Myelin basic protein

Neurological disorders, categorized by neuron loss, acute damage, or impaired function, include Parkinson's, Alzheimer's, stroke, and epilepsy. Mesenchymal stem cells (MSCs), with origins in mesoderm and ectoderm, offer therapeutic potential due to their multipotency and immunomodulatory properties. MSCs can differentiate into neuron-like cells, aiding in treating neurological injuries and diseases. Challenges include immunocompatibility, differentiation control, and avoiding tumor promotion. Advances in MSC therapy involve novel biomaterials and electromagnetic fields to enhance cell retention and survival, despite technical and societal challenges.

INmune Bio Inc. reports financial results for Q3 2024, including a net loss of $12.1 million. Highlights include completion of enrollment for Phase 2 Alzheimer’s Disease trial, interim analysis showing EMACC's exceptional performance, and INKmune™ demonstrating safety and increased NK-Cell activity in a Phase I/II trial for metastatic Castration-Resistant Prostate Cancer.

A new treatment using CRISPR to repair nerve damage in mice shows promise for reversing MS effects, potentially leading to human treatments in the future.

The OCTOPUS trial, assessing R/S alpha-lipoic acid and metformin in progressive MS, updated at ECTRIMS 2024, reports 189 of 375 participants randomized by March 2024. The study aims to address the unmet need for treatments in progressive MS, with ocrelizumab being the only FDA-approved therapy. Lipoic acid and metformin are hypothesized to impact immune response and promote myelin repair, respectively.

Alexandra Klein's research on how deep breathing affects anxiety in mice won first place at UCSF's Postdoc Slam 2024, suggesting potential for breathing therapies in mental health.

Hauser's encounter with Andrea, a young MS patient, inspired his life's work on MS, a disease attacking the brain's myelin. Recent UCSF research, including clemastine's myelin repair and genetic insights, offers hope for reversing MS symptoms and advancing towards a cure.