Prucalopride
- Generic Name
- Prucalopride
- Brand Names
- Motegrity, Resolor, Resotran
- Drug Type
- Small Molecule
- Chemical Formula
- C18H26ClN3O3
- CAS Number
- 179474-81-8
- Unique Ingredient Identifier
- 0A09IUW5TP
- Background
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride...
- Indication
Prucalopride is indicated for the treatment of chronic idiopathic constipation (CIC) in adults.
CIC is one of the most common chronic functional gastrointestinal disorders worldwide. The diagnosis of this agent is very hard and it can be confirmed if the patient experience at least two of the following:
...
- Associated Conditions
- Opioid Induced Constipation (OIC), Chronic idiopathic constipation (CIC), Refractory Chronic idiopathic constipation
- Associated Therapies
- -
Prucalopride Treatment for Refractory Gastro-esophageal Reflux Disease
- First Posted Date
- 2018-09-18
- Last Posted Date
- 2019-12-05
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Target Recruit Count
- 60
- Registration Number
- NCT03676374
- Locations
- 🇧🇪
UZ Leuven, Leuven, Belgium
Effects of Seven Day Prucalopride Administration in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2018-06-28
- Last Posted Date
- 2022-11-18
- Lead Sponsor
- University of Oxford
- Target Recruit Count
- 50
- Registration Number
- NCT03572790
- Locations
- 🇬🇧
University of Oxford, Oxford, United Kingdom
Effect of PEG, Bisacodyl and Prucalopride on Colonic Motility in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2017-09-12
- Last Posted Date
- 2017-09-12
- Lead Sponsor
- University Hospital, Gasthuisberg
- Target Recruit Count
- 10
- Registration Number
- NCT03279341
- Locations
- 🇧🇪
TARGID, Leuven, Belgium
Treatment of Dysphagia and Ineffective Esophageal Motility With Prucalopride: A Pilot Study
- First Posted Date
- 2017-08-09
- Last Posted Date
- 2020-03-25
- Lead Sponsor
- University of Calgary
- Target Recruit Count
- 28
- Registration Number
- NCT03244553
- Locations
- 🇨🇦
University of Calgary, Calgary, Alberta, Canada
Prucalopride in Postoperative Ileus
- Conditions
- Interventions
- First Posted Date
- 2016-10-27
- Last Posted Date
- 2021-09-29
- Lead Sponsor
- University of Auckland, New Zealand
- Target Recruit Count
- 150
- Registration Number
- NCT02947269
- Locations
- 🇳🇿
University of Auckland, Auckland, New Zealand
Prucalopride Prior to Small Bowel Capsule Endoscopy
- First Posted Date
- 2016-06-20
- Last Posted Date
- 2016-07-15
- Lead Sponsor
- University of British Columbia
- Target Recruit Count
- 122
- Registration Number
- NCT02806206
- Locations
- 🇨🇦
Vancouver General Hospital, Vancouver, British Columbia, Canada
Prucalopride Versus Placebo in Gastroparesis
- First Posted Date
- 2015-07-29
- Last Posted Date
- 2024-07-10
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Target Recruit Count
- 60
- Registration Number
- NCT02510976
- Locations
- 🇧🇪
University Hospitals, Leuven, Vlaanderen, Belgium
Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway
- Conditions
- Interventions
- First Posted Date
- 2015-04-24
- Last Posted Date
- 2023-02-08
- Lead Sponsor
- KU Leuven
- Target Recruit Count
- 30
- Registration Number
- NCT02425774
- Locations
- 🇧🇪
University hospitals Leuven, Leuven, Vlaams-Brabant, Belgium
Efficacy and Safety of Prucalopride in Combination With Polyethylene Glycol or Lactulose in Women With Chronic Constipation
- Conditions
- Interventions
- First Posted Date
- 2014-08-29
- Last Posted Date
- 2017-09-15
- Lead Sponsor
- Xian-Janssen Pharmaceutical Ltd.
- Target Recruit Count
- 280
- Registration Number
- NCT02228616
Effect Comparison of Electro-acupuncture and Prucalopride for Severe Chronic Constipation: a Randomized Controlled Trial
- First Posted Date
- 2014-01-28
- Last Posted Date
- 2021-03-22
- Target Recruit Count
- 560
- Registration Number
- NCT02047045
Drug Development Updates
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