Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Rhomboid Intercostal Sub Serratus Plane Block Versus Serratus Anterior Plane Block in Thoractomy

Not Applicable

Recruiting

Conditions: Thoracic
Pain

Interventions: Drug: Bupivacain
Device: Ultrasound

First Posted Date: 2025-03-04

Last Posted Date: 2025-03-06

Lead Sponsor: Yasser S Mostafa, MD

Target Recruit Count: 40

Registration Number: NCT06856538

Locations: 🇪🇬
Fayoum University hospital, Madīnat al Fayyūm, Faiyum Governorate, Egypt

Comparison of Analgesic Efficacy of Quadratus Lumborum Type 3 and Suprainguinal Fascia Iliaca Compartment Block in Total Hip Arthroplasty Surgery

Not Applicable

Completed

Conditions: Opioid Consumption
Pain Postoperative

Interventions: Drug: Bupivacain

First Posted Date: 2025-02-20

Last Posted Date: 2025-02-20

Lead Sponsor: Başakşehir Çam & Sakura City Hospital

Target Recruit Count: 60

Registration Number: NCT06838156

Locations: 🇹🇷
Başakşehir Çam Ve Sakura City Hospital, Başakşehi̇r, İ̇stanbul, Turkey

A Comparative Study of Erector Spinae Plane Block and Serratus Posterior Superior Intercostal Plane Block on Postoperative Opioid Consumption Following Breast and Axillary Dissection Surgery

Not Applicable

Recruiting

Conditions: Breast Surgery
Erector Spinae Plane Block
Serratus Posterior Superior Intercostal Plane Block

Interventions: Procedure: erector spinae plane block
Procedure: serratus posterior superior intercostal plane block
Drug: 0.25% bupivacaine

First Posted Date: 2025-02-19

Last Posted Date: 2025-04-20

Lead Sponsor: Medipol University

Target Recruit Count: 60

Registration Number: NCT06833697

Locations: 🇹🇷
Medipol University, Istanbul, Turkey

Dexmedetomidine as an Adjuvant to Bupivacaine in Ultrasound-Guided Quadratus Lumborum Block for Postoperative Analgesia in Laparoscopic Cholecystectomy

Not Applicable

Completed

Conditions: Dexmedetomidine
Bupivacaine
Ultrasound-Guided
Quadratus Lumborum Block
Postoperative Analgesia
Laparoscopic Cholecystectomy

Interventions: Drug: Bupivacaine
Drug: Bupivacaine and Dexmedetomidinc) group

First Posted Date: 2025-02-13

Last Posted Date: 2025-02-13

Lead Sponsor: Tanta University

Target Recruit Count: 90

Registration Number: NCT06825286

Locations: 🇪🇬
Tanta University, Tanta, ElGharbia, Egypt

Adding Magnesium Sulfate to Local Anesthetic in Combined Pectoral Nerve and Stellate Ganglion Block for Postoperative Pain Control After Modified Radical Mastectomy

Not Applicable

Recruiting

Conditions: Local Anesthetic
Pectoral Nerve
Postoperative Pain
Modified Radical Mastectomy
Magnesium Sulfate
Stellate Ganglion Block

Interventions: Drug: Bupivacaine + Magnesium sulfate
Drug: Bupivacaine

First Posted Date: 2025-02-10

Last Posted Date: 2025-02-10

Lead Sponsor: Cairo University

Target Recruit Count: 70

Registration Number: NCT06815887

Locations: 🇪🇬
Cairo University, Cairo, Egypt

The Efficacy of Liposomal Bupivacaine in Ultrasound Guided Supraclavicular Nerve Blocks for Hand and Wrist Surgery

Phase 4

Active, not recruiting

Conditions: Hand Surgery
Wrist Surgery
Elbow Surgery
Fracture Fixation
Dupuytren Contracture
Finger Fracture
Wrist Arthropathy
Distal Radius Fracture

Interventions: Drug: Dexamethasone
Drug: Liposomal bupivacaine (LB)

First Posted Date: 2025-02-04

Last Posted Date: 2025-02-06

Lead Sponsor: St. Luke's Hospital, Pennsylvania

Target Recruit Count: 120

Registration Number: NCT06806410

Locations: 🇺🇸
St. Luke's University Health Network, Bethlehem, Pennsylvania, United States

Intraperitoneal Ketamine Versus Bupivacaine for Postoperative Pain Control After Laparoscopic Cholecystectomy

Early Phase 1

Completed

Conditions: Laparoscopic Cholecystectomy Surgery

Interventions: Drug: Ketamine
Drug: Bupivacaine

First Posted Date: 2025-02-04

Last Posted Date: 2025-02-07

Lead Sponsor: Liaquat National Hospital & Medical College

Target Recruit Count: 92

Registration Number: NCT06807554

Locations: 🇵🇰
Liaquat National Hospital, Karachi, Sindh, Pakistan

Study Assessing Pain Relief After Replacement of the Knee

Phase 2

Recruiting

Conditions: Total Knee Arthroplasty (Postoperative Pain)

Interventions: Drug: saline placebo
Drug: bupivacaine hydrochloride
Drug: ATX101

First Posted Date: 2025-01-29

Last Posted Date: 2025-05-07

Lead Sponsor: Allay Therapeutics, Inc.

Target Recruit Count: 200

Registration Number: NCT06799845

Locations: 🇺🇸
Clinical Pharmacology of Miami, LLC, Miami, Florida, United States
🇺🇸
Woodland International Research Group, LLC, Little Rock, Arkansas, United States
🇺🇸
Phoenix Clinical Research, Tamarac, Florida, United States

and more 9 locations