Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Role of Ultrasound Guide Greater Occipital Nerve Block at Second Cervical Vertebra in Migraine Headache Prophylaxis

Phase 4

Not yet recruiting

Conditions: Migraine Disorders

Interventions: Drug: Placebo
Drug: Bupivacaine

First Posted Date: 2024-05-29

Last Posted Date: 2024-05-29

Lead Sponsor: Mahidol University

Target Recruit Count: 108

Registration Number: NCT06432127

Locations: 🇹🇭
Raviwon Atisook, Bangkok, Thailand

Liposomal Bupivacaine vs Ropivacaine for TAPBs

Phase 3

Recruiting

Conditions: Ropivacaine
Postoperative Analgesia
Liposomal Bupivacaine
Abdominal Tumor

Interventions: Drug: Liposomal Bupivacaine
Drug: Ropivacaine

First Posted Date: 2024-05-28

Last Posted Date: 2024-05-28

Lead Sponsor: Sun Yat-sen University

Target Recruit Count: 74

Registration Number: NCT06430112

Locations: 🇨🇳
Jingdun Xie, Guangzhou, Guangdong, China

Comparison Between (GNB) Combined With (IPACK) Block Versus ACB in TKA

Not Applicable

Completed

Conditions: Post Operative Pain

Interventions: Procedure: Adductor canal block
Procedure: Ultrasound guided Genicular nerve block
Procedure: Interspace between the popliteal artery and the capsule of the popliteal artery and the capsule of the posterior knee
Drug: Bupivacaine Hydrochloride

First Posted Date: 2024-05-21

Last Posted Date: 2025-01-07

Lead Sponsor: Ain Shams University

Target Recruit Count: 50

Registration Number: NCT06423339

Locations: 🇪🇬
Ain shams university hospitals, Cairo, Egypt

Effect of Adding Dexamethasone to Bupivacaine 0.25% in SCPB on Surgical Field Visibility During Tympanomastoid Surgery

Phase 4

Not yet recruiting

Conditions: Surgical Field
Postoperative Pain

Interventions: Drug: dexamethasone 2 mg in bupivacaine 0.25%
Drug: bupivacaine 0.25%

First Posted Date: 2024-05-16

Last Posted Date: 2024-05-17

Lead Sponsor: Cairo University

Target Recruit Count: 56

Registration Number: NCT06416891

Locations: 🇪🇬
Faculty of Medicine, Cairo University, Cairo, Egypt

Comparison of Infraclavicular Brachial Plexus Block and Local Anesthesia in Arteriovenous Fistula Surgeries and Their Effects on Tissue Oxygen Saturation

Not Applicable

Completed

Conditions: Renal Disease, Chronic

Interventions: Device: NIRS
Drug: Prilocaine
Other: Pinprick Test
Other: Modified Bromage Scale
Drug: Bupivacaine

First Posted Date: 2024-05-16

Last Posted Date: 2025-01-10

Lead Sponsor: Ankara City Hospital Bilkent

Target Recruit Count: 60

Registration Number: NCT06416111

Locations: 🇹🇷
Ankara Bilkent City Hospital, Ankara, Çankaya, Turkey

Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy

Phase 2

Recruiting

Conditions: Pancreatic Neoplasm
Duodenal Neoplasm

Interventions: Drug: Bupivacaine
Drug: Liposomal Bupivacaine
Drug: Hydromorphone
Drug: Iopamidol
Other: Medical Chart Review
Other: Questionnaire Administration
Procedure: Ultrasound Imaging
Drug: Thoracic Epidural Analgesia
Procedure: X-Ray Imaging