Amlodipine

Generic Name: Amlodipine

Brand Names: Amlobenz, Azor, Caduet, Dafiro, Exforge, Exforge Hct, Katerzia, Lotrel, Norliqva, Norvasc, Prestalia, Tribenzor, Twynsta, Viacoram

Drug Type: Small Molecule

Chemical Formula: C_₂₀H_₂₅ClN_₂O_₅

CAS Number: 88150-42-9

Unique Ingredient Identifier: 1J444QC288

Background: Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities than other calcium channel blockers .

Amlodipine is commonly used in the treatment of high blood pressure and angina. Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), an important vasodilator that decreases blood pressure . The option for single daily dosing of amlodipine is an attractive feature of this drug .

Indication: Amlodipine may be used alone or in combination with other antihypertensive and antianginal agents for the treatment of the following conditions :

• Hypertension

• Coronary artery disease

• Chronic stable angina

• Vasospastic angina (Prinzmetal’s or Variant angina)

• Angiographically documented coronary artery disease in patients without heart failure or an ejection fraction < 40%

Associated Conditions: Cardiovascular Events, Chronic Stable Angina Pectoris, Coronary Artery Disease (CAD), Homozygous Familial Hypercholesterolaemia (HoFH), Hypertension, Hypertension, Essential Hypertension, Mixed Dyslipidemias, Primary Hypercholesterolemia, Vasospastic Angina

Associated Therapies: -

Clinical Trials

Drug-drug Interaction Study (Telmisartan, Amlodipine, Chlorthalidone)

Phase 1

Completed

Conditions: Hypertension

Interventions: Drug: Telmisartan
Drug: Amlodipine
Drug: Chlorthalidone

First Posted Date: 2014-06-02

Last Posted Date: 2014-11-19

Lead Sponsor: Yuhan Corporation

Target Recruit Count: 66

Registration Number: NCT02152969

Locations: 🇰🇷
The Catholic University of Korea Seoul St.Mary's Hospital, Seoul, Korea, Republic of

Ambulatory vs Office BP Management Usual Care for Diagnosing and Managing Hypertension: A Pilot Study

Not Applicable

Completed

Conditions: Hypertension

Interventions: Drug: Amlodipine
Drug: Chlorthalidone
Drug: Losartan

First Posted Date: 2014-04-23

Last Posted Date: 2017-02-10

Lead Sponsor: Anthony J Viera, MD, MPH

Target Recruit Count: 28

Registration Number: NCT02121041

Locations: 🇺🇸
University of North Carolina, Chapel Hill, North Carolina, United States

Amlodipine for Myocardial Iron in Thalassemia

Phase 2

Completed

Conditions: Thalassemia

Interventions: Drug: Standard Chelation
Drug: Amlodipine

First Posted Date: 2014-02-19

Last Posted Date: 2017-06-29

Lead Sponsor: Aga Khan University

Target Recruit Count: 20

Registration Number: NCT02065492

Locations: 🇵🇰
Aga Khan University Hospital, Karachi, Sindh, Pakistan

CKD-330 Drug-Drug Interaction Study (Amlodipine)

Phase 1

Completed

Conditions: Hypertension

Interventions: Drug: Amlodipine 10mg/Candesartan 32mg
Drug: Amlodipine 10mg

First Posted Date: 2014-02-17

Last Posted Date: 2014-08-15

Lead Sponsor: Chong Kun Dang Pharmaceutical

Target Recruit Count: 24

Registration Number: NCT02064556

Locations: 🇰🇷
Asan Medical Center, Seoul, Songpa-gu, Korea, Republic of

A Phase 2 Dose Selection Trial of Candesartan Cilexetil and Amlodipine Besylate to Treat Essential Hypertension

Phase 2

Conditions: Essential Hypertension

Interventions: Drug: Amlodipine 5mg
Drug: Amlodipine 10mg
Drug: Candesartan Cilexetil 8mg
Drug: Candesartan cilexetil 16mg

First Posted Date: 2014-02-11

Last Posted Date: 2014-04-30

Lead Sponsor: HK inno.N Corporation

Target Recruit Count: 384

Registration Number: NCT02059616

Locations: 🇰🇷
Dong-A University Hospital, Busan, Korea, Republic of
🇰🇷
Hallym University Sacred Heart hospital, Kyungki-do, Korea, Republic of
🇰🇷
Inha University Hospital, Incheon, Korea, Republic of

and more 17 locations