Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Effect of Intrathecal Morphine, Dexmedetomidine or Both in Combination to Bupivacaine on Immunity

Phase 1

Conditions: Immune System Suppression

Interventions: Drug: Dexmedetomidine
Drug: Morphine Sulfate
Drug: Bupivacaine

First Posted Date: 2017-01-19

Last Posted Date: 2021-01-14

Lead Sponsor: Assiut University

Target Recruit Count: 30

Registration Number: NCT03024957

Locations: 🇪🇬
Assiut University, Assiut, Egypt

Pectoralis and Serratus Nerves Block in Thoracic Surgery

Phase 2

Conditions: Surgery
Anesthesia
Block
Thoracic Injury

Interventions: Drug: Bupivacaine Hydrochloride
Device: Ultrasound
Procedure: Thoracotomy
Drug: Opioids
Drug: NSAID

First Posted Date: 2017-01-18

Last Posted Date: 2017-01-18

Lead Sponsor: Soroka University Medical Center

Target Recruit Count: 168

Registration Number: NCT03023982

Does Liposomal Bupivacaine Provide Improved Pain Management for ORIF of Midshaft Clavicle Fractures?

Phase 4

Withdrawn

Conditions: Clavicle Fracture

Interventions: Drug: Liposomal Bupivacaine
Drug: Bupivacaine

First Posted Date: 2017-01-13

Last Posted Date: 2018-10-16

Lead Sponsor: University of Minnesota

Registration Number: NCT03020563

Locations: 🇺🇸
University of Minnesota, Minneapolis, Minnesota, United States

Phenylephrine and Noradrenaline for Post Spinal Anesthesia Hypotension

Phase 2

Completed

Conditions: Adverse Anesthesia Outcome

Interventions: Drug: phenylephrine
Drug: Norepinephrine
Drug: Bupivacaine
Drug: Fentanyl
Drug: Placebo (normal saline)

First Posted Date: 2017-01-10

Last Posted Date: 2017-05-03

Lead Sponsor: Kasr El Aini Hospital

Target Recruit Count: 200

Registration Number: NCT03015857

Phase 4, Controlled Study in Adult Subjects Undergoing Primary, 1-2 Level, Open Lumbar Spinal Fusion Surgery

Phase 4

Terminated

Conditions: Postoperative Pain Management

Interventions: Drug: Bupivacaine HCl
Drug: EXPAREL and bupivacaine HCl

First Posted Date: 2017-01-10

Last Posted Date: 2021-10-13

Lead Sponsor: Pacira Pharmaceuticals, Inc

Target Recruit Count: 38

Registration Number: NCT03015961

Locations: 🇺🇸
Beaumont Health, Troy, Michigan, United States
🇺🇸
Washington Univ, Saint Louis, Missouri, United States
🇺🇸
Icahn School of Medicine, New York, New York, United States

and more 12 locations