A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.
Cytarabine is indicated in combination with daunorubicin for the treatment of newly-diagnosed therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC) in adults and pediatric patients 1 year and older.
University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida, United States
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States
Children's Hospital of Minnesota - Minneapolis, Minneapolis, Minnesota, United States
Ohio State University Medical Center, Columbus, Ohio, United States
Cancer Center and Beckman Research Institute, City of Hope, Duarte, California, United States
University of Nebraska Medical Center, Omaha, Nebraska, United States
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C., Syracuse, New York, United States
Veterans Affairs Medical Center - Dallas, Dallas, Texas, United States
CCOP - Mount Sinai Medical Center, Miami Beach, Florida, United States
Children's Oncology Group, Arcadia, California, United States
St. Luke's Mountain States Tumor Institute - Boise, Boise, Idaho, United States
Providence Cancer Institute at Providence Hospital - Southfield Campus, Southfield, Michigan, United States
Munson Medical Center, Traverse City, Michigan, United States
The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States
University of Texas - MD Anderson Cancer Center, Houston, Texas, United States
Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support, Bethesda, Maryland, United States
National Cancer Institute of Egypt, Cairo, Egypt
Kidwai Memorial Institute of Oncology, Bangalore, India
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