Amlodipine
- Generic Name
- Amlodipine
- Brand Names
- Amlobenz, Azor, Caduet, Dafiro, Exforge, Exforge Hct, Katerzia, Lotrel, Norliqva, Norvasc, Prestalia, Tribenzor, Twynsta, Viacoram
- Drug Type
- Small Molecule
- Chemical Formula
- C20H25ClN2O5
- CAS Number
- 88150-42-9
- Unique Ingredient Identifier
- 1J444QC288
- Background
Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnorma...
- Indication
Amlodipine may be used alone or in combination with other antihypertensive and antianginal agents for the treatment of the following conditions :
• Hypertension
• Coronary artery disease
• Chronic stable angina
• Vasospastic angina (Prinzmetal’s or Variant angina)
...
- Associated Conditions
- Cardiovascular Events, Chronic Stable Angina Pectoris, Coronary Artery Disease (CAD), Homozygous Familial Hypercholesterolaemia (HoFH), Hypertension, Hypertension, Essential Hypertension, Mixed Dyslipidemias, Primary Hypercholesterolemia, Vasospastic Angina
- Associated Therapies
- -
Amlodipine on Blood Flow of Preovulatory Follicle in Polycystic Ovarian Patients
- Conditions
- Interventions
- First Posted Date
- 2015-09-09
- Last Posted Date
- 2016-03-25
- Lead Sponsor
- Ahmed Fathy Ali Mohamed Ghanem
- Target Recruit Count
- 60
- Registration Number
- NCT02544776
Amlodipine as Adjuvant Treatment to Iron Chelation for Prevention of Cardiac Iron Overload in Thalassemia Patients
- First Posted Date
- 2015-06-17
- Last Posted Date
- 2016-10-26
- Lead Sponsor
- Kevin H.M. Kuo, MD, MSc, FRCPC
- Target Recruit Count
- 60
- Registration Number
- NCT02474420
- Locations
- 🇨🇦
University Health Network, Toronto, Ontario, Canada
RAS Peptide Profiles in Patients With Arterial Hypertension
- Conditions
- Interventions
- First Posted Date
- 2015-05-20
- Last Posted Date
- 2019-02-22
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 107
- Registration Number
- NCT02449811
- Locations
- 🇨🇭
University Hospital, Basel, Switzerland
Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension
- Conditions
- Interventions
- First Posted Date
- 2015-04-09
- Last Posted Date
- 2018-11-15
- Target Recruit Count
- 42
- Registration Number
- NCT02412761
- Locations
- 🇺🇸
University of Texas at Houston Medical School; Pediatric Nephrology and Hypertension Clinics, Houston, Texas, United States
Effects of Metoprolol and Amlodipine on Cardiac Remodeling, Arrhythmias and Blood Pressure Variation in Hypertensive Patients With Sleep Apnea Syndrome
- First Posted Date
- 2015-04-03
- Last Posted Date
- 2017-02-15
- Target Recruit Count
- 20
- Registration Number
- NCT02408172
- Locations
- 🇨🇳
Portable polysomnography, Suzhou, Jiangsu, China
🇭🇺Twenty-four-hour ambulatory BP monitoring, Budapest, Hungary
Study to Evaluate the Pharmacokinetic Interaction and Safety After Multiple Oral Doses of Fimasartan/Amlodipine and Rosuvastatin in Healthy Male Subjects
- Conditions
- Interventions
- First Posted Date
- 2015-03-25
- Last Posted Date
- 2015-07-23
- Lead Sponsor
- Boryung Pharmaceutical Co., Ltd
- Target Recruit Count
- 50
- Registration Number
- NCT02397538
- Locations
- 🇰🇷
Inje University Busan Paik Hospital, Busan, Korea, Republic of, Korea, Republic of
INTERVENCION Trial
- Conditions
- Interventions
- First Posted Date
- 2015-02-26
- Last Posted Date
- 2015-10-21
- Lead Sponsor
- Prevencion
- Target Recruit Count
- 120
- Registration Number
- NCT02373163
- Locations
- 🇵🇪
Centro de Investigacion PREVENCION, Arequipa, AQP, Peru
A Study to Evaluate the Efficacy and Safety of Amlodipine Besylate and Candesartan Cilexetil in Essential Hypertension Patient Who Are Not Adequately Controlled With Amlodipine Besylate Monotherapy
- Conditions
- Interventions
- First Posted Date
- 2015-02-23
- Last Posted Date
- 2023-05-06
- Lead Sponsor
- HK inno.N Corporation
- Target Recruit Count
- 180
- Registration Number
- NCT02368665
- Locations
- 🇰🇷
Hallym University Sungsim Hospital, Anyang-si, Korea, Republic of
🇰🇷Inje University Busan Baik Hospital, Busan, Korea, Republic of
🇰🇷Chonnam National University Hospital, Gwangju, Korea, Republic of
Pharmacokinetics of Amlodipine Besylate at Delivery and During Lactation
- First Posted Date
- 2015-02-03
- Last Posted Date
- 2019-02-06
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Target Recruit Count
- 16
- Registration Number
- NCT02353806
- Locations
- 🇺🇸
Parkland Health and Hospital System, Dallas, Texas, United States
Effects of Fimasartan on Insulin Secretion in Type 2 Diabetic Patients
- Conditions
- Interventions
- First Posted Date
- 2014-12-09
- Last Posted Date
- 2017-04-28
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 46
- Registration Number
- NCT02312375
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Drug Development Updates
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