A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha (TNF-a) and other cytokine action. Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enrol in the THALIDOMID Risk Evaluation and Mitigation Strategy (REMS) program to ensure contraception adherence.
Thalidomide is primarily used for the acute treatment and maintenance therapy to prevent and suppress the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL).
UNC Chapel Hill, Chapel Hill, North Carolina, United States
M D Anderson Cancer Center, Houston, Texas, United States
Cancer Research UK and University College London Cancer Trials Centre, Exeter, England, United Kingdom
Mayo Clinic, Rochester, Minnesota, United States
Ankara Numune Education and Research Hospital,Hematology Department, Ankara, Turkey
Baskent University School of Medicine Education and Research Hospital, Hematology Department, Adana, Turkey
Gazi University School of Medicine, Hematology Department, Ankara, Turkey
Liver Cancer Institute, Shanghai, Shanghai, China
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
Hospital de Valme, Sevilla, Spain
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