Prucalopride
- Generic Name
- Prucalopride
- Brand Names
- Motegrity, Resolor, Resotran
- Drug Type
- Small Molecule
- Chemical Formula
- C18H26ClN3O3
- CAS Number
- 179474-81-8
- Unique Ingredient Identifier
- 0A09IUW5TP
- Background
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride...
- Indication
Prucalopride is indicated for the treatment of chronic idiopathic constipation (CIC) in adults.
CIC is one of the most common chronic functional gastrointestinal disorders worldwide. The diagnosis of this agent is very hard and it can be confirmed if the patient experience at least two of the following:
...
- Associated Conditions
- Opioid Induced Constipation (OIC), Chronic idiopathic constipation (CIC), Refractory Chronic idiopathic constipation
- Associated Therapies
- -
Study to Evaluate Long-Term Safety, Tolerability, and Satisfaction With Prucalopride in Chronic Constipation
- Conditions
- First Posted Date
- 2009-10-01
- Last Posted Date
- 2009-10-01
- Lead Sponsor
- Movetis
- Target Recruit Count
- 1775
- Registration Number
- NCT00987844
- Locations
- 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States
Thorough Corrected QT Interval (QTc) Study To Evaluate Possible Effects of Prucalopride on ECG Parameters
- Conditions
- Interventions
- First Posted Date
- 2009-05-18
- Last Posted Date
- 2009-05-18
- Lead Sponsor
- Movetis
- Target Recruit Count
- 120
- Registration Number
- NCT00903747
Safety Study of Prucalopride in Healthy Volunteers
- Conditions
- First Posted Date
- 2008-11-19
- Last Posted Date
- 2008-11-21
- Lead Sponsor
- Movetis
- Registration Number
- NCT00793429
Efficacy and Safety Study of Prucalopride for the Treatment of Chronic Constipation
- First Posted Date
- 2008-03-10
- Last Posted Date
- 2008-05-29
- Lead Sponsor
- Movetis
- Target Recruit Count
- 253
- Registration Number
- NCT00631813
Evaluation of the Safety and Tolerability of Prucalopride in Constipated Elderly Subjects Living in a Nursing Facility
- First Posted Date
- 2008-03-03
- Last Posted Date
- 2008-05-29
- Lead Sponsor
- Movetis
- Target Recruit Count
- 100
- Registration Number
- NCT00627692
Efficacy and Safety Study of Prucalopride for the Treatment of Chronic Constipation
- First Posted Date
- 2008-02-18
- Last Posted Date
- 2008-05-29
- Lead Sponsor
- Movetis
- Target Recruit Count
- 174
- Registration Number
- NCT00617513
Efficacy and Safety Study of Prucalopride for the Re-Treatment of Chronic Constipation
- First Posted Date
- 2008-01-21
- Last Posted Date
- 2008-05-29
- Lead Sponsor
- Movetis
- Target Recruit Count
- 516
- Registration Number
- NCT00598338
Trial to Evaluate the Efficacy and Safety of R093877 in Patients With Chronic Idiopathic Constipation
- Conditions
- Interventions
- First Posted Date
- 2008-01-17
- Last Posted Date
- 2008-05-29
- Lead Sponsor
- Movetis
- Target Recruit Count
- 313
- Registration Number
- NCT00596596
Efficacy and Safety Study of the Effect of Dose-Titration of Prucalopride for The Treatment of Chronic Constipation
- First Posted Date
- 2007-12-19
- Last Posted Date
- 2008-05-29
- Lead Sponsor
- Movetis
- Target Recruit Count
- 755
- Registration Number
- NCT00577018
Effect of Prucalopride in Patients With Severe Chronic Idiopathic Constipation
- First Posted Date
- 2007-12-19
- Last Posted Date
- 2008-05-29
- Lead Sponsor
- Movetis
- Target Recruit Count
- 53
- Registration Number
- NCT00576511
Drug Development Updates
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