Pregabalin

Generic Name: Pregabalin

Brand Names: Lyrica, Pregabalin Accord, Pregabalin Pfizer, Pregabalin Sandoz, Pregabalin Mylan, Pregabalin Zentiva

Drug Type: Small Molecule

Chemical Formula: C_₈H_₁₇NO_₂

CAS Number: 148553-50-8

Unique Ingredient Identifier: 55JG375S6M

Background: Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively defined, there is evidence that pregabalin exerts its effects by binding to the α2δ subunit of voltage-dependent calcium channels. Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release). It may have dependence liability if misused but the risk appears to be highest in patients with current or past substance use disorders.

Indication: Pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury, and as adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older.

Associated Conditions: Diabetic Peripheral Neuropathic Pain (DPN), Epilepsies, Fibromyalgia, Generalized Anxiety Disorder, Neuropathic Pain, Partial-Onset Seizures, Peripheral Neuropathic Pain, Peripheral neuropathy, Postherpetic Neuralgia

Associated Therapies: -

Clinical Trials

Trial of Pregabalin for Post-operative Pain in Women Undergoing Abdominal Hysterectomy

Phase 4

Completed

Conditions: Opioid Use
Postoperative Pain

Interventions: Drug: Placebo
Drug: Pregabalin

First Posted Date: 2008-10-28

Last Posted Date: 2013-05-23

Lead Sponsor: IWK Health Centre

Target Recruit Count: 101

Registration Number: NCT00781131

Locations: 🇨🇦
IWK Health Centre, Halifax, Nova Scotia, Canada

Chronic Pain Management After Herniorraphy

Phase 3

Completed

Conditions: Chronic Pain

Interventions: Drug: placebo
Drug: pregabalin

First Posted Date: 2008-10-15

Last Posted Date: 2011-08-19

Lead Sponsor: Erasmus Medical Center

Target Recruit Count: 140

Registration Number: NCT00772291

Locations: 🇳🇱
Erasmus Medical Center, Rotterdam, Netherlands

Perioperative Pregabalin Use, Rehabilitation, Pain Outcomes and Anxiety Following Hip Surgery

Phase 4

Conditions: Anxiety

Interventions: Drug: Placebo
Drug: Pregabalin

First Posted Date: 2008-09-30

Last Posted Date: 2011-04-08

Lead Sponsor: Sunnybrook Health Sciences Centre

Target Recruit Count: 184

Registration Number: NCT00762099

Locations: 🇨🇦
Holland Orthopaedic and Arthritic Centre, Toronto, Ontario, Canada

Pain and Chronic Pancreatitis - Clinical End Experimental Studies

Phase 2

Completed

Conditions: Chronic Pancreatitis

Interventions: Drug: placebo
Drug: Pregabalin

First Posted Date: 2008-09-19

Last Posted Date: 2010-08-20

Lead Sponsor: Aalborg University Hospital

Target Recruit Count: 64

Registration Number: NCT00755573

Locations: 🇩🇰
Department of Gastroenterology, Aalborg Hospital, Aalborg, Denmark
🇳🇱
Department of Suregery, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

Investigation of Tolterodine, Pregabalin and a Tolterodine - Pregabalin Combination for the Treatment of Overactive Bladder

Phase 2

Completed

Conditions: Overactive Bladder

Interventions: Drug: Tolterodine & Pregabalin
Drug: Placebo
Drug: Tolterodine
Drug: Pregabalin

First Posted Date: 2008-09-04

Last Posted Date: 2009-12-21

Lead Sponsor: Pfizer

Target Recruit Count: 188

Registration Number: NCT00746681

Locations: 🇬🇧
Pfizer Investigational Site, Plymouth, United Kingdom

Amitriptyline or Pregabalin to Treat Neuropathic Pain in Incurable Cancer

Phase 3

Conditions: Cancer
Neuralgia

Interventions: Drug: pregabalin
Drug: amitriptyline

First Posted Date: 2008-08-25

Last Posted Date: 2009-02-05

Lead Sponsor: Radboud University Medical Center

Target Recruit Count: 130

Registration Number: NCT00740571

Locations: 🇳🇱
Erasmus MC, Rotterdam, Zuid-Holland, Netherlands
🇳🇱
VUMC, Amsterdam, Noord-Holland, Netherlands

Effect of Oral Pregabalin on Spinal Neurotransmitters in Patients Undergoing Knee Replacement

Phase 3

Completed

Conditions: PAIN

Interventions: Drug: Pregabalin
Drug: Placebo

First Posted Date: 2008-08-07

Last Posted Date: 2012-12-19

Lead Sponsor: Asokumar Buvanendran

Target Recruit Count: 48

Registration Number: NCT00729690

Locations: 🇺🇸
Rush University Medical Center, Chicago, Illinois, United States

Pregabalin in Treating Women With Hot Flashes

Phase 3

Completed

Conditions: Breast Cancer
Hot Flashes

Interventions: Drug: pregabalin
Other: placebo

First Posted Date: 2008-06-20

Last Posted Date: 2016-08-01

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 207

Registration Number: NCT00702949

Locations: 🇺🇸
Galesburg Clinic, PC, Galesburg, Illinois, United States
🇺🇸
Perry Memorial Hospital, Princeton, Illinois, United States
🇺🇸
McDonough District Hospital, Macomb, Illinois, United States

and more 204 locations