Bupivacaine

Generic Name
Bupivacaine
Brand Names
Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
Drug Type
Small Molecule
Chemical Formula
C18H28N2O
CAS Number
38396-39-3
Unique Ingredient Identifier
Y8335394RO
Background

Bupivacaine is a widely used local anesthetic agent.

Indication

As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions
Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
Associated Therapies
General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Subarachnoid or Infiltration for Hemorrhoidectomy

First Posted Date
2013-08-23
Last Posted Date
2016-02-03
Lead Sponsor
Federal University of São Paulo
Target Recruit Count
40
Registration Number
NCT01927874
Locations
🇧🇷

Universidade Federal de São Paulo, São Paulo, Brazil

EXPAREL Administered Into the TAP for Analgesia in Subjects Undergoing Open Total Abdominal Hysterectomy

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2013-08-09
Last Posted Date
2021-03-02
Lead Sponsor
Pacira Pharmaceuticals, Inc
Target Recruit Count
1
Registration Number
NCT01919606

EXPAREL Administered by Infiltration Into the TAP for Prolonged Postsurgical Analgesia in Lower Abdominal Surgeries

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2013-08-08
Last Posted Date
2021-07-02
Lead Sponsor
Pacira Pharmaceuticals, Inc
Target Recruit Count
67
Registration Number
NCT01919190
Locations
🇺🇸

University of Louisville, Louisville, Kentucky, United States

🇺🇸

University of Minnesota, Minneapolis, Minnesota, United States

🇺🇸

Duke University, Durham, North Carolina, United States

and more 10 locations

Ultrasound Guided Local Infiltration Analgesia for Hip Arthroscopy

Not Applicable
Terminated
Conditions
Interventions
First Posted Date
2013-07-24
Last Posted Date
2022-08-16
Lead Sponsor
Trinity Health Of New England
Target Recruit Count
23
Registration Number
NCT01907191
Locations
🇺🇸

Saint Francis Hospital and Medical Center, Hartford, Connecticut, United States

Added Value of Local Clonidine for Spine Postoperative Pain Control, in Addition to Bupivacaine

Phase 4
Completed
Conditions
Interventions
First Posted Date
2013-07-18
Last Posted Date
2015-12-08
Lead Sponsor
St Joseph University, Beirut, Lebanon
Target Recruit Count
225
Registration Number
NCT01902108
Locations
🇱🇧

Hotel Dieu de france Hospital, Beirut, Lebanon

Discharge Conditions of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl

First Posted Date
2013-06-19
Last Posted Date
2014-06-03
Lead Sponsor
Diskapi Teaching and Research Hospital
Target Recruit Count
50
Registration Number
NCT01880775
Locations
🇹🇷

Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey

A Study of Epidural Bupivacain-soaked Absorbable Gelatin Sponge on Post-operative Pain in Lumbar Laminectomy

Not Applicable
Withdrawn
Conditions
Interventions
First Posted Date
2013-05-06
Last Posted Date
2018-01-09
Lead Sponsor
The Cleveland Clinic
Registration Number
NCT01847339
Locations
🇺🇸

Cleveland Clinic, Cleveland, Ohio, United States

Effects of Addition of Magnesium Sulfate in Spinal Anesthesia on Sensory-Motor Blocks and Postoperative Pain in Lumbar Disk Herniation Surgery

First Posted Date
2013-04-30
Last Posted Date
2013-07-02
Lead Sponsor
Isfahan University of Medical Sciences
Target Recruit Count
105
Registration Number
NCT01843296
Locations
🇮🇷

Alzahra, Isfahan, Iran, Islamic Republic of

Minimum Effective Concentration of Bupivacaine in Ultrasound-guided Axillary Brachial Plexus Block

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2013-04-24
Last Posted Date
2013-04-24
Lead Sponsor
Federal University of São Paulo
Target Recruit Count
46
Registration Number
NCT01838928
Locations
🇧🇷

Federal University of Sao Paulo, Sao Paulo, Brazil

Parasternal Nerve Block in Cardiac Patients

First Posted Date
2013-04-09
Last Posted Date
2018-08-01
Lead Sponsor
Peter A Knight
Target Recruit Count
79
Registration Number
NCT01826851
Locations
🇺🇸

University of Rochester Medical Center, Rochester, New York, United States

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