Furosemide (DB00695): A Comprehensive Clinical and Pharmacological Monograph

Drug Identification and Physicochemical Properties

Overview and Nomenclature

Furosemide is a potent, small-molecule loop diuretic that serves as a cornerstone in the management of fluid overload and hypertension.[1] Chemically classified as an anthranilic acid derivative, its primary therapeutic action is achieved through the inhibition of the sodium-potassium-chloride symporter (NKCC), a mechanism that places it in the class of NKCC inhibitors.[1] It is also categorized as an antihypertensive agent.[1]

The drug is universally recognized by its generic name, Furosemide, which is the recommended International Non-Proprietary Name (rINN).[5] An alternative name, Frusemide, was historically the British Approved Name and is still found in use in some regions.[3] Commercially, Furosemide is most famously known by the brand name Lasix, a name anecdotally derived from its typical duration of action, which "lasts six" hours.[1] Other notable brand names include Furoscix and Salix.[1] In major markets such as the United Kingdom and the United States, Furosemide is available by prescription only.[8]

Regulatory and Chemical Identifiers

To ensure unambiguous identification in clinical, research, and regulatory contexts, Furosemide is assigned a comprehensive set of identifiers. These standardized codes and names are essential for accurate data retrieval, reporting, and global pharmacovigilance.