Clodronic acid
- Generic Name
- Clodronic acid
- Brand Names
- Clasteon
- Drug Type
- Small Molecule
- Chemical Formula
- CH4Cl2O6P2
- CAS Number
- 10596-23-3
- Unique Ingredient Identifier
- 0813BZ6866
- Background
Clodronic acid is a first generation bisphosphonate similar to etidronic acid and tiludronic acid. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. clodronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate zoledronic acid, ibandronic acid, minodronic acid, and risedronic acid.
Clodronic acid is not FDA approved, but is approved in Canada.
- Indication
Clodronic acid is indicated as an adjunct in the management of osteolysis from bone metastases of malignant tumors and for management of hypercalcemia of malignancy.
- Associated Conditions
- Hypercalcemia of Malignancy, Osteolytic Bone metastases
- Associated Therapies
- -
Clinical Trial to Assess Efficacy, Tolerability of Rising Doses of Clodronate in Painful Knee Osteoarthritis Patients
- First Posted Date
- 2024-02-16
- Last Posted Date
- 2024-02-16
- Lead Sponsor
- SPA Società Prodotti Antibiotici S.p.A.
- Target Recruit Count
- 296
- Registration Number
- NCT06263517
- Locations
- 🇮🇹
Ospedale San Pellegrino, Castiglione delle Stiviere, Mantova, Italy
🇮🇹Ospedale San Pietro, Rome, Italy
🇮🇹Centro Riabilitativo Polifunzionale Teresio Borsalino, Alessandria, Italy
Combined Drug Therapy in Lateral Fragility Fractures of the Femur
- First Posted Date
- 2022-01-10
- Last Posted Date
- 2022-02-04
- Target Recruit Count
- 50
- Registration Number
- NCT05183308
- Locations
- 🇮🇹
AOUC Policlinico di Bari - UOC Ortopedia e Traumatologia, Bari, Italy
Locally Administered Clodronate in the Prevention of Aseptic Implant Loosening
- First Posted Date
- 2019-01-15
- Last Posted Date
- 2019-01-18
- Lead Sponsor
- University of Oulu
- Target Recruit Count
- 19
- Registration Number
- NCT03803839
Trial of Combined Pentoxifylline-tocopherol-clodronate vs Placebo in Radiation-induced Brachial Plexopathy
- First Posted Date
- 2011-02-08
- Last Posted Date
- 2017-12-08
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 59
- Registration Number
- NCT01291433
- Locations
- 🇫🇷
Hôpital Saint-Louis, Paris, France
🇫🇷Groupe Hospitalier Pitié-Salpêtrière, Paris, France
Bisphosphonates and Impaction Grafting in Hip Revision
- Conditions
- Interventions
- First Posted Date
- 2008-04-14
- Last Posted Date
- 2017-08-15
- Lead Sponsor
- Region Skane
- Target Recruit Count
- 32
- Registration Number
- NCT00658268
- Locations
- 🇸🇪
Lund University Hospital, Lund, Sweden
Clodronate With or Without Chemotherapy and/or Hormonal Therapy in Treating Women With Stage I or Stage II Breast Cancer
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2017-12-13
- Lead Sponsor
- NSABP Foundation Inc
- Target Recruit Count
- 3323
- Registration Number
- NCT00009945
- Locations
- 🇺🇸
Altru Cancer Center, Grand Forks, North Dakota, United States
🇺🇸Fletcher Allen Health Care - University Health Center Campus, Burlington, Vermont, United States
🇺🇸CCOP - Mayo Clinic Scottsdale Oncology Program, Scottsdale, Arizona, United States
Drug Development Updates
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