Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Impact of Analgesia on Success of External Version: Comparison of Spinal Anesthesia Versus Sedation

Phase 3

Conditions: Breech Presentation

Interventions: Drug: Midazolam
Drug: Bupivacaine

First Posted Date: 2016-06-15

Last Posted Date: 2018-08-08

Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Target Recruit Count: 200

Registration Number: NCT02801201

Locations: 🇫🇷
CHU Amiens, Amiens, France

Effect of Dexmedetomidine and Bupivacaine for Paravertebral Block

Not Applicable

Completed

Conditions: Fracture of Proximal Femur

Interventions: Drug: Mixture of bupivacaine and dexmedetomidine
Drug: Bupivacaine

First Posted Date: 2016-06-15

Last Posted Date: 2020-09-22

Lead Sponsor: Mansoura University

Target Recruit Count: 88

Registration Number: NCT02801188

Locations: 🇪🇬
Mansoura university, Mansoura, DK, Egypt

Single Injection Adductor Canal Block vs Catheter for Total Knee Arthroplasty

Phase 4

Completed

Conditions: Total Knee Arthroplasty

Interventions: Drug: Adductor canal block
Drug: Adductor canal catheter
Drug: Adductor canal block with dexamethasone
Drug: Bupivacaine
Drug: Fentanyl
Drug: Ropivacaine 0.5% Injectable Solution
Drug: Dexamethasone

First Posted Date: 2016-06-14

Last Posted Date: 2020-09-04

Lead Sponsor: University of British Columbia

Target Recruit Count: 180

Registration Number: NCT02798835

Comparison of Surgical Rectus Sheath Block and Intrathecal Morphine

Phase 4

Completed

Conditions: Pain

Interventions: Drug: Bupivacaine
Drug: Morphine

First Posted Date: 2016-06-03

Last Posted Date: 2016-10-04

Lead Sponsor: Queen Mary Hospital, Hong Kong

Target Recruit Count: 144

Registration Number: NCT02790099

Locations: 🇭🇰
Department of Obstetrics and Gynaecology, Queen Mary Hospital, Hong Kong, Hong Kong

TAPB vs QLBII for Kidney Transplantation Procedure

Phase 4

Completed

Conditions: Postoperative Pain

Interventions: Procedure: Quadratus Lumborum Block type II
Procedure: Transversus Abdominalis Plane Block
Drug: Bupivacaine
Device: Ultraplex

First Posted Date: 2016-05-26

Last Posted Date: 2018-05-22

Lead Sponsor: Medical University of Warsaw

Target Recruit Count: 104

Registration Number: NCT02783586

Locations: 🇵🇱
I Department of Anaesthesiology and Intensive Care, Medical University of Warsaw, Warsaw, Poland

Adductor Canal Block Versus Periarticular Bupivicaine Injection in Total Knee Arthroplasty

Phase 4

Completed

Conditions: Osteoarthritis

Interventions: Drug: Bupivacaine

First Posted Date: 2016-05-19

Last Posted Date: 2019-03-20

Lead Sponsor: Columbia University

Target Recruit Count: 155

Registration Number: NCT02777749

Locations: 🇺🇸
Columbia University Medical Center, New York, New York, United States

Stellate Ganglion Block Using Ultrasound Guidance For Treatment Of Post Clipping Cerebral Vasospasm

Phase 1

Completed

Conditions: Cerebral Vasospasm

Interventions: Procedure: Stellate Ganglion Block
Drug: Bupivacaine
Procedure: Transcranial Doppler
Procedure: Digital Subtraction Angiography

First Posted Date: 2016-05-17

Last Posted Date: 2016-05-17

Lead Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Target Recruit Count: 20

Registration Number: NCT02775318

Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy

Phase 2

Completed

Conditions: Postoperative Pain
Bunions

Interventions: Drug: HTX-002
Biological: Saline Placebo
Drug: HTX-011A
Drug: HTX-011B
Drug: Bupivacaine HCl
Drug: HTX-009

First Posted Date: 2016-05-05

Last Posted Date: 2023-10-04

Lead Sponsor: Heron Therapeutics

Target Recruit Count: 430

Registration Number: NCT02762929

The Comparison of Low Thoracic Paravertebral Block Versus Peritubal Infiltration

Phase 4

Completed

Conditions: Percutaneous Nephrolithotomy

Interventions: Drug: Bupivacaine
Device: Ultrasound

First Posted Date: 2016-05-05

Last Posted Date: 2016-10-11

Lead Sponsor: Ataturk University

Target Recruit Count: 60

Registration Number: NCT02764008

Locations: 🇹🇷
Ataturk University, Yakutiye, Erzurum, Turkey

Programmed Intermittent Epidural Bolus for Labor Analgesia During First Stage of Labor 2

Not Applicable

Completed

Conditions: Labor Pain

Interventions: Drug: Bupivacaine
Drug: Fentanyl
Device: Infusion pump

First Posted Date: 2016-05-02

Last Posted Date: 2017-05-24

Lead Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Target Recruit Count: 40

Registration Number: NCT02758405

Locations: 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada

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