Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Combined Spinal-epidural Anesthesia for Cesarean Section Without Prophylactical Prehydration and Vasopressors
- Conditions
- Cesarean SectionAnesthesia, Spinal
- Interventions
- First Posted Date
- 2018-04-13
- Last Posted Date
- 2020-11-18
- Lead Sponsor
- Shenzhen People's Hospital
- Target Recruit Count
- 930
- Registration Number
- NCT03497364
- Locations
- 🇨🇳
ShenZhen People's Hospital of Jinan University, Shenzhen, Guangdong, China
PEC Block II in Mammoplasty Surgeries
- Conditions
- MammaplastyAnesthesia, ConductionAnalgesiaAnalgesia, Patient-Controlled
- Interventions
- Drug: Normal Saline 0,9%Drug: Bupivacaine
- First Posted Date
- 2018-04-05
- Last Posted Date
- 2018-04-05
- Lead Sponsor
- Federal University of São Paulo
- Target Recruit Count
- 40
- Registration Number
- NCT03488888
- Locations
- 🇧🇷
Federal University of Sao Paulo, São Paulo, Sao Paulo, Brazil
Study in Pediatric Subjects Evaluating Pharmacokinetics and Safety of EXPAREL
- First Posted Date
- 2018-04-02
- Last Posted Date
- 2023-08-02
- Lead Sponsor
- Pacira Pharmaceuticals, Inc
- Target Recruit Count
- 15
- Registration Number
- NCT03485014
- Locations
- 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States
Long Thoracic Nerve Blockade for Pain Treatment After Video-Assisted Thoracoscopic Surgery
- Conditions
- Video-Assisted Thoracic SurgeryNerve Block
- Interventions
- First Posted Date
- 2018-03-30
- Last Posted Date
- 2018-03-30
- Lead Sponsor
- Bursa Yüksek İhtisas Education and Research Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT03483415
Wound Infiltration With Local Anesthetic Agent for Laparoscopic Appendectomy in Adult
- First Posted Date
- 2018-03-29
- Last Posted Date
- 2020-04-27
- Lead Sponsor
- National Taiwan University Hospital
- Target Recruit Count
- 47
- Registration Number
- NCT03481517
- Locations
- 🇨🇳
National Taiwan University Hospital, Taipei, Taiwan
Effect of Addition of Fentanyl or Dexamethasone or Both to Bupivacaine in Paravertebral Block for Patients Undergoing Major Breast Surgery
- Conditions
- Paravertebral Block
- Interventions
- First Posted Date
- 2018-03-29
- Last Posted Date
- 2021-02-23
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 1
- Registration Number
- NCT03480308
- Locations
- 🇪🇬
Amonios Khalil gerges, Assiut, Egypt
Evaluation of the Analgesic Effect of Dexmedetomidine Versus Fentanyl as Adjuvants to Epidural Bupivacaine in Patients Undergoing Lumbar Spine Surgeries
- Conditions
- Dexmedetomidine VS Fentanyl as Adjuvants to Epidural Bupivacaine in Patients Undergoing Lumbar Spine Surgeries
- Interventions
- First Posted Date
- 2018-03-13
- Last Posted Date
- 2018-05-30
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 60
- Registration Number
- NCT03463083
- Locations
- 🇪🇬
Ahmed Abdalla Mohamed, Cairo, Egypt
Caudal Dexmetedomedine Versus Magnesium in Orthopedic Pediatric Surgeries
- Conditions
- Pain in Pediatric Patients
- Interventions
- First Posted Date
- 2018-03-09
- Last Posted Date
- 2018-03-09
- Lead Sponsor
- Hagar hassanein refaee
- Target Recruit Count
- 36
- Registration Number
- NCT03460041
- Locations
- 🇪🇬
Cairo University faculty, Cairo, Egypt
Dexmedetomidine Versus Fentanyl Plus Bupivacaine for Epidural Analgesia With General Anesthesia for Lumbar Disc Operations
- Conditions
- Anesthesia
- Interventions
- First Posted Date
- 2018-02-19
- Last Posted Date
- 2018-09-27
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 80
- Registration Number
- NCT03438240
- Locations
- 🇪🇬
Ain Shams University hospitals, Cairo, Egypt
Study in Adult Subjects Undergoing Posterolateral Thoracotomy
- First Posted Date
- 2018-02-12
- Last Posted Date
- 2019-02-06
- Lead Sponsor
- Pacira Pharmaceuticals, Inc
- Target Recruit Count
- 5
- Registration Number
- NCT03428984
- Locations
- 🇺🇸
MD Anderson Cancer Center, Houston, Texas, United States
Drug Development Updates
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