Pregabalin
- Generic Name
- Pregabalin
- Brand Names
- Lyrica, Pregabalin Accord, Pregabalin Pfizer, Pregabalin Sandoz, Pregabalin Mylan, Pregabalin Zentiva
- Drug Type
- Small Molecule
- Chemical Formula
- C8H17NO2
- CAS Number
- 148553-50-8
- Unique Ingredient Identifier
- 55JG375S6M
- Background
Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively defined, there is evidence that pregabalin exerts its effects by binding to the α2δ subunit of voltage-dependent calcium channels. Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release). It may have dependence liability if misused but the risk appears to be highest in patients with current or past substance use disorders.
- Indication
Pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury, and as adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older.
- Associated Conditions
- Diabetic Peripheral Neuropathic Pain (DPN), Epilepsies, Fibromyalgia, Generalized Anxiety Disorder, Neuropathic Pain, Partial-Onset Seizures, Peripheral Neuropathic Pain, Peripheral neuropathy, Postherpetic Neuralgia
- Associated Therapies
- -
Effects of Pregabalin, Duloxetine & Amitriptyline on Pain & Sleep
- Conditions
- Diabetes MellitusPeripheral Neuropathies
- First Posted Date
- 2006-09-01
- Last Posted Date
- 2009-11-17
- Lead Sponsor
- University of Surrey
- Target Recruit Count
- 90
- Registration Number
- NCT00370656
- Locations
- 🇬🇧
Poole General Hospital, Poole, Dorset, United Kingdom
🇬🇧Royal Bournemouth Hospital, Bournemouth, Dorset, United Kingdom
🇬🇧University of Surrey Clinical Research Centre, Guildford, Surrey, United Kingdom
Efficacy and Safety of Pregabalin vs Placebo for Generalized Anxiety Disorder (GAD) Symptoms in Subjects Discontinuing Benzodiazepine Treatment and Remaining 6 Weeks on Study Medication, Free From Benzodiazepine Use.
- First Posted Date
- 2006-08-25
- Last Posted Date
- 2021-02-09
- Lead Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
- Target Recruit Count
- 108
- Registration Number
- NCT00368745
- Locations
- 🇪🇸
Pfizer Investigational Site, Zamora, Spain
Analgetic and Anxiolytic Effect of Preoperative Pregabalin
- Conditions
- Intervertebral Disk DisplacementDisk Prolapse
- Interventions
- First Posted Date
- 2006-07-19
- Last Posted Date
- 2011-07-20
- Lead Sponsor
- Asker & Baerum Hospital
- Target Recruit Count
- 50
- Registration Number
- NCT00353704
- Locations
- 🇳🇴
Asker and Baerum Hospital, Rud, Norway
Study to Find Out if Therapy With the Drug Pregabalin Relieves Pain During Shingles Compared With Placebo
- Conditions
- Herpes ZosterPostherpetic Neuralgia
- First Posted Date
- 2006-07-14
- Last Posted Date
- 2011-04-14
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 34
- Registration Number
- NCT00352651
- Locations
- 🇺🇸
UCSF Pain Clinical Research Center, San Francisco, California, United States
This Study is An Open-Label Trial Of Pregabalin In Patients With Fibromyalgia
- First Posted Date
- 2006-06-29
- Last Posted Date
- 2021-01-22
- Lead Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
- Target Recruit Count
- 357
- Registration Number
- NCT00346034
- Locations
- 🇬🇧
Pfizer Investigational Site, Poole, United Kingdom
[S,S]-Reboxetine Add-On Trial
- First Posted Date
- 2006-06-08
- Last Posted Date
- 2019-12-16
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 136
- Registration Number
- NCT00334685
- Locations
- 🇬🇧
Pfizer Investigational Site, York, United Kingdom
Randomized, Double-Blind, Placebo-Controlled Trial Of Pregabalin In Patients With Fibromyalgia.
- First Posted Date
- 2006-06-06
- Last Posted Date
- 2021-02-11
- Lead Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
- Target Recruit Count
- 747
- Registration Number
- NCT00333866
- Locations
- 🇻🇪
Pfizer Investigational Site, Caracas, Estado Miranda, Venezuela
Efficacy Of Pregabalin In Subjects With Post-Stroke Central Neuropathic Pain
- First Posted Date
- 2006-04-12
- Last Posted Date
- 2021-02-09
- Lead Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
- Target Recruit Count
- 220
- Registration Number
- NCT00313820
- Locations
- 🇹🇭
Pfizer Investigational Site, Bangkok, Thailand
Effects of Pregabalin on Mechanical Hyperalgesia
- Conditions
- Tactile HyperalgesiaNeuropathic Pain
- First Posted Date
- 2006-04-04
- Last Posted Date
- 2007-04-05
- Lead Sponsor
- Professional Associations Clinic Bergmannsheil
- Target Recruit Count
- 120
- Registration Number
- NCT00310583
- Locations
- 🇩🇪
Dept. of Anaesthesia and Transfusion Medicine, University of Tuebingen, Tuebingen, Germany
🇩🇪Health Care Centre, Dept. of Neurology, Johannes Gutenberg University of Mainz, Mainz, Germany
🇩🇪Interdisciplinary Dept. of Pain Management, Dept. of Anaesthesiology, Ludwig-Maximilians-University, Munich, Germany
A Study to Assess the Efficacy, Safety and Tolerability of Pregabalin in Patients With Symptoms of Neuropathic Pain
- Conditions
- Neuropathic Pain
- First Posted Date
- 2006-03-10
- Last Posted Date
- 2021-01-22
- Lead Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
- Target Recruit Count
- 309
- Registration Number
- NCT00301223
- Locations
- 🇨🇳
Pfizer Investigational Site, Tian Jin, China
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.