Mecamylamine
- Generic Name
- Mecamylamine
- Brand Names
- Inversine, Vecamyl
- Drug Type
- Small Molecule
- Chemical Formula
- C11H21N
- CAS Number
- 60-40-2
- Unique Ingredient Identifier
- -
- Background
A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
- Indication
For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension
- Associated Conditions
- Severe Hypertension, Moderate Hypertension, Uncomplicated Malignant hypertension
- Associated Therapies
- -
Nicotinic Modulation of the Default Network
- Conditions
- Interventions
- First Posted Date
- 2010-10-19
- Last Posted Date
- 2019-08-19
- Lead Sponsor
- University of Maryland, Baltimore
- Target Recruit Count
- 21
- Registration Number
- NCT01223404
- Locations
- 🇺🇸
National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland, United States
🇺🇸Maryland Psychiatric Research Center, Baltimore, Maryland, United States
Placebo-Controlled Pilot Trial of Mecamylamine for Treatment of Autism Spectrum Disorders
- Conditions
- Interventions
- First Posted Date
- 2008-10-16
- Last Posted Date
- 2017-01-13
- Lead Sponsor
- Ohio State University
- Target Recruit Count
- 20
- Registration Number
- NCT00773812
- Locations
- 🇺🇸
Nisonger Center, Columbus, Ohio, United States
Flexible Dose Titration Add-on Study to Treat Major Depressive Disorder
- First Posted Date
- 2008-01-15
- Last Posted Date
- 2008-01-15
- Lead Sponsor
- Targacept Inc.
- Target Recruit Count
- 450
- Registration Number
- NCT00593879
Mecamylamine for the Treatment of Patients With Depression and Alcohol Dependence
- First Posted Date
- 2007-11-26
- Last Posted Date
- 2016-04-18
- Lead Sponsor
- Yale University
- Target Recruit Count
- 21
- Registration Number
- NCT00563797
- Locations
- 🇺🇸
VA Connecticut Healthcare System, West Haven, Connecticut, United States
Topical Ocular Mecamylamine in Diabetic Macular Edema (DME)
- Conditions
- First Posted Date
- 2007-09-28
- Last Posted Date
- 2008-04-08
- Lead Sponsor
- CoMentis
- Registration Number
- NCT00536692
- Locations
- 🇺🇸
Ophthalmic Consultants of Boston, Boston, Massachusetts, United States
🇺🇸Johns Hopkins School of Medicine / Wilmer Eye Institute, Baltimore, Maryland, United States
🇺🇸East Bay Retina Consultants, Inc., Oakland, California, United States
Study of the Effects of Mecamylamine and Varenicline in Schizophrenia
- Conditions
- Interventions
- First Posted Date
- 2007-04-04
- Last Posted Date
- 2017-03-28
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 89
- Registration Number
- NCT00455650
- Locations
- 🇺🇸
Freedom Trail Clinic, Massachusetts General Hospital, Boston, Massachusetts, United States
Safety and Efficacy of ATG003 in Patients With Wet Age-Related Macular Degeneration (AMD)
- First Posted Date
- 2006-12-21
- Last Posted Date
- 2010-11-23
- Lead Sponsor
- CoMentis
- Target Recruit Count
- 343
- Registration Number
- NCT00414206
- Locations
- 🇲🇽
Hospital San José Tec de Monterrey, Monterrey, Mexico
🇵🇱Oddział Okulistyczny Okręgowy Szpital Kolejowy, Katowice, Poland
🇵🇱Oddział Okulistyki, Samodzielny Publiczny Szpital Kliniczny Nr 1 Przemienienia Pańskiego AM w Poznaniu, Poznań, Poland
Treatment With Mecamylamine in Smoking and Non-smoking Alcohol Dependent Patients
- First Posted Date
- 2006-06-21
- Last Posted Date
- 2019-06-04
- Lead Sponsor
- Yale University
- Target Recruit Count
- 136
- Registration Number
- NCT00342563
- Locations
- 🇺🇸
VA Connecticut Healthcare System, West Haven, Connecticut, United States
Treatment of Orthostatic Intolerance
- Conditions
- Interventions
- Drug: AtomoxetineDrug: AcetazolamideDietary Supplement: MelatoninOther: NO DrugDrug: Isosorbide DinitrateRadiation: PlaceboDevice: Breathing DeviceOther: Drinking WaterProcedure: IV SalineDevice: Abdominal binderDrug: IndomethacinDrug: MidodrineDrug: MecamylamineDrug: ClonidineDrug: EntacaponeDrug: memantineDrug: ModafinilDrug: OctreotideDrug: SertralineDrug: Atomoxetine & PropranololDrug: Entacapone & PropranololDrug: PropranololDrug: Modafinil & Propranolol
- First Posted Date
- 2005-12-06
- Last Posted Date
- 2024-10-02
- Lead Sponsor
- Satish R. Raj
- Target Recruit Count
- 150
- Registration Number
- NCT00262470
- Locations
- 🇺🇸
Vanderbilt University Autonomic Dysfunction Center, Nashville, Tennessee, United States
Combinations of Pharmacologic Smoking Cessation Treatments
- Conditions
- First Posted Date
- 2001-07-05
- Last Posted Date
- 2009-01-21
- Lead Sponsor
- US Department of Veterans Affairs
- Registration Number
- NCT00018187
- Locations
- 🇺🇸
VA Greater Los Angeles Healthcare System, Los Angeles, California, United States
Drug Development Updates
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