Acetazolamide

Generic Name: Acetazolamide

Drug Type: Small Molecule

Chemical Formula: C_₄H_₆N_₄O_₃S_₂

CAS Number: 59-66-5

Unique Ingredient Identifier: O3FX965V0I

Background: One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Indication: For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma

Associated Conditions: Acute angle-closure glaucoma, Edema, Familial periodic paralysis, Generalized Tonic-Clonic Seizures, Metabolic Alkalosis, Open Angle Glaucoma (OAG), Other and unspecified effects of high altitude, Cystine renal calculi, Drug-induced edema, Nonuveitic secondary glaucoma, Salicylate intoxication

Associated Therapies: Urine alkalinization therapy

Clinical Trials

Effect of Acetazolamide on Postural Control in Lowlanders Older Than 40 Years at Altitude

Phase 4

Completed

Conditions: Altitude Hypoxia

Interventions: Drug: ACETAZOLAMIDE oral capsule
Drug: Placebo oral capsule

First Posted Date: 2018-05-24

Last Posted Date: 2021-10-12

Lead Sponsor: University of Zurich

Target Recruit Count: 99

Registration Number: NCT03536429

Locations: 🇰🇬
National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan

Effect of Acetazolamide on Maximal Exercise Performance in Lowlanders Older Than 40 Years at Altitude

Phase 4

Completed

Conditions: Altitude Hypoxia

Interventions: Drug: ACETAZOLAMIDE oral capsule
Drug: Placebo oral capsule

First Posted Date: 2018-05-24

Last Posted Date: 2021-10-12

Lead Sponsor: University of Zurich

Target Recruit Count: 92

Registration Number: NCT03536455

Locations: 🇰🇬
National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan

Acetazolamide and Exercise Performance at Altitude

Early Phase 1

Completed

Conditions: Hypoxia
Dexterity
Exercise Performance
Cognitive Function

Interventions: Drug: Placebo pill
Drug: Acetazolamide Pill

First Posted Date: 2018-05-15

Last Posted Date: 2019-07-05

Lead Sponsor: United States Army Research Institute of Environmental Medicine

Target Recruit Count: 10

Registration Number: NCT03525561

Locations: 🇺🇸
Natick Soldier Systems Center, Natick, Massachusetts, United States

Acetazolamide in Decompensated Heart Failure With Volume OveRload (ADVOR)

Phase 4

Completed

Conditions: Acute Decompensated Heart Failure
Volume Overload

Interventions: Drug: Placebo
Drug: Acetazolamide

First Posted Date: 2018-04-23

Last Posted Date: 2024-10-28

Lead Sponsor: Ziekenhuis Oost-Limburg

Target Recruit Count: 519

Registration Number: NCT03505788

Locations: 🇧🇪
Ziekenhuis Oost-Limburg AV, Genk, Limburg, Belgium

Surgical Idiopathic Intracranial Hypertension Treatment Trial

Phase 3

Terminated

Conditions: Idiopathic Intracranial Hypertension

Interventions: Procedure: Ventriculoperitoneal CSF Shunting
Procedure: Optic Nerve Sheath Fenestration
Drug: Acetazolamide

First Posted Date: 2018-04-18

Last Posted Date: 2022-06-16

Lead Sponsor: Jaeb Center for Health Research

Target Recruit Count: 7

Registration Number: NCT03501966

Locations: 🇺🇸
New York Eye & Ear Infirmary of Mount Sinai, New York, New York, United States
🇺🇸
Stanford University, Palo Alto, California, United States
🇺🇸
State University of New York at Stony Brook, East Setauket, New York, United States

and more 33 locations