Vincristine

Generic Name
Vincristine
Brand Names
Marqibo, Vincasar
Drug Type
Small Molecule
Chemical Formula
C46H56N4O10
CAS Number
57-22-7
Unique Ingredient Identifier
5J49Q6B70F
Background

Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristin...

Indication

Treatment of acute lymphocytic leukemia (ALL), Hodgkin lymphoma, non-Hodgkin lymphomas, Wilms' tumor, neuroblastoma, rhabdomyosarcoma. Liposomal vincristine is indicated for the treatment of relapsed Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).

Associated Conditions
Acute Lymphoblastic Leukemia (ALL), Choriocarcinoma, Chronic Lymphocytic Leukemia, Ewing's Sarcoma, Gestational Trophoblastic Neoplasia, Hepatoblastomas, Hodgkin's Lymphoma, Immune Thrombocytopenia (ITP), Kaposi's Sarcoma, Multiple Myeloma (MM), Neuroblastoma (NB), Non-Hodgkin's Lymphoma (NHL), Ovarian germ cell tumour, Pheochromocytoma, Relapsed Acute Lymphoblastic Leukemia (ALL), Retinoblastoma, Rhabdomyosarcomas, Small Cell Lung Cancer (SCLC), Wilms' tumor, Advanced Thymoma
Associated Therapies
-

Study of Safety and Efficacy of Pembrolizumab and Chemotherapy in Participants With Newly Diagnosed Classical Hodgkin Lymphoma (cHL) (MK-3475-C11/KEYNOTE-C11)

First Posted Date
2021-08-17
Last Posted Date
2024-11-20
Lead Sponsor
Merck Sharp & Dohme LLC
Target Recruit Count
146
Registration Number
NCT05008224
Locations
🇺🇸

Stanford Cancer Center ( Site 0023), Palo Alto, California, United States

🇺🇸

Northwestern Memorial Hospital ( Site 0002), Chicago, Illinois, United States

🇺🇸

Texas Oncology-Plano East ( Site 0020), Plano, Texas, United States

and more 45 locations

A Study to Evaluate the Safety and Efficacy of Glofitamab in Combination With Rituximab (R) Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Circulating Tumor (ct)DNA High-Risk Patients With Untreated Diffuse Large B-Cell Lymphoma

First Posted Date
2021-07-28
Last Posted Date
2024-12-02
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
46
Registration Number
NCT04980222
Locations
🇪🇸

Hospital Clinico Universitario de Salamanca;Servicio de Hematologia, Salamanca, Spain

🇺🇸

City of Hope Comprehensive Cancer Center, Duarte, California, United States

🇺🇸

Stanford Cancer Center, Palo Alto, California, United States

and more 24 locations

A Study of N9 Chemotherapy in Children With Neuroblastoma

First Posted Date
2021-07-01
Last Posted Date
2024-12-02
Lead Sponsor
Memorial Sloan Kettering Cancer Center
Target Recruit Count
26
Registration Number
NCT04947501
Locations
🇺🇸

Memorial Sloan Kettering Cancer Center, New York, New York, United States

Efficacy and Safety of Lenalidomide Plus CHOP vs CHOP in Patients With Untreated Peripheral T-Cell Lymphoma

First Posted Date
2021-06-10
Last Posted Date
2022-11-07
Lead Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
Target Recruit Count
289
Registration Number
NCT04922567
Locations
🇨🇳

2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

A Multicentre, Parallel Arm, Open-label Trial of Frontline R-CHOP/Pola-RCHP and Glofitamab in Younger, Higher Risk Patients With Diffuse Large B Cell Lymphoma (DLBCL)

First Posted Date
2021-06-07
Last Posted Date
2024-08-12
Lead Sponsor
Peter MacCallum Cancer Centre, Australia
Target Recruit Count
80
Registration Number
NCT04914741
Locations
🇦🇺

Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

🇦🇺

St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia

🇦🇺

Alfred Hospital, Melbourne, Victoria, Australia

and more 12 locations

Vincristine and Temozolomide in Combination With PEN-866 for Adolescents and Young Adults With Relapsed or Refractory Solid Tumors

First Posted Date
2021-05-18
Last Posted Date
2024-12-06
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
64
Registration Number
NCT04890093
Locations
🇺🇸

Childrens National Medical Center, Washington, District of Columbia, United States

🇺🇸

National Institutes of Health Clinical Center, Bethesda, Maryland, United States

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