Pregabalin

Generic Name: Pregabalin

Brand Names: Lyrica, Pregabalin Accord, Pregabalin Pfizer, Pregabalin Sandoz, Pregabalin Mylan, Pregabalin Zentiva

Drug Type: Small Molecule

Chemical Formula: C_₈H_₁₇NO_₂

CAS Number: 148553-50-8

Unique Ingredient Identifier: 55JG375S6M

Background: Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively defined, there is evidence that pregabalin exerts its effects by binding to the α2δ subunit of voltage-dependent calcium channels. Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release). It may have dependence liability if misused but the risk appears to be highest in patients with current or past substance use disorders.

Indication: Pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury, and as adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older.

Associated Conditions: Diabetic Peripheral Neuropathic Pain (DPN), Epilepsies, Fibromyalgia, Generalized Anxiety Disorder, Neuropathic Pain, Partial-Onset Seizures, Peripheral Neuropathic Pain, Peripheral neuropathy, Postherpetic Neuralgia

Associated Therapies: -

Clinical Trials

Analgetic Effect of Preoperative Pregabalin in Patients Undergoing Nephrectomy

Phase 3

Completed

Conditions: Postoperative Pain

Interventions: Drug: Placebo
Drug: Pregabalin

First Posted Date: 2009-08-12

Last Posted Date: 2011-05-27

Lead Sponsor: Medical University of Graz

Target Recruit Count: 20

Registration Number: NCT00957177

Locations: 🇦🇹
Medical University of Graz, Graz, Austria

Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy

Not Applicable

Terminated

Conditions: Postoperative Pain

Interventions: Drug: Gabapentin
Drug: pregabalin

First Posted Date: 2009-08-07

Last Posted Date: 2017-01-09

Lead Sponsor: Loma Linda University

Target Recruit Count: 8

Registration Number: NCT00954187

Locations: 🇺🇸
Loma Linda University - Ophthalmology, Loma Linda, California, United States

Perioperative Administration of Pregabalin for Pain After Mastectomy

Phase 4

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Vitamin Complex (placebo)
Drug: Pregabalin

First Posted Date: 2009-07-14

Last Posted Date: 2010-05-25

Lead Sponsor: Severance Hospital

Target Recruit Count: 70

Registration Number: NCT00938548

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine and Anesthesia, Seoul, Korea, Republic of

Duloxetine Versus Pregabalin for Alcohol Dependence

Phase 2

Completed

Conditions: Alcohol Dependence

Interventions: Drug: Placebo
Drug: Duloxetine
Drug: Pregabalin
Behavioral: Standardized behavioral therapy

First Posted Date: 2009-06-29

Last Posted Date: 2017-05-04

Lead Sponsor: The Scripps Research Institute

Target Recruit Count: 150

Registration Number: NCT00929344

Locations: 🇺🇸
The Scripps Research Institute Pearson Center for Alcoholism and Addiction Research, La Jolla, California, United States

Efficacy of Pregabalin in Patients With Radicular Pain

Phase 4

Completed

Conditions: Failed Back Surgery Syndrome
Neuropathy; Radicular, Lumbar, Lumbosacral
Herniated Disc
Spinal Stenosis

Interventions: Drug: Sugar Pill
Drug: Pregabalin

First Posted Date: 2009-05-25

Last Posted Date: 2014-10-13

Lead Sponsor: Northwestern University

Target Recruit Count: 39

Registration Number: NCT00908375

Locations: 🇺🇸
Pain Medicine Center, Chicago, Illinois, United States

Perioperative Administration of Pregabalin for Pain After Robot-assisted Endoscopic Thyroidectomy

Phase 4

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Vitamin Complex (placebo)
Drug: Pregabalin

First Posted Date: 2009-05-20

Last Posted Date: 2010-01-20

Lead Sponsor: Severance Hospital

Target Recruit Count: 99

Registration Number: NCT00905580

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea, Republic of