Valproic acid
- Generic Name
- Valproic acid
- Brand Names
- Depakene, Depakote, Epival
- Drug Type
- Small Molecule
- Chemical Formula
- C8H16O2
- CAS Number
- 99-66-1
- Unique Ingredient Identifier
- 614OI1Z5WI
- Background
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects o...
- Indication
Indicated for:
1) Use as monotherapy or adjunctive therapy in the management of complex partial seizures and simple or complex absence seizures.
2) Adjunctive therapy in the management of multiple seizure types that include absence seizures.
3) Prophylaxis of migraine headaches.
4) Acute management of mania associated with bipolar disorder.
...
- Associated Conditions
- Bipolar Disorder (BD), Complex Partial Seizure Disorder, Depressive Episodes, Migraine, Petit Mal Epilepsy, Seizure, multiple types, Acute Manic episode
- Associated Therapies
- -
Atypical Antipsychotics for Continuation and Maintenance Treatment After an Acute Manic Episode
- Conditions
- Interventions
- First Posted Date
- 2013-11-06
- Last Posted Date
- 2015-11-20
- Lead Sponsor
- University of British Columbia
- Target Recruit Count
- 159
- Registration Number
- NCT01977300
- Locations
- 🇨🇦
University of British Columbia, Vancouver, British Columbia, Canada
Established Status Epilepticus Treatment Trial
- Conditions
- Interventions
- First Posted Date
- 2013-10-10
- Last Posted Date
- 2021-06-14
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 478
- Registration Number
- NCT01960075
- Locations
- 🇺🇸
Children's Medical Center UTSW, Dallas, Texas, United States
🇺🇸Nationwide Children's Hospital, Columbus, Ohio, United States
🇺🇸UPMC Mercy Hospital, Pittsburgh, Pennsylvania, United States
A Study to Evaluate the Safety and Tolerability of Valproic Acid in Healthy Volunteers (Part 1)
- Conditions
- Interventions
- First Posted Date
- 2013-09-26
- Last Posted Date
- 2016-12-19
- Lead Sponsor
- Dr. Hasan Alam
- Target Recruit Count
- 59
- Registration Number
- NCT01951560
- Locations
- 🇺🇸
The University of Michigan, Ann Arbor, Michigan, United States
Valproic Acid for the Prevention of Post-Amputation Pain
- Conditions
- Interventions
- First Posted Date
- 2013-08-27
- Last Posted Date
- 2018-12-19
- Lead Sponsor
- Duke University
- Target Recruit Count
- 128
- Registration Number
- NCT01928849
- Locations
- 🇺🇸
Duham VA Medical Center, Durham, North Carolina, United States
🇺🇸Walter Reed National Military Medical Center, Bethesda, Maryland, United States
Preoperative Valproic Acid and Radiation Therapy for Rectal Cancer
- Conditions
- Interventions
- First Posted Date
- 2013-07-12
- Last Posted Date
- 2023-03-24
- Lead Sponsor
- National Cancer Institute, Naples
- Target Recruit Count
- 152
- Registration Number
- NCT01898104
- Locations
- 🇮🇹
Istituto Nazionale Tumori Fondazione G. Pascale, Napoli, Italy
Comparative Efficacy and Acceptability of Antimanic Drugs in Acute Mania
- Conditions
- Interventions
- First Posted Date
- 2013-07-08
- Last Posted Date
- 2015-03-17
- Lead Sponsor
- Guiyun Xu
- Target Recruit Count
- 120
- Registration Number
- NCT01893229
- Locations
- 🇨🇳
Guangzhou Psychiatric Hospital, Guangzhou, Guangdong, China
Valproic Acid in Childhood Progressive Brain Tumors
- Conditions
- Interventions
- First Posted Date
- 2013-05-24
- Last Posted Date
- 2015-05-22
- Lead Sponsor
- Medical University of South Carolina
- Registration Number
- NCT01861990
- Locations
- 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States
Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade Glioma
- Conditions
- Interventions
- First Posted Date
- 2013-03-25
- Last Posted Date
- 2024-07-17
- Lead Sponsor
- Virginia Commonwealth University
- Target Recruit Count
- 47
- Registration Number
- NCT01817751
- Locations
- 🇺🇸
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, United States
Haloperidol vs. Valproate in Agitation
- First Posted Date
- 2012-12-17
- Last Posted Date
- 2013-01-08
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Target Recruit Count
- 56
- Registration Number
- NCT01750541
- Locations
- 🇮🇷
Department of Emergency Medicine, Imam Hossein Hospital, Tehran, Iran, Islamic Republic of
Impact of Valproate on Angiogenesis and Histone Deacetylation in Bladder Cancer
- First Posted Date
- 2012-11-30
- Last Posted Date
- 2021-10-22
- Target Recruit Count
- 43
- Registration Number
- NCT01738815
- Locations
- 🇺🇸
SUNY Upstate Medical University, Syracuse, New York, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.