Overview
Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA approved on October 14, 2011.
Indication
Deferiprone is indicated in thalassemia syndromes when first line chelation agents are not adequate to treat transfusional iron overload.
Associated Conditions
- Transfusional Iron Overload
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2025/06/17 | Phase 2 | Not yet recruiting | |||
2022/11/03 | Phase 2 | Recruiting | Rohan Dharmakumar | ||
2021/11/08 | Phase 2 | Recruiting | University Hospital, Bordeaux | ||
2019/12/03 | Early Phase 1 | UNKNOWN | |||
2019/01/14 | Phase 2 | Completed | |||
2018/11/27 | Phase 1 | Recruiting | |||
2018/07/19 | Phase 4 | Completed | |||
2017/09/26 | Phase 2 | Active, not recruiting | University Hospital, Lille | ||
2017/07/31 | Phase 2 | Completed | |||
2016/12/02 | Phase 1 | Completed | SocraTec R&D GmbH |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Sun Pharmaceutical Industries, Inc. | 51672-4237 | ORAL | 1000 mg in 1 1 | 5/19/2025 | |
| Hikma Pharmaceuticals USA Inc. | 0054-0711 | ORAL | 1000 mg in 1 1 | 8/1/2023 | |
| Chiesi USA, Inc. | 10122-100 | ORAL | 500 mg in 1 1 | 3/31/2025 | |
| Chiesi USA, Inc. | 10122-104 | ORAL | 1000 mg in 1 1 | 3/31/2025 | |
| ApoPharma USA, Inc. | 52609-0007 | ORAL | 1000 mg in 1 1 | 4/27/2011 | |
| Chiesi USA, Inc. | 10122-100 | ORAL | 500 mg in 1 1 | 8/14/2021 | |
| Chiesi USA, Inc. | 10122-103 | ORAL | 1000 mg in 1 1 | 3/31/2025 | |
| ApoPharma USA, Inc. | 52609-0006 | ORAL | 500 mg in 1 1 | 4/27/2011 | |
| Hikma Pharmaceuticals USA Inc. | 0054-0576 | ORAL | 500 mg in 1 1 | 8/1/2023 | |
| Chiesi USA, Inc. | 10122-101 | ORAL | 100 mg in 1 mL | 1/5/2021 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
Authorised | 8/25/1999 | ||
Authorised | 9/19/2018 |
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| FERRIPROX FILM-COATED TABLET 500 mg | SIN12083P | TABLET, FILM COATED | 500mg | 9/25/2002 | |
| FERRIPROX 100MG/ML ORAL SOLUTION | SIN13668P | SOLUTION | 100.00g/l | 6/26/2009 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| Deferiprone Tablets | 国药准字HJ20140379 | 化学药品 | 片剂 | 5/30/2024 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| FERRIPROX deferiprone 500mg tablets bottle | 93946 | Medicine | A | 4/9/2003 | |
| FERRIPROX deferiprone 50g/500mL oral solution bottle | 125666 | Medicine | A | 3/26/2008 | |
| FERRIPROX deferiprone 25g/250mL oral solution bottle | 125665 | Medicine | A | 3/26/2008 | |
| FERRIPROX deferiprone 1000 mg film-coated tablet bottle | 280204 | Medicine | A | 7/6/2017 |
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