Dexchlorpheniramine
- Generic Name
- Dexchlorpheniramine
- Drug Type
- Small Molecule
- Chemical Formula
- C16H19ClN2
- CAS Number
- 25523-97-1
- Unique Ingredient Identifier
- 3Q9Q0B929N
- Background
Dexchlorpheniramine is a potent S-enantiomer of chlorpheniramine. The salt form dexchlorpheniramine maleate as the active ingredient is available as a prescription drug indicated for adjunctive therapy for allergic and anaphylactic reactions. It is an antihistamine drug with anticholinergic (drying) and sedative actions. It disrupts histamine signaling by competing with histamine for cell receptor sites on effector cells.
- Associated Conditions
- Allergy to Tree Pollen, Common Cold, Conjunctivitis, Dermatitis, Insect Bites, Pruritus, Rhinitis, Sunburn, Urticaria, Vasomotor Rhinitis
Induction Therapy for Lupus Nephritis With no Added Oral Steroids: A Trial Comparing Oral Corticosteroids Plus Mycophenolate Mofetil (MMF) Versus Obinutuzumab and MMF
- Conditions
- Lupus NephritisSystemic Lupus Erythematosus (SLE)
- Interventions
- First Posted Date
- 2021-01-08
- Last Posted Date
- 2023-03-16
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 196
- Registration Number
- NCT04702256
- Locations
- 🇫🇷
Internal medicine, Cochin hospital, APHP, Paris, France
A Study to Evaluate Efficacy, Safety, and Tolerability of Alemtuzumab in Pediatric Patients With RRMS With Disease Activity on Prior DMT
- Conditions
- Multiple Sclerosis
- Interventions
- Drug: Beta-InterferonDrug: CeterizineDrug: DiphenydramineDrug: Other H1 antagonist
- First Posted Date
- 2017-12-11
- Last Posted Date
- 2023-09-21
- Lead Sponsor
- Genzyme, a Sanofi Company
- Target Recruit Count
- 16
- Registration Number
- NCT03368664
- Locations
- 🇹🇷
Investigational Site Number :7920002, Ankara, Turkey
🇹🇷Investigational Site Number :7920001, Ankara, Turkey
🇫🇷Investigational Site Number :2500002, Strasbourg, France
Hemodynamic Instability Prevented With Polaramine® Infusion Before Extracorporeal Circulation
- Conditions
- Hemodynamic InstabilityVasoplegic Syndrome
- Interventions
- Drug: Placebo injection
- First Posted Date
- 2016-02-05
- Last Posted Date
- 2020-05-13
- Lead Sponsor
- University Hospital, Bordeaux
- Target Recruit Count
- 18
- Registration Number
- NCT02675374
- Locations
- 🇫🇷
CHU de Bordeaux, Pessac, France
A Study to Characterize Subcutaneous or Intravenous Alemtuzumab in Patients With Progressive Multiple Sclerosis
- Conditions
- Progressive Multiple Sclerosis
- Interventions
- First Posted Date
- 2015-10-22
- Last Posted Date
- 2021-03-10
- Lead Sponsor
- Genzyme, a Sanofi Company
- Target Recruit Count
- 24
- Registration Number
- NCT02583594
- Locations
- 🇪🇸
Investigational Site Number 724001, Barcelona, Spain
Combination of Cabazitaxel With Prednisolone With Primary Prophylaxis With PEG-G-CSF in Treatment of Patients With Prostate Cancer
- Conditions
- Prostate Cancer
- Interventions
- First Posted Date
- 2015-05-12
- Last Posted Date
- 2017-01-24
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 21
- Registration Number
- NCT02441894
- Locations
- 🇯🇵
Investigational Site Number 392008, Kita-gun, Japan
🇯🇵Investigational Site Number 392001, Shinjuku-ku, Tokyo, Japan
🇯🇵Investigational Site Number 392004, Chuo-ku, Chiba, Japan
Comparison of Desloratadine Associated With Prednisolone (Tablet)Versus Dexchlorpheniramine Associated With Betamethasone (Tablet) for Adult Persistent Allergic Rhinitis Treatment
- Conditions
- Allergic Rhinitis
- Interventions
- First Posted Date
- 2012-11-02
- Last Posted Date
- 2013-09-25
- Lead Sponsor
- EMS
- Target Recruit Count
- 234
- Registration Number
- NCT01720485
- Locations
- 🇧🇷
IMA - Instituto de Pesquisa Clínica e Medicina Avançada, São Paulo, Brazil
Comparison of Desloratadine Associated With Prednisolone Oral Solution Versus Dexchlorpheniramine Associated With Betamethasone for Cutaneous Rash Treatment
- Conditions
- Cutaneous Hypersensitivity
- Interventions
- First Posted Date
- 2012-02-08
- Last Posted Date
- 2017-02-16
- Lead Sponsor
- EMS
- Target Recruit Count
- 17
- Registration Number
- NCT01529242
- Locations
- 🇧🇷
Allergisa, Campinas, São Paulo, Brazil
🇧🇷Hospital Nipo Brasileiro, São Paulo, Brazil
🇧🇷Alergoalpha, São Paulo, SP, Brazil
Comparison of Desloratadine Associated With Prednisolone Oral Solution Versus Dexchlorpheniramine Associated With Betamethasone for Persistent Allergic Rhinitis Treatment
- Conditions
- Allergic Rhinitis
- Interventions
- First Posted Date
- 2012-02-08
- Last Posted Date
- 2015-01-15
- Lead Sponsor
- EMS
- Target Recruit Count
- 210
- Registration Number
- NCT01529229
Non-inferiority Clinical Trial of Dexchlorpheniramine (Cream Versus Gel) in the Relief of Sunburn Related Symptoms
- Conditions
- Sunburn
- Interventions
- First Posted Date
- 2010-11-10
- Last Posted Date
- 2010-11-10
- Lead Sponsor
- Mantecorp Industria Quimica e Farmaceutica Ltd.
- Target Recruit Count
- 124
- Registration Number
- NCT01237925
- Locations
- 🇧🇷
Medcin Instituto da Pele Ltda, Osasco, São Paulo, Brazil
Comparative Study of Two Forms of Topical Dexchlorpheniramine Maleate (Cream Versus Gel) for Insect Bites
- Conditions
- Insect Bites
- Interventions
- First Posted Date
- 2010-11-03
- Last Posted Date
- 2010-11-03
- Lead Sponsor
- Mantecorp Industria Quimica e Farmaceutica Ltd.
- Target Recruit Count
- 90
- Registration Number
- NCT01233934
- Locations
- 🇧🇷
Medcin Instituto da Pele Ltda., Osasco, São Paulo, Brazil
Drug Development Updates
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