Valproic acid
- Generic Name
- Valproic acid
- Brand Names
- Depakene, Depakote, Epival
- Drug Type
- Small Molecule
- Chemical Formula
- C8H16O2
- CAS Number
- 99-66-1
- Unique Ingredient Identifier
- 614OI1Z5WI
- Background
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects o...
- Indication
Indicated for:
1) Use as monotherapy or adjunctive therapy in the management of complex partial seizures and simple or complex absence seizures.
2) Adjunctive therapy in the management of multiple seizure types that include absence seizures.
3) Prophylaxis of migraine headaches.
4) Acute management of mania associated with bipolar disorder.
...
- Associated Conditions
- Bipolar Disorder (BD), Complex Partial Seizure Disorder, Depressive Episodes, Migraine, Petit Mal Epilepsy, Seizure, multiple types, Acute Manic episode
- Associated Therapies
- -
Zidovudine, Interferon Alfa-2b, PEG-Interferon Alfa-2b in Patients With HTLV-I Associated Adult T-Cell Leukemia/Lymphoma
- Conditions
- Interventions
- First Posted Date
- 2009-03-03
- Last Posted Date
- 2018-04-17
- Lead Sponsor
- University of Miami
- Target Recruit Count
- 13
- Registration Number
- NCT00854581
- Locations
- 🇺🇸
University of Miami Sylvester Comprehensive Cancer Center - Miami, Miami, Florida, United States
Study of Efficacy and Safety of Valproic Acid in Chronic Lymphocytic Leukemia (CLL)
- First Posted Date
- 2008-12-18
- Last Posted Date
- 2008-12-18
- Target Recruit Count
- 10
- Registration Number
- NCT00810680
- Locations
- 🇮🇳
Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, Delhi, India
Effectiveness of Combined Medication Treatment for Aggression in Children With Attention Deficit With Hyperactivity Disorder (The SPICY Study)
- First Posted Date
- 2008-11-20
- Last Posted Date
- 2012-07-16
- Lead Sponsor
- Joseph Blader
- Target Recruit Count
- 270
- Registration Number
- NCT00794625
- Locations
- 🇺🇸
Stony Brook University Medical Center, Stony Brook, New York, United States
🇺🇸University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States
🇺🇸North Shore - LIJ Health System, Zucker Hillside Hospital, Glen Oaks, New York, United States
Bipolar Disorder in Late Life
- First Posted Date
- 2008-11-10
- Last Posted Date
- 2014-07-31
- Lead Sponsor
- Duke University
- Target Recruit Count
- 19
- Registration Number
- NCT00787930
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
Antiepileptic Drugs and Vascular Risk Markers
- Conditions
- Interventions
- First Posted Date
- 2008-10-17
- Last Posted Date
- 2017-12-18
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 52
- Registration Number
- NCT00774306
To Evaluate the Efficiency and Safety of Quetiapine Fumarate in the Treatment of Acute Manic Patients With Bipolar Disorder.
- Conditions
- Interventions
- First Posted Date
- 2008-08-28
- Last Posted Date
- 2008-08-28
- Lead Sponsor
- Shanghai Jiao Tong University School of Medicine
- Target Recruit Count
- 70
- Registration Number
- NCT00742638
- Locations
- 🇨🇳
Shanghai Mental Health Center, Shanghai, Shanghai, China
Comparing The Effect On Cognition Of Adjunctive Therapy With Zonisamide Versus Sodium Valproate
- First Posted Date
- 2008-07-11
- Last Posted Date
- 2015-11-03
- Lead Sponsor
- Eisai Limited
- Target Recruit Count
- 2
- Registration Number
- NCT00713622
- Locations
- 🇫🇮
Kuopio University Hospital, Kuopio, Finland
🇦🇹Universitae Klinik fur Neurologiet, Innsbruck, Austria
Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM)
- Conditions
- Interventions
- First Posted Date
- 2008-05-21
- Last Posted Date
- 2015-12-03
- Lead Sponsor
- University of Sao Paulo
- Target Recruit Count
- 60
- Registration Number
- NCT00681980
- Locations
- 🇧🇷
Institute of Tropical Medicine at Sao Paulo University, Sao Paulo, SP, Brazil
Valproic Acid in Treating Patients With Progressive, Non-Metastatic Prostate Cancer
- Conditions
- Interventions
- First Posted Date
- 2008-05-01
- Last Posted Date
- 2018-09-28
- Target Recruit Count
- 15
- Registration Number
- NCT00670046
- Locations
- 🇺🇸
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States
Study to Evaluate the Efficacy and Safety of Aripiprazole Administered With Lithium or Valproate Over 12 Weeks in the Treatment of Mania in Bipolar I Disorder
- Conditions
- Interventions
- First Posted Date
- 2008-04-23
- Last Posted Date
- 2013-12-02
- Target Recruit Count
- 493
- Registration Number
- NCT00665366
- Locations
- 🇹🇷
Local Institution, Denizli, Turkey
Drug Development Updates
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