Naloxone
- Generic Name
- Naloxone
- Brand Names
- Kloxxado, Narcan, Suboxone, Targin, Targiniq, Zimhi, Zubsolv, Nyxoid
- Drug Type
- Small Molecule
- Chemical Formula
- C19H21NO4
- CAS Number
- 465-65-6
- Unique Ingredient Identifier
- 36B82AMQ7N
- Background
Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, causing the rapid removal of any other d...
- Indication
Naloxone nasal sprays are indicated for the reversal of an opioid overdose or suspected opioid overdose: it is intended for immediate administration as emergency therapy in settings where opioids may be present. Intramuscular, intravenous, and subcutaneous injections are indicated for complete or partial reversal of opioid depression, diagnosis of known or s...
- Associated Conditions
- Opioid Dependence, Opioid Overdose, Pruritus, Respiratory Depression, Septic Shock, Severe Pain, Moderate Pain, Suspected Opioid Overdose
- Associated Therapies
- Emergency Care
Efficacy of Spinal Manipulation Therapy or Mindfulness-based Reduction Therapy on Patients With Chronic Low Back Pain
- Conditions
- Interventions
- First Posted Date
- 2021-02-09
- Last Posted Date
- 2024-10-08
- Lead Sponsor
- Rush University Medical Center
- Target Recruit Count
- 140
- Registration Number
- NCT04744883
- Locations
- 🇺🇸
Rush University Medical Center, Chicago, Illinois, United States
🇺🇸Vanderbilt University Medical Center, Nashville, Tennessee, United States
Effect of Intrathecal Naloxone in the Incidence of Pruritis After C.S
- First Posted Date
- 2020-08-19
- Last Posted Date
- 2021-03-26
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 96
- Registration Number
- NCT04518618
- Locations
- 🇪🇬
Faculty of Medicine, Tanta, Algharbia, Egypt
🇪🇬Tanta University hospitals, Tanta, Egypt
Chronic Low Back Pain and Meditation
- Conditions
- Interventions
- First Posted Date
- 2019-07-26
- Last Posted Date
- 2023-10-11
- Lead Sponsor
- University of California, San Diego
- Target Recruit Count
- 88
- Registration Number
- NCT04034004
- Locations
- 🇺🇸
UC San Diego Center for Mindfulness, San Diego, California, United States
🇺🇸Altman Clinical and Translational Research Institute, La Jolla, California, United States
Neural Correlates of Hypoalgesia Driven by Observation
- First Posted Date
- 2019-04-01
- Last Posted Date
- 2024-06-27
- Lead Sponsor
- University of Maryland, Baltimore
- Target Recruit Count
- 182
- Registration Number
- NCT03897998
- Locations
- 🇺🇸
University of Maryland, Baltimore, Maryland, United States
Evaluation of Intranasal Naltrexone and Naloxone
- Conditions
- Interventions
- First Posted Date
- 2019-02-22
- Last Posted Date
- 2020-09-14
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Target Recruit Count
- 12
- Registration Number
- NCT03851731
Treatment of Chronic Itch in Patients Under Arsenic Exposure With Sublingual Naloxone
- First Posted Date
- 2018-11-23
- Last Posted Date
- 2019-04-11
- Lead Sponsor
- Xiangya Hospital of Central South University
- Target Recruit Count
- 100
- Registration Number
- NCT03751111
- Locations
- 🇨🇳
Xiangya Hospital, Changsha, Hunan, China
Rapid Reversal of CNS-Depressant Drug Effect Prior to Brain Death Determination
- Conditions
- Interventions
- First Posted Date
- 2018-11-16
- Last Posted Date
- 2024-10-31
- Lead Sponsor
- Prisma Health-Midlands
- Registration Number
- NCT03743805
- Locations
- 🇺🇸
PRISMA Health Midlands, Columbia, South Carolina, United States
Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF)
- Conditions
- Interventions
- First Posted Date
- 2018-07-31
- Last Posted Date
- 2023-03-17
- Lead Sponsor
- Albert Einstein College of Medicine
- Target Recruit Count
- 17
- Registration Number
- NCT03608163
- Locations
- 🇺🇸
Albert Einstein College of Medicine, Bronx, New York, United States
The Role of Opioidergic Systems in Breathing Based Analgesia
- Conditions
- Interventions
- First Posted Date
- 2018-02-05
- Last Posted Date
- 2019-06-11
- Lead Sponsor
- University of California, San Diego
- Target Recruit Count
- 60
- Registration Number
- NCT03419858
- Locations
- 🇺🇸
Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States
Comparison of Naloxone Pharmacokinetics
- Conditions
- Interventions
- First Posted Date
- 2017-12-29
- Last Posted Date
- 2018-03-09
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Target Recruit Count
- 30
- Registration Number
- NCT03386591
- Locations
- 🇺🇸
Vince and Associates Clinical Research, Overland Park, Kansas, United States
Drug Development Updates
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