Chloroquine
- Generic Name
- Chloroquine
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C18H26ClN3
- CAS Number
- 54-05-7
- Unique Ingredient Identifier
- 886U3H6UFF
- Background
Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria. It was the drug of choice to treat malaria until the development of newer antimalarials such as pyrimethamine, artemisinin, and mefloquine. Chloroquine and its derivative hydroxychloroquine have since been repurposed for the treatment of a number of other c...
- Indication
Chloroquine is indicated to treat infections of P. vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It is also used to treat extraintestinal amebiasis.
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- Associated Conditions
- Discoid Lupus Erythematosus (DLE), Extraintestinal Amebiasis, Malaria, Polymorphic Light Eruption (PLE), Porphyria Cutanea Tarda, Rheumatoid Arthritis, Sarcoidosis, Acute, uncomplicated Malaria
- Associated Therapies
- -
Efficacy of Artemisinin Combination Therapies for the Treatment of Uncomplicated P. Vivax in Pregnancy in Brazil (PAACT-PV)
- Conditions
- Interventions
- First Posted Date
- 2010-04-20
- Last Posted Date
- 2012-04-13
- Lead Sponsor
- Centers for Disease Control and Prevention
- Target Recruit Count
- 16
- Registration Number
- NCT01107145
- Locations
- 🇧🇷
Hospital Geral Maternidade de Cruzeiro do Sul, Cruzeiro do Sul, Acre, Brazil
🇧🇷Centro de Pesquisa em Patologias Tropicais, Porto Velho, Rondonia, Brazil
🇧🇷Hospital Municipal Teonila Alves, Anajas, Para, Brazil
The Chloroquine for Influenza Prevention Trial
- First Posted Date
- 2010-03-02
- Last Posted Date
- 2010-03-02
- Lead Sponsor
- National University Hospital, Singapore
- Target Recruit Count
- 1516
- Registration Number
- NCT01078779
- Locations
- 🇸🇬
Investigational Medicines Unit, National University Hospital, Singapore, Singapore
Study on the Treatment of Vivax Malaria
- Conditions
- Interventions
- First Posted Date
- 2010-02-24
- Last Posted Date
- 2013-08-28
- Lead Sponsor
- University of Oxford
- Target Recruit Count
- 655
- Registration Number
- NCT01074905
- Locations
- 🇹🇭
Shoklo Malaria Research Unit, Mae Sot, Thailand
Extended-dose Chloroquine (ECQ) for Resistant Falciparum Malaria Among Afghan Refugees in Pakistan
- First Posted Date
- 2009-11-25
- Last Posted Date
- 2009-11-25
- Lead Sponsor
- London School of Hygiene and Tropical Medicine
- Target Recruit Count
- 163
- Registration Number
- NCT01019408
- Locations
- 🇵🇰
Adezai Basic Health Unit, Adezai, Nwfp, Pakistan
🇵🇰Baghicha Basic Health Unit, Baghicha, Nwfp, Pakistan
🇵🇰Kagan Basic Health Unit, Kagan, Nwfp, Pakistan
Evaluation of the Immune Response of a HIV Candidate Vaccine After Administration of One Chloroquine Dose
- Conditions
- Interventions
- First Posted Date
- 2009-09-07
- Last Posted Date
- 2018-08-17
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 28
- Registration Number
- NCT00972725
- Locations
- 🇧🇪
GSK Investigational Site, Gent, Belgium
The Effect of Chloroquine in the Treatment of Patients With Dengue
- First Posted Date
- 2009-02-24
- Last Posted Date
- 2009-02-24
- Lead Sponsor
- University of Sao Paulo
- Target Recruit Count
- 132
- Registration Number
- NCT00849602
- Locations
- 🇧🇷
São Paulo University Medical School at Ribeirão Preto, Ribeirão Preto, SP, Brazil
Chloroquine for Reducing Immune Activation in HIV- Infected Individuals
- First Posted Date
- 2009-01-09
- Last Posted Date
- 2014-10-13
- Target Recruit Count
- 70
- Registration Number
- NCT00819390
- Locations
- 🇺🇸
Ucsd, Avrc Crs (701), San Diego, California, United States
🇺🇸Alabama Therapeutics CRS (5801), Birmingham, Alabama, United States
🇺🇸Washington University CRS (2101), St. Louis, Missouri, United States
Pilot Human Study of Tinidazole Efficacy For Radical Cure Of Plasmodium Vivax
- First Posted Date
- 2008-12-18
- Last Posted Date
- 2012-12-03
- Lead Sponsor
- Walter Reed Army Institute of Research (WRAIR)
- Target Recruit Count
- 20
- Registration Number
- NCT00811096
- Locations
- 🇹🇭
Malaria Research Unit, 68/30 Ban Toong Road, P.O. Box 46, Mae Sot, 63110, Tak, Thailand
New Approaches to Improve Coverage and Compliance of Antimalarial Treatment for Pregnant Women in Rural Africa
- Conditions
- Interventions
- First Posted Date
- 2008-08-08
- Last Posted Date
- 2010-09-14
- Lead Sponsor
- Institute of Tropical Medicine, Belgium
- Target Recruit Count
- 2766
- Registration Number
- NCT00730366
- Locations
- 🇧🇫
District Sanitaire, Boromo, Burkina Faso
Artesunate Plus Sulfadoxine-Pyrimethamine Versus Chloroquine for Vivax Malaria
- Conditions
- First Posted Date
- 2007-06-15
- Last Posted Date
- 2007-06-15
- Lead Sponsor
- London School of Hygiene and Tropical Medicine
- Target Recruit Count
- 190
- Registration Number
- NCT00486694
Drug Development Updates
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