇸University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States
Drug Development Updates
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