Mecamylamine

Overview

A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

Indication

For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension

Associated Conditions

Severe Hypertension
Moderate Hypertension
Uncomplicated Malignant hypertension

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Attentional Mechanisms in SCD	2023/08/21	NCT06002477	Early Phase 1	Recruiting	Vanderbilt University Medical Center
Cholinergic Mechanisms of Attention in Aging	2021/02/16	NCT04756232	Early Phase 1	Recruiting	Vanderbilt University Medical Center
Mecamylamine for Autonomic Dysreflexia Prophylaxis	2019/04/16	NCT03914677	Phase 4	UNKNOWN	Wayne State University
Mental Ability Challenge Study in Adults With and Without HIV	2017/08/09	NCT03244488	N/A	Completed	Vanderbilt University Medical Center
Nicotinic Modulation of the Default Network	2010/10/19	NCT01223404	Not Applicable	Completed	University of Maryland, Baltimore
Placebo-Controlled Pilot Trial of Mecamylamine for Treatment of Autism Spectrum Disorders	2008/10/16	NCT00773812	Phase 1	Completed	Ohio State University
Flexible Dose Titration Add-on Study to Treat Major Depressive Disorder	2008/01/15	NCT00593879	Phase 2	Completed	Targacept Inc.
Mecamylamine for the Treatment of Patients With Depression and Alcohol Dependence	2007/11/26	NCT00563797	Phase 3	Completed	Yale University
Topical Ocular Mecamylamine in Diabetic Macular Edema (DME)	2007/09/28	NCT00536692	Phase 2	Completed	CoMentis
Study of the Effects of Mecamylamine and Varenicline in Schizophrenia	2007/04/04	NCT00455650	Not Applicable	Completed	Massachusetts General Hospital

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
No FDA approvals found for this drug.

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
No TGA approvals found for this drug.

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