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Alvocidib

Generic Name
Alvocidib
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C21H20ClNO5
CAS Number
146426-40-6
Unique Ingredient Identifier
45AD6X575G
Background

Alvocidib is a synthetic flavonoid based on an extract from an Indian plant for the potential treatment of cancer. It works by inhibiting cyclin-dependent kinases, arresting cell division and causing apoptosis in non-small lung cancer cells.

Indication

Investigated for use/treatment in esophageal cancer, leukemia (lymphoid), lung cancer, liver cancer, and lymphoma (unspecified).

Associated Conditions
-
Associated Therapies
-

Combination Chemotherapy in Treating Patients With Advanced Solid Tumors

Phase 1
Completed
Conditions
Unspecified Adult Solid Tumor, Protocol Specific
Interventions
First Posted Date
2003-01-27
Last Posted Date
2014-02-24
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
13
Registration Number
NCT00046917
Locations
🇺🇸

Memorial Sloan-Kettering Cancer Center, New York, New York, United States

Combination Chemotherapy in Treating Patients With Advanced Cancer

Phase 1
Completed
Conditions
Unspecified Adult Solid Tumor, Protocol Specific
Interventions
First Posted Date
2003-01-27
Last Posted Date
2013-12-11
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
90
Registration Number
NCT00021073
Locations
🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

Flavopiridol, Cytarabine, and Mitoxantrone in Treating Patients With Acute Leukemia

Phase 1
Completed
Conditions
Recurrent Adult Acute Lymphoblastic Leukemia
Recurrent Adult Acute Myeloid Leukemia
Secondary Acute Myeloid Leukemia
Untreated Adult Acute Lymphoblastic Leukemia
Untreated Adult Acute Myeloid Leukemia
Interventions
Drug: cytarabine
Drug: mitoxantrone hydrochloride
Drug: alvocidib
Other: pharmacological study
Other: laboratory procedure
First Posted Date
2003-01-27
Last Posted Date
2013-10-08
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
53
Registration Number
NCT00016016
Locations
🇺🇸

Johns Hopkins University, Baltimore, Maryland, United States

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