Overview
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Background
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Indication
For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.
Associated Conditions
- Astrocytoma
- Brain Stem Gliomas
- Ependymoma
- High Grade Glioma: Glioblastoma (GBM)
- Medulloblastomas
- Metastatic Brain Tumors
- Mycosis Fungoides (MF)
- Newly Diagnosed High-Grade Glioma
- Recurrent Glioblastoma Multiforme (GBM)
- Refractory Hodgkin Lymphoma
- Refractory Multiple Myeloma
- Refractory Non-Hodgkin's lymphoma
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2007/05/11 | Phase 2 | Completed | |||
2007/02/23 | Phase 2 | Completed | |||
2006/10/16 | Phase 2 | Completed | |||
2006/08/15 | Phase 2 | Completed | |||
2006/07/10 | Phase 2 | Completed | |||
2006/07/10 | Phase 2 | Completed | |||
2006/06/29 | Phase 2 | Completed | |||
2006/04/24 | Not Applicable | UNKNOWN | European Inter-group Cooperation on Childhood and Adolescent Non Hodgkin Lymphoma | ||
2006/01/30 | Phase 2 | UNKNOWN | Kentuckiana Cancer Institute | ||
2006/01/25 | Phase 2 | Terminated |
FDA Drug Approvals
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Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
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|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
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| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
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|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
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|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
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|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||