Atovaquone
- Generic Name
- Atovaquone
- Brand Names
- Malarone, Mepron
- Drug Type
- Small Molecule
- Chemical Formula
- C22H19ClO3
- CAS Number
- 95233-18-4
- Unique Ingredient Identifier
- Y883P1Z2LT
- Background
Atovaquone is a hydroxynaphthoquinone, or an analog of ubiquinone, that has antimicrobial and antipneumocystis activity. It is being used in antimalarial protocols.
- Indication
主要用于治疗恶性疟原虫感染（对氯喹敏感或耐药者）；还可用于艾滋病患者合并卡氏肺囊虫病或弓形原虫性脑炎等治疗以及轻中度不能耐受复方磺胺药的肺孢子菌肺炎（PCP肺炎）。
- Associated Conditions
- Malaria caused by Plasmodium falciparum, Pneumocystis Jirovecii Pneumonia, Toxoplasma gondii encephalitis, Acute, uncomplicated Malaria caused by plasmodium falciparum, Mild Babesiosis, Mild Pneumocystis jiroveci pneumonia, Moderate Babesiosis, Moderate Pneumocystis jiroveci pneumonia
- Associated Therapies
- -
Phase I Safety and Pharmacokinetics Study of Microparticulate Atovaquone (m-Atovaquone; 566C80) in HIV-Infected and Perinatally Exposed Infants and Children
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-10-28
- Target Recruit Count
- 24
- Registration Number
- NCT00000773
- Locations
- 🇺🇸
Tulane/LSU Maternal/Child CRS, New Orleans, Louisiana, United States
🇺🇸St. Jude/UTHSC CRS, Memphis, Tennessee, United States
🇺🇸Chicago Children's CRS, Chicago, Illinois, United States
A Randomized, Double-Blind Study of 566C80 Versus Septra (Sulfamethoxazole/Trimethoprim) for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2011-03-01
- Target Recruit Count
- 300
- Registration Number
- NCT00000655
- Locations
- 🇺🇸
Georgetown Univ Med Ctr, Washington, District of Columbia, United States
🇺🇸Univ of Cincinnati, Cincinnati, Ohio, United States
🇺🇸Veterans Administration Med Ctr, Washington, District of Columbia, United States
A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 700
- Registration Number
- NCT00000802
- Locations
- 🇺🇸
Case CRS, Cleveland, Ohio, United States
🇺🇸Ucsd, Avrc Crs, San Diego, California, United States
🇺🇸Univ. of Miami AIDS CRS, Miami, Florida, United States
A Study to Compare Different Drugs Used to Prevent Serious Bacterial Infections in HIV-Positive Children
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 690
- Registration Number
- NCT00000811
- Locations
- 🇺🇸
Saint Christopher's Hosp for Children, Philadelphia, Pennsylvania, United States
🇵🇷San Juan City Hosp, San Juan, Puerto Rico
🇺🇸Texas Children's Hosp / Baylor Univ, Houston, Texas, United States
Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-10-28
- Target Recruit Count
- 100
- Registration Number
- NCT00000794
- Locations
- 🇺🇸
Northwestern University CRS, Chicago, Illinois, United States
🇺🇸Cook County Hosp. CORE Ctr., Chicago, Illinois, United States
🇺🇸Johns Hopkins Adult AIDS CRS, Baltimore, Maryland, United States
Drug Development Updates
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