Ipilimumab
- Generic Name
- Ipilimumab
- Brand Names
- Yervoy
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 477202-00-9
- Unique Ingredient Identifier
- 6T8C155666
- Background
Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes. Ipilimumab was developed by Bristol-Myers Squibb and Medarex.
Ipilimumab was granted FDA approval on 25 March 2011.
- Indication
Ipilimumab is indicated in the following cancerous conditions:
Melanoma
Renal Cell Carcinoma (RCC)
Colorectal Cancer
Hepatocellular Carcinoma
Non-Small Cell Lung Cancer (NSCLC)
Malignant Pleural Mesothelioma
Esophageal Cancer
- Treatment of adult patients with unresectable advanced or metastatic esophageal squamous cell carcinoma, as first line treatment in combination with nivolumab
- Associated Conditions
- Cutaneous Melanoma, Hepatocellular Carcinoma, Metastatic Esophageal Squamous Cell Carcinoma, Metastatic Melanoma, Metastatic Non-Small Cell Lung Cancer, Microsatellite Instability High Metastatic Colorectal Cancer (CRC), Mismatch Repair-deficient (dMMR) Metastatic Colorectal Cancer (CRC), Recurrent Non-small Cell Lung Cancer, Unresectable Melanoma, Poor or intermediate risk Advanced Renal Cell Carcinoma (aRCC), Unresectable Malignant Pleural Mesothelioma (MPM), Unresectable, advanced Esophageal Squamous Cell Carcinoma (ESCC)
- Associated Therapies
- First Line Chemotherapy
Adoptive Cell Therapy Following a Non-myeloablative, Lymphodepleting Induction Regimen in Metastatic Melanoma Patients
- Conditions
- Interventions
- First Posted Date
- 2017-05-25
- Last Posted Date
- 2023-01-26
- Lead Sponsor
- Sheba Medical Center
- Target Recruit Count
- 30
- Registration Number
- NCT03166397
- Locations
- 🇮🇱
Sheba Medical Center, Ramat Gan, Israel
Evaluation of Denosumab in Combination With Immune Checkpoint Inhibitors in Patients With Unresectable or Metastatic Melanoma
- Conditions
- Interventions
- First Posted Date
- 2017-05-22
- Last Posted Date
- 2022-04-07
- Lead Sponsor
- Melanoma and Skin Cancer Trials Limited
- Target Recruit Count
- 72
- Registration Number
- NCT03161756
- Locations
- 🇦🇺
Royal Hobart Hospital, Hobart, Tasmania, Australia
🇦🇺Box Hill Hospital, Box Hill, Victoria, Australia
🇦🇺Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
A Study of Combination with TBI-1401(HF10) and Ipilimumab in Japanese Patients with Unresectable or Metastatic Melanoma
- Conditions
- Interventions
- First Posted Date
- 2017-05-15
- Last Posted Date
- 2024-12-09
- Lead Sponsor
- Takara Bio Inc.
- Target Recruit Count
- 28
- Registration Number
- NCT03153085
- Locations
- 🇯🇵
Clinical Site, Ōsaka, Japan
Investigator-Initiated Trial of Combined Ipilimumab, Nivolumab and Stereotactic Radiation in Patients With Metastatic Clear-Cell RCC (ccRCC) Who Have Failed Treatment With Single-Agent Nivolumab
- Conditions
- Interventions
- First Posted Date
- 2017-05-11
- Last Posted Date
- 2018-06-18
- Lead Sponsor
- Medical University of South Carolina
- Registration Number
- NCT03149159
- Locations
- 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States
SAINT:Trabectedin, Ipilimumab and Nivolumab as First Line Treatment for Advanced Soft Tissue Sarcoma
- Conditions
- Interventions
- First Posted Date
- 2017-05-03
- Last Posted Date
- 2024-04-18
- Lead Sponsor
- Sarcoma Oncology Research Center, LLC
- Target Recruit Count
- 45
- Registration Number
- NCT03138161
- Locations
- 🇺🇸
Sarcoma Oncology Research Center, Santa Monica, California, United States
A Study Comparing Nivolumab, Nivolumab in Combination With Ipilimumab and Placebo in Participants With Localized Kidney Cancer Who Underwent Surgery to Remove Part of a Kidney
- Conditions
- Interventions
- First Posted Date
- 2017-05-03
- Last Posted Date
- 2024-12-18
- Lead Sponsor
- Bristol-Myers Squibb
- Target Recruit Count
- 1641
- Registration Number
- NCT03138512
- Locations
- 🇺🇸
Local Institution - 0019, Birmingham, Alabama, United States
🇺🇸Local Institution - 0056, Springdale, Arkansas, United States
🇺🇸Local Institution - 0186, Los Angeles, California, United States
Intermittent Therapy in Metastatic Renal Cell Carcinoma Patients Treated With Ipilimumab and Nivolumab
- Conditions
- Interventions
- First Posted Date
- 2017-04-24
- Last Posted Date
- 2024-03-18
- Lead Sponsor
- Case Comprehensive Cancer Center
- Target Recruit Count
- 26
- Registration Number
- NCT03126331
- Locations
- 🇺🇸
Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
SAbR Plus Ipilimumab Plus Nivolumab in Metastatic Melanoma Patients
- Conditions
- Interventions
- First Posted Date
- 2017-04-24
- Last Posted Date
- 2020-08-20
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Registration Number
- NCT03126461
- Locations
- 🇺🇸
University of Texas Southwestern Medical Center - Dallas, Dallas, Texas, United States
Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 Combined With Immune Therapies in Advanced or Metastatic Malignancies
- Conditions
- Interventions
- First Posted Date
- 2017-04-24
- Last Posted Date
- 2022-12-28
- Lead Sponsor
- Incyte Biosciences International Sàrl
- Target Recruit Count
- 145
- Registration Number
- NCT03126110
- Locations
- 🇺🇸
The Angeles Clinic and Research Institute, Los Angeles, California, United States
🇺🇸Karmanos Cancer Institute, Detroit, Michigan, United States
🇺🇸Washington University - Siteman Cancer Center, Saint Louis, Missouri, United States
A Study to Evaluate Adaptive Dosing of Ipilimumab and Nivolumab Combination Immunotherapy
- Conditions
- Interventions
- First Posted Date
- 2017-04-20
- Last Posted Date
- 2024-05-02
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Target Recruit Count
- 70
- Registration Number
- NCT03122522
- Locations
- 🇺🇸
JOHNS HOPKINS HOSPITAL (Data Analysis Only), Baltimore, Maryland, United States
🇺🇸Columbia University (Data Analysis Only), New York, New York, United States
🇺🇸Brigham and Women's Hospital (Data and Specimen Analysis Only), Boston, Massachusetts, United States
Drug Development Updates
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